Mef2c

[Communications Biology] Scientists used single-cell RNA sequencing to explore the transcriptomic landscape of mid- and advanced-stage alcohol-induced osteonecrosis of the femoral head.

[iScience] Investigators demonstrated that IP3R-mediated Ca2+ signaling and calcineurin regulated B cell proliferation and survival by activating metabolic reprogramming in response to B cell receptor stimulation.

[Molecular Biotechnology] Researchers probe the role of Sox9 in cardiomyocyte apoptosis after acute myocardial infarction (AMI). AMI cell model was established in AC16 cells by hypoxia treatment.

[Stem Cell Reviews and Reports] Researchers reported human urine cells could be converted into CM-like cells from different donors and the related chromatin accessibility dynamics by assay for transposase accessible chromatin-seq.

[Journal of the American Heart Association] The conversion of fibroblasts into induced cardiomyocytes may regenerate myocardial tissue from cardiac scar through in situ cell transdifferentiation. Scientists explored the leveraging of Hippo pathway intermediates to enhance induced cardiomyocyte generation.

[Scientific Reports] Scientists explored a novel strategy leveraging endothelial cell plasticity to enhance reprogramming efficiency. Rat cardiac endothelial cells and fibroblasts were treated with Gata4, Mef2c, and Tbx5 to assess the cardio-differentiation potential of these cells.