MYCN

[Nature Communications] The authors indicated that KDM6B promoted an oncogenic CDK4/6-pRB-E2F pathway in neuroblastoma cells via H3K27me3-dependent enhancer-promoter interactions.

[Nature Communications] Investigators investigated the contributions of chromatin regulatory complexes to fusion positive RMS (FP-RMS) tumor maintenance. They defined the mSWI/SNF functional repertoire in FP-RMS.

[Cell Biology and Toxicology] Researchers investigated its expression profile in neuroblastoma (NB), its association with NB clinical outcomes, and its influence in the regulation of cancer stem cells’ (CSCs) stemness maintenance.

[Oncogenesis] Researchers sugggested that alpha thalassemia mental retardation X-linked (ATRX) maintained genome integrity and p53 deficiency attenuated replication stress-induced DNA damage in neuroblastoma cells featuring inactivated ATRX by regulating DNA repair mechanisms.

[Nature Communications] Using multi-omics data, investigators demonstrated the existence of two retinoblastoma subtypes. They expressed markers of less differentiated cone together with neuronal/ganglion cell markers with marked inter- and intra-tumor heterogeneity.

[Cell Death & Disease] Genetic and pharmacological inhibition of dihydroorotate dehydrogenase suppressed the proliferation and tumorigenicity of MYCN-amplified neuroblastoma cell lines.