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MTOR

BET Protein Inhibition Evidently Enhances Sensitivity to PI3K/mTOR Dual Inhibition in Intrahepatic Cholangiocarcinoma

[Cell Death & Disease] Investigators confirmed that BEZ235 could suppress the proliferation, invasion and colony conformation abilities of intrahepatic cholangiocarcinoma (ICC) cells in vitro but could not effectively inhibit ICC progression in vivo.

Rapamycin Targets STAT3 and Impacts C-Myc to Suppress Tumor Growth

[Cell Chemical Biology] Researchers used a chemical proteomics strategy that had identified STAT3, a transcription factor considered to be undruggable, as a direct functional protein target of rapamycin. They showed that rapamycin treatment in cell culture significantly inhibited c-Myc-regulated gene expression.

2-Deoxy-D-Glucose Impedes T Cell–Induced Apoptosis of Keratinocytes in Oral Lichen Planus

[Journal of Cellular and Molecular Medicine] Investigators explored the role of glycolysis inhibition by 2-Deoxy-D-glucose on regulating immune responses of oral lichen planus-derived T cells.

Maternal Selenium Deficiency Suppresses Proliferation, Induces Autophagy Dysfunction, Apoptosis in the Placenta of Mice

[Metallomics] Researchers found that maternal selenium (Se) deficiency decreased placental Se concentration and expressions of some antioxidant selenoproteins.

Either IL-7 Activation of JAK-STAT or BEZ Inhibition of PI3K-AKT-mTOR Pathways Dominates the Single-Cell Phosphosignature of Ex Vivo Treated Pediatric T Cell Acute Lymphoblastic...

[Haematologica] Researchers used single-cell mass cytometry to study signal transduction pathways such as the JAK-STAT, PI3K-AKT-mTOR and MEK-ERK pathways in 16 diagnostic and 5 relapsed T cell acute lymphoblastic leukemia primary samples and investigated the in vitro response of cells to interleukin-7 and the inhibitor BEZ-235.

Aronia melanocarpa Polysaccharide Ameliorates Inflammation and Aging in Mice by Modulating the AMPK/SIRT1/NF-κB Signaling Pathway and Gut Microbiota

[Scientific Reports] Scientists evaluated the delay and protection of Aronia melanocarpa polysaccharide (AMP) obtained from Aronia melanocarpa fruit on aging mice by D-Galactose induction and explored the effect of supplementing AMP on the metabolism of the intestinal flora of aging mice.

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