Tag Archives: Mef2c

Poly(ADP-Ribose) Polymerase 1 (PARP1) Restrains MyoD-Dependent Gene Expression during Muscle Differentiation

The authors observed that Poly(ADP-ribose) Polymerase 1 (PARP1) depletion boosted the up-regulation of MyoD targets, such as p57, myogenin, Mef2C and p21, while its re-expression reverted this effect. They also found that PARP1 interacted with some MyoD-binding regions and that its presence, independently of the enzymatic activity, interfered with MyoD recruitment and gene induction.
[Scientific Reports]
Matteini, F., Andresini, O., Petrai, S., Battistelli, C., Rossi, M. N., & Maione, R. (2020). Poly(ADP-ribose) Polymerase 1 (PARP1) restrains MyoD-dependent gene expression during muscle differentiation. Scientific Reports, 10(1), 15086. https://doi.org/10.1038/s41598-020-72155-8 Cite
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A Small Molecular Compound CC1007 Induces Cross-Lineage Differentiation by Inhibiting HDAC7 Expression and HDAC7/MEF2C Interaction in BCR-ABL− Pre-B-ALL

The authors investigated the anticancer effects of CC1007 in breakpoint cluster region-Abelson 1 fusion gene-negative (BCR-ABL1−) pre-B-ALL cell lines and primary patient-derived BCR-ABL1− pre-B-ALL cells.
[Cell Death & Disease]
Wang, Z., Zhang, Y., Zhu, S., Peng, H., Chen, Y., Cheng, Z., Liu, S., Luo, Y., Li, R., Deng, M., Xu, Y., Hu, G., Chen, L., & Zhang, G. (2020). A small molecular compound CC1007 induces cross-lineage differentiation by inhibiting HDAC7 expression and HDAC7/MEF2C interaction in BCR-ABL1 − pre-B-ALL. Cell Death & Disease, 11(9), 1–13. https://doi.org/10.1038/s41419-020-02949-1 Cite
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Genome-Wide Studies Reveal the Essential and Opposite Roles of ARID1A in Controlling Human Cardiogenesis and Neurogenesis from Pluripotent Stem Cells

The authors report ARID1A, a DNA-binding subunit of the SWI/SNF epigenetic complex, controls both neurogenesis and cardiogenesis from human embryonic stem cells through distinct mechanisms.
[Genome Biology]
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