Nanog

[Reproductive Toxicology] The potential effect of fludioxonil on cardiac differentiation was evaluated in mouse ESCs. Exposure to fludioxonil resulted in reduced size of mouse embryoid bodies and induced increasing expression levels of the pluripotency markers Oct4, Sox2 and Nanog.

[Gene] Scientists evaluated the NANOG inhibition by siRNA and the increase of Let-7a by miRNA mimic in breast cancer cell lines and the effects of these changes on biologic aspects like apoptosis, stemness and invasion of these cells.

[Journal of Gastroenterology and Hepatology] Scientists investigated the Regorafenib resistance mechanism of CSCs in hepatocellular carcinoma. They used sphere formation and soft agar colony formation assays to evaluate the stemness capacity of cancer cells.

[Genes & Development] The authors showed that conditional Satb2 gene inactivation weakened ESC pluripotency, and identified SUMO2 modification of SATB2 by the E3 ligase ZFP451 as a potential driver of ESC differentiation.

[Stem Cell Research & Therapy] Researchers compared the cytoprotection between peritoneal dialysis (PD) effluent-derived MSCs and umbilical cord-derived MSCs in the treatment of both peritoneal membrane and kidney injury in uremic rats with chronic PD.

[Cancer Cell International] Long non-coding RNAs and miRs are differentially expressed in ovarian cancer (OC) cells and influence OC progression. Investigators explored the underlying roles of LINC00115 and miR-30a in OC.