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NSCLC

Construction of ceRNA Network to Identify the lncRNA and mRNA Related to Non-Small Cell Lung Cancer

[PLoS One] The NSCLC tissue and normal tissue samples were screened for genetic comparison in the TCGA database. The predicted lncRNA and mRNA in BEAS2B and A549 cells were detected.

Lack of CD8+ T Cell Effector Differentiation during Priming Mediates Checkpoint Blockade Resistance in Non–Small Cell Lung Cancer

[Science Immunology] Researchers used an orthotopic non–small cell lung cancer mouse model to study immune checkpoint blockade-refractory CD8+ T cell responses.

NRG1 and NRG2 Fusions in Non-small Cell Lung Cancer (NSCLC): Seven Years between Lights and Shadows

[Expert Opinion On Therapeutic Targets] Fusions in neuregulin 1 (NRG1) and neuregulin 2 (NRG2) genes are molecular features of non-small cell lung cancer. These rearrangements enhance ectopic expression of the NRG/ErbB receptor‐ligand and induce the triggering of downstream pathways.

Periostin Secreted by Activated Fibroblasts in Idiopathic Pulmonary Fibrosis Promotes Tumorigenesis of Non-small Cell Lung Cancer

[Scientific Reports] Scientists investigated the possibility that periostin secreted by fibroblasts derived from idiopathic pulmonary fibrosis lung might have affected proliferation of non-small cell lung cancer cells.

Histone Deacetylase 6-Mediated Downregulation of TMEM100 Expedites the Development and Progression of Non-Small Cell Lung Cancer

[Human Cell] Researchers elucidated the role of histone deacetylase 6 in regulating epithelial-mesenchymal transition-mediated metastasis via mRNA in NSCLC.

Ultimovacs to Launch Phase II Combination Trial of UV1 in Lung Cancer (NSCLC)

[Ultimovacs ASA] Ultimovacs ASA announced that the company’s universal cancer vaccine, UV1, will be investigated in a new Phase II clinical trial in combination with pembrolizumab in NSCLC.

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