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p57 Suppresses the Pluripotency and Proliferation of Mouse Embryonic Stem Cells by Positively Regulating p53 Activation

[Stem Cells International] Scientists discovered that p57Kip2 (p57), a cyclin-dependent kinase inhibitor canonically inhibiting cell proliferation, played a role in suppressing the pluripotency state of mouse ESCs.

The Opposing Action of Stromal Cell Proenkephalin and Stem Cell Transcription Factors in Prostate Cancer Differentiation

[BMC Cancer] Researchers found that prostate cancer cells appeared to retain their responsiveness to stromal proenkephalin (PENK) signaling. PENK could induce differentiation to counter de-differentiation caused by stem cell transcription factor activation.

MiR-199 Reverses the Resistance to Gemcitabine in Pancreatic Cancer by Suppressing Stemness through Regulating the Epithelial–Mesenchymal Transition

[ACS Omega] Researchers investigate the function of miR-199 on gemcitabine-resistance in pancreatic cancer, as well as the underlying mechanism.

Increased Proliferation and Differentiation Capacity of Placenta-Derived Mesenchymal Stem Cells from Women of Median Maternal Age Correlates with Telomere Shortening

[Aging] Researchers underscored the effect of maternal age on the biological characteristics and stemness properties of placenta-derived mesenchymal stem cells.

Increased Proliferation and Differentiation Capacity of Placenta-Derived Mesenchymal Stem Cells from Women of Median Maternal Age Correlates with Telomere Shortening

[Aging] Researchers investigated the effect of maternal age on the biological characteristics and stemness properties of placenta-derived MSCs (PDMSCs). PDMSCs were isolated from 5 donor age groups for comparison of morphological, proliferative and differentiation properties.

Pluripotency Transcription Factors at the Focus: The Phase Separation Paradigm in Stem Cells

[Biochemical Society Transactions] Scientists review the state-of-the-art knowledge of compartmentalization in the cell nucleus and the relevance of this process for transcriptional regulation, particularly in PSCs.

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