MTOR

[BMC Cancer] The bioactivities of inhibitors on PTEN adequate Huh7 and deficient Mahlavu cells were investigated with real time cell growth, cell cycle and cell migration assays.

[Cell Reports] Comprehensive mapping of the mTOR chromatin-bound interactome in both androgen-dependent and -independent cellular models of prostate cancer identified a conserved 67-protein interaction network enriched for chromatin modifiers, transcription factors, and SUMOylation machinery.

[Anti-Cancer Drugs] Scientists investigated whether the novel factor 3,5-dihydroxy-4-methoxybenzyl alcohol, suppressed the activity of metastatic human prostate cancer PC-3 or DU-145 cells.

[Journal of Experimental & Clinical Cancer Research] The authors provide a mechanistic discussion of autophagy in prostate cancer.

[Science Advances] Using a reverse translational approach, investigators showed a central role of NK cells in the radiation-induced immune response involving a CXCL8/IL-8–dependent mechanism.

[Haematologica] Investigators found that AML cells obtained from relapsed patients had increased autophagy levels than de novo AML cells.