MYC

[Cell Death & Differentiation] Genetic ablation of OTUD6A efficiently repressed prostatic tumorigenesis of both human prostate cancer (PrCa) cells and the Hi-Myc transgenic PrCa mice, via reversing the metabolic remodeling caused by c-Myc overexpression in PrCa.

[Oncogene] Using breast cancer (BC) sphere cells as a model, researchers showed that BC stem-like cells expressed high levels of Myc, which required the presence of the multifunctional DNA/RNA binding protein Sam68 for the DNA-damage repair.

[Cell Reports] Researchers uncovered overexpression and gene copy-number alterations of nucleoporin-93 NUP93, a nuclear pore component, in aggressive human mammary tumors.

[Leukemia] Secondary transplantation from PDX and ΔPTEN models of T-cell acute lymphoblastic leukemia (T-ALL), confirmed delayed leukemia development and extended survival of mice engrafted with T-ALL from ARV-825 treated mice, providing functional confirmation of depletion of leukemia-initiating cells.

[Scientific Reports] The authors carried out genome-wide transcriptome analysis and discovered an lncRNA, EMSLR, which was induced both in lung adenocarcinoma and lung squamous cell carcinoma.

[Scientific Reports] Scientists explored clinical factors in 332 advanced NSCLC who received EGFR TKI and molecular characteristics through 65 whole exome sequencing of various EGFR TKI responses including; de novo, intermediate response and long-term response.