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Single-Cell Transcriptome Analysis Reveals Aberrant Stromal Cells and Heterogeneous Endothelial Cells in Alcohol-Induced Osteonecrosis of the Femoral Head

[Communications Biology] Scientists used single-cell RNA sequencing to explore the transcriptomic landscape of mid- and advanced-stage alcohol-induced osteonecrosis of the femoral head.

IP3R-Mediated Ca2+ Signaling Controls B Cell Proliferation through Metabolic Reprogramming

[iScience] Investigators demonstrated that IP3R-mediated Ca2+ signaling and calcineurin regulated B cell proliferation and survival by activating metabolic reprogramming in response to B cell receptor stimulation.

Sox9 Promotes Cardiomyocyte Apoptosis after Acute Myocardial Infarction by Promoting miR-223-3p and Inhibiting MEF2C

[Molecular Biotechnology] Researchers probe the role of Sox9 in cardiomyocyte apoptosis after acute myocardial infarction (AMI). AMI cell model was established in AC16 cells by hypoxia treatment.

MYOCD Is Required for Cardiomyocyte-Like Cells Induction from Human Urine Cells and Fibroblasts through Remodeling Chromatin

[Stem Cell Reviews and Reports] Researchers reported human urine cells could be converted into CM-like cells from different donors and the related chromatin accessibility dynamics by assay for transposase accessible chromatin-seq.

Hippo Pathway Effector Tead1 Induces Cardiac Fibroblast to Cardiomyocyte Reprogramming

[Journal of the American Heart Association] The conversion of fibroblasts into induced cardiomyocytes may regenerate myocardial tissue from cardiac scar through in situ cell transdifferentiation. Scientists explored the leveraging of Hippo pathway intermediates to enhance induced cardiomyocyte generation.

Fibroblast Transition to an Endothelial “Trans” State Improves Cell Reprogramming Efficiency

[Scientific Reports] Scientists explored a novel strategy leveraging endothelial cell plasticity to enhance reprogramming efficiency. Rat cardiac endothelial cells and fibroblasts were treated with Gata4, Mef2c, and Tbx5 to assess the cardio-differentiation potential of these cells.