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MYC

Comparative Transcriptional Analyses of Preclinical Models and Patient Samples Reveal MYC and RELA Driven Expression Patterns That Define the Molecular Landscape of IBC

[npj Breast Cancer] The authors evaluated the transcriptome of an extended series of inflammatory breast cancer (IBC) preclinical models and performed a comparative analysis with patient samples to determine the extent to which the current models recapitulate the molecular characteristics of IBC observed clinically.

TRAF6 Functions as a Tumor Suppressor in Myeloid Malignancies by Directly Targeting MYC Oncogenic Activity

[Cell Stem Cell] To identify signaling states that cooperate with pre-leukemic cells, the authors used an in vivo RNAi screening approach and identified one of the most prominent genes as the ubiquitin ligase TRAF6.

Protooncogene MYC Drives Human Melanocyte Melanogenesis and Senescence

[Cancer Gene Therapy] Investigators overexpressed MYC in freshly isolated human primary melanocytes and studied the effects on melanocytic proliferation and differentiation.

Targeting of Noncoding RNAs Encoded by a Novel MYC Enhancers Inhibits the Proliferation of Human Hepatic Carcinoma Cells In Vitro

[Scientific Reports] By analyzing H3K27ac enrichment and enhancer RNA expression in cultured hepatocellular carcinoma cells, scientists identified six putative MYC enhancer regions.

CCND3 Is Indispensable for the Maintenance of B Cell Acute Lymphoblastic Leukemia

[Oncogenesis] Scientists demonstrated that CCND3 was essential for the proliferation and survival of B cell acute lymphoblastic leukemia, independent of the mutational background.

Genome-Wide Association Study on 13,167 Individuals Identifies Regulators of Blood CD34+ Cell Levels

[Blood] Scientists reported the first large-scale genome-wide association study on blood CD34+ cell levels. Across 13,167 individuals, they identified 9 significant and 2 suggestive associations, accounted for by 8 loci.

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