MAPK

[Environmental Pollution] Using placental trophoblast cell line JEG-3, the authors demonstrated that triphenyl phosphate could induce endoplasmic reticulum stress and cell apoptosis through PPARγ-mediated lipid metabolism.

[Scientific Reports] Scientists established a novel method to generate CSCs from iPSCs under a cancerous microenvironment mimicked by the conditioned medium of cancer-derived cells.

[Scientific Reports] In a co-culture system of human umbilical vein endothelial cells and acute lymphoblastic leukemia (ALL) cells, serine protease inhibitor Kazal type 1 (SPINK1) exposure resulted in enhanced endothelial cell motility and ALL cells trans-endothelial migration.

[Clinical and Experimental Medicine] The efficacy of selumetinib in various solid tumors such as colorectal cancer, lung cancer, neurofibroma, and melanoma is investigated.

[Scientific Reports] Scientists analyzed the transcriptome of cancer stem cells, which were converted from iPSCs with conditioned medium from pancreatic ductal adenocarcinoma cells.

[Cell Death & Disease] Investigators found that inhibition of G protein-coupled receptor 4 (GPR4) with the antagonist NE52-QQ57 ameliorated osteoarthritis progression in mice, promoted ECM production, and protected cartilage from degradation in human articular cartilage explants.