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Nanog

Increased Expression of PD-L1 in Endometrial Cancer Stem-Like Cells Is Regulated by Hypoxia

[Frontiers in Bioscience-Landmark] Using flow cytometry and western blot assays, the authors have demonstrated that programmed cell death ligand 1 expression is higher in endometrial cancer stem-like cell derived from endometrial cancer than in nonstem-like cancer cells.

MSC-Derived Extracellular Vesicle-Delivered L-PGDS Inhibit Gastric Cancer Progression by Suppressing Cancer Cell Stemness and STAT3 Phosphorylation

[Stem Cells International] Researchers explored whether Mesenchymal stem cell- (MSC-) derived extracellular vesicles-delivered lipocalin-type prostaglandin D2 synthase (L-PGDS) could inhibit gastric cancer progression.

Deregulation of the CD44-NANOG-MDR1 Associated Chemoresistance Pathways of Breast Cancer Stem Cells Potentiates the Anti-cancer Effect of Kaempferol in Synergism with Verapamil

[Toxicology and Applied Pharmacology] Researchers used Kaempferol in combination with Verapamil, in multiple assays to determine if there was an inhibitory effect on breast cancer stem cells.

ZFP207 Sustains Pluripotency by Coordinating OCT4 Stability, Alternative Splicing and RNA Export

[EMBO Reports] The authors employed multiple functional analyses to characterize the role of Zinc Finger Protein 207 (ZFP207) in mouse ESCs.

MACC1 Regulates the AKT/STAT3 Signaling Pathway to Induce Migration, Invasion, Cancer Stemness, and Suppress Apoptosis in Cervical Cancer Cells

[Bioengineered] Researchers verified that treatment with the STAT3 activator had significant reversal effects on the malignant behaviors of cervical cancer (CC) cells and CC stemness.

Differential Repression of Otx2 Underlies the Capacity of NANOG and ESRRB to Induce Germline Entry

[Stem Cell Reports] Investigators showed that NANOG mediated Otx2 downregulation in the absence of cytokines and that this was essential for primordial germ cell-like cells induction by NANOG.

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