MYC

[Oncogene] Scientists detected prominent RUNX3/Runx3 expression in human and mouse p53-deficient osteosarcoma and showed that p53 deficiency promoted osteosarcomagenesis in human and mouse by allowing Runx3 to induce oncogenic Myc expression.

[Journal of Biological Chemistry] Scientists examined for the first time the effect of N-myc-downregulated gene 1 (NDRG1) on androgen receptor expression, activation, and downstream signaling in LNCaP, 22Rv1 and C4-2B prostate cancer cell types.

[Journal of Translational Medicine] Scientists explored the function of circular RNA nucleolar and coiled-body phosphoprotein 1 (circNOLC1) in cancer stem cells of breast cancer and the inhibitory impact of propofol on circNOLC1.

[American Journal of Hematology] The authors developed a murine model to investigate the in vivo properties of human iPSC-red blood cells (RBCs). iPSC lines were produced from human peripheral blood mononuclear cells by transient expression of plasmids containing OCT4, SOX2, MYC, KLF4 and BCL-XL genes.

[Cancer Science] Researchers demonstrated that high expression of karyopherin α2 was positively correlated with radioresistance and CSC properties in lung adenocarcinoma cells.

[Journal of Experimental & Clinical Cancer Research] Gain or loss of functional leukemia cell models were produced, and in vitro and in vivo experiments were applied to demonstrate its leukemogenic phenotypes.