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MYCN

Intimal Sarcomas and Undifferentiated Cardiac Sarcomas Carry Mutually Exclusive MDM2, MDM4, and CDK6 Amplifications and Share a Common DNA Methylation Signature

[Modern Pathology] The authors reported a series of 35 cases comprising 25 intimal sarcomas (ISA) of the pulmonary artery, one ISA of the renal artery and nine undifferentiated pleomorphic sarcomas of the left atrium.

Restoration of the Molecular Clock Is Tumor Suppressive in Neuroblastoma

[Nature Communications] Scientists found that MYCN induced the expression of clock repressors and downregulated one of the clock activators by directly binding to their promoters

Temporal Evolution of Cellular Heterogeneity during the Progression to Advanced AR-Negative Prostate Cancer

[Nature Communications] Single-cell-based approaches revealed striking temporal changes to the transcriptome and chromatin accessibility which have identified the emergence of distinct cell populations, marked by differential expression of Ascl1 and Pou2f3, during the transition to neuroendocrine prostate cancer.

Concurrent Targeting of MAP3K3 and BRD4 by miR-3140-3p Overcomes Acquired Resistance to BET Inhibitors in Neuroblastoma Cells

[Molecular Therapy-Nucleic Acids] Investigators demonstrated that miR-3140-3p suppresses tumor cell growth in MYCN-amplified NB by downregulating MYCN and MYC through BRD4 suppression.

Catastrophic ATP Loss Underlies a Metabolic Combination Therapy Tailored for MYCN-Amplified Neuroblastoma

[Proceedings of the National Academy of Sciences of the United States of America] Investigators demonstrated that MYCN--amplified neuroblastomas were sensitive to the combined inhibition of MCT1 and complex I of the mitochondrion.

An ALYREF-MYCN Coactivator Complex Drives Neuroblastoma Tumorigenesis through Effects on USP3 and MYCN Stability

[Nature Communications] The authors identified ALYREF, expressed from the most common genetic copy number variation in neuroblastoma, chromosome 17q21-ter gain as a key regulator of MYCN protein turnover.

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