Hippo Pathway Effector Tead1 Induces Cardiac Fibroblast to Cardiomyocyte Reprogramming

The conversion of fibroblasts into induced cardiomyocytes may regenerate myocardial tissue from cardiac scar through in situ cell transdifferentiation. Scientists explored the leveraging of Hippo pathway intermediates to enhance induced cardiomyocyte generation.
[Journal of the American Heart Association]
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Fibroblast Transition to an Endothelial “Trans” State Improves Cell Reprogramming Efficiency

Scientists explored a novel strategy leveraging endothelial cell plasticity to enhance reprogramming efficiency. Rat cardiac endothelial cells and fibroblasts were treated with Gata4, Mef2c, and Tbx5 to assess the cardio-differentiation potential of these cells.
[Scientific Reports]
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MicroRNA-190b Expression Predicts a Good Prognosis and Attenuates the Malignant Progression of Pancreatic Cancer by Targeting MEF2C and TCF4

Scientists examined the expression of miR‑190b in pancreatic cancer cell lines and tissues and evaluated its effects on cancer progression.
[Oncology Reports]
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Direct Reprogramming as a Route to Cardiac Repair

In recent years, direct reprogramming of resident cardiac fibroblasts to induced cardiac-like myocytes has emerged as a promising therapeutic strategy to repurpose the fibrotic response of the injured heart toward a functional myocardium.
[Seminars in Cell & Developmental Biology]
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Cadherin-13 Is a Critical Regulator of GABAergic Modulation in Human Stem-Cell-Derived Neuronal Networks

Scientists identified functional network parameters that are most reliably affected by GABAergic modulation as such, and through alterations of excitation/inhibition balance by reduced expression of Cadherin – 13 in GABAergic neurons.
[Molecular Psychiatry]
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Injectable Hydrogel for Co-Delivery of 5-Azacytidine in Zein Protein Nanoparticles with Stem Cells for Cardiac Function Restoration

Injectable alginate based microporous hydrogel were used to deliver 5-Azacytidine in zein protein nanoparticle with mesenchymal stem cells for attenuating adverse cardiac remodelling after myocardial infarction.
[International Journal of Pharmaceutics]
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Interactivity of Biochemical and Physical Stimuli during Epigenetic Conditioning and Cardiomyocytic Differentiation of Stem and Progenitor Cells Derived from Adult Hearts

Mixed populations of cardiosphere-derived stem and progenitor cells containing proliferative and cardiomyogenically committed cells were obtained from adult rat hearts.
[Integrative Biology]
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Long Non-Coding RNA Mir22hg-Derived miR-22-3p Promotes Skeletal Muscle Differentiation and Regeneration by Inhibiting HDAC4

Researchers identified a novel lncRNA, Mir22hg, that is significantly up-regulated during myoblast differentiation and is highly expressed in skeletal muscle. They validated that Mir22hg promotes the myoblasts differentiation, in vitro.
[Molecular Therapy-Nucleic Acids]
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BMP2-Dependent Gene Regulatory Network Analysis Reveals Klf4 as a Novel Transcription Factor of Osteoblast Differentiation

The BMP signaling pathway is widely regarded as one of the most important pathways in vertebrate skeletal biology, of which BMP2 is a potent inducer, governing the osteoblast differentiation of bone marrow stromal cells. Scientists used RNA-seq, ATAC-seq, and animal models to characterize the BMP2-dependent gene regulatory network governing osteoblast lineage commitment.
[Cell Death & Disease]
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MEF2C Shapes the Microtranscriptome during Differentiation of Skeletal Muscles

Deep sequencing of small RNAs of human muscle cells revealed a set of miRNAs, including several muscle-specific miRNAs, that were sensitive to myocyte enhancer factor 2C (MEF2C) depletion.
[Scientific Reports]
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Myocyte-Specific Enhancer Factor 2c Triggers Transdifferentiation of Adipose Tissue-Derived Stromal Cells into Spontaneously Beating Cardiomyocyte-Like Cells

Investigators developed a simple culture protocol under which the adult murine inguinal adipose tissue-derived stromal vascular fraction (Ad-SVF) reproducibly transdifferentiates into beating cardiomyocyte (CMs) without induction. The beating CMs showed the striated ventricular phenotype of cardiomyocytes and synchronised oscillation of the intracellular calcium concentration among cells on day 28 of Ad-SVF primary culture.
[Scientific Reports]
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