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Mef2c

MicroRNA-190b Expression Predicts a Good Prognosis and Attenuates the Malignant Progression of Pancreatic Cancer by Targeting MEF2C and TCF4

[Oncology Reports] Scientists examined the expression of miR‑190b in pancreatic cancer cell lines and tissues and evaluated its effects on cancer progression.

Direct Reprogramming as a Route to Cardiac Repair

[Seminars in Cell & Developmental Biology] In recent years, direct reprogramming of resident cardiac fibroblasts to induced cardiac-like myocytes has emerged as a promising therapeutic strategy to repurpose the fibrotic response of the injured heart toward a functional myocardium.

Cadherin-13 Is a Critical Regulator of GABAergic Modulation in Human Stem-Cell-Derived Neuronal Networks

[Molecular Psychiatry] Scientists identified functional network parameters that are most reliably affected by GABAergic modulation as such, and through alterations of excitation/inhibition balance by reduced expression of Cadherin - 13 in GABAergic neurons.

Injectable Hydrogel for Co-Delivery of 5-Azacytidine in Zein Protein Nanoparticles with Stem Cells for Cardiac Function Restoration

[International Journal of Pharmaceutics] Injectable alginate based microporous hydrogel were used to deliver 5-Azacytidine in zein protein nanoparticle with mesenchymal stem cells for attenuating adverse cardiac remodelling after myocardial infarction.

Interactivity of Biochemical and Physical Stimuli during Epigenetic Conditioning and Cardiomyocytic Differentiation of Stem and Progenitor Cells Derived from Adult Hearts

[Integrative Biology] Mixed populations of cardiosphere-derived stem and progenitor cells containing proliferative and cardiomyogenically committed cells were obtained from adult rat hearts.

Long Non-Coding RNA Mir22hg-Derived miR-22-3p Promotes Skeletal Muscle Differentiation and Regeneration by Inhibiting HDAC4

[Molecular Therapy-Nucleic Acids] Researchers identified a novel lncRNA, Mir22hg, that is significantly up-regulated during myoblast differentiation and is highly expressed in skeletal muscle. They validated that Mir22hg promotes the myoblasts differentiation, in vitro.

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