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NLRP3

LncRNA Rian Reduces Cardiomyocyte Pyroptosis and Alleviates Myocardial Ischemia–Reperfusion Injury by Regulating by the miR-17-5p/CCND1 Axis

[Hypertension Research] The authors investigated the mechanism of long noncoding RNAs Rian in myocardial ischemia–reperfusion injury-induced cardiomyocyte pyroptosis.

HDAC11 Promotes Both NLRP3/Caspase-1/GSDMD and Caspase-3/GSDME Pathways Causing Pyroptosis via ERG in Vascular Endothelial Cells

[Cell Death Discovery] Researchers investigated the role of histone deacetylase 11 (HDAC11) in vascular endothelial cell pyroptosis and its molecular mechanism.

Povidone Iodine Suppresses LPS-Induced Inflammation by Inhibiting TLR4/MyD88 Formation in Airway Epithelial Cells

[Scientific Reports] The authors explored the anti-inflammatory effects and underlying molecular mechanism of povidone-iodine (PVP-I) on lipopolysaccharide-stimulated airway epithelial cells and investigated whether nasal instillation of PVP-I could suppress mucosal inflammation in non-eosinophilic chronic rhinosinusitis mice.

Sestrin2 Protects against Cholestatic Liver Injury by Inhibiting Endoplasmic Reticulum Stress and NLRP3 Inflammasome-Mediated Pyroptosis

[Experimental and Molecular Medicine] Researchers investigated the role of hepatic Sestrin2 in cholestatic liver injury and its underlying mechanisms using in vivo and in vitro approaches.

Endothelial Cell Ferroptosis Mediates Monocrotaline-Induced Pulmonary Hypertension in Rats by Modulating NLRP3 Inflammasome Activation

[Scientific Reports] The effects of the ferroptosis inhibitor ferrostatin-1 on endothelial cell ferroptosis and pulmonary vascular remodelling in monocrotaline-induced rats were studied in vitro and in vivo.

Curcumin Mitigates TNFα-Induced Caco-2 Cell Monolayer Permeabilization through Modulation of NF-κB, ERK1/2 and JNK Pathways

[Molecular Nutrition & Food Research] Caco-2 cell monolayers were incubated with TNFα, in the absence or presence of curcumin. TNFα caused an increase in interleukin (IL)-6 and IL-8 release which was inhibited by curcumin in a dose-dependent manner

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