Comparison of Mesenchymal Stromal Cells from Peritoneal Dialysis Effluent with Those from Umbilical Cords: Characteristics and Therapeutic Effects on Chronic Peritoneal Dialysis in Uremic Rats

Researchers compared the cytoprotection between peritoneal dialysis (PD) effluent-derived MSCs and umbilical cord-derived MSCs in the treatment of both peritoneal membrane and kidney injury in uremic rats with chronic PD.
[Stem Cell Research & Therapy]
Du, Y., Zong, M., Guan, Q., Huang, Z., Zhou, L., Cai, J., da Roza, G., Wang, H., Qi, H., Lu, Y., & Du, C. (2021). Comparison of mesenchymal stromal cells from peritoneal dialysis effluent with those from umbilical cords: characteristics and therapeutic effects on chronic peritoneal dialysis in uremic rats. Stem Cell Research & Therapy, 12(1), 398. https://doi.org/10.1186/s13287-021-02473-9 Cite
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Neutrophil Oxidative Stress Mediates Obesity-Associated Vascular Dysfunction and Metastatic Transmigration

Scientists showed that obesity led to neutrophil-dependent impairment of vascular integrity through loss of endothelial adhesions, enabling cancer cell extravasation into the lung.
[Nature Cancer]
McDowell, S. A. C., Luo, R. B. E., Arabzadeh, A., Doré, S., Bennett, N. C., Breton, V., Karimi, E., Rezanejad, M., Yang, R. R., Lach, K. D., Issac, M. S. M., Samborska, B., Perus, L. J. M., Moldoveanu, D., Wei, Y., Fiset, B., Rayes, R. F., Watson, I. R., Kazak, L., … Quail, D. F. (2021). Neutrophil oxidative stress mediates obesity-associated vascular dysfunction and metastatic transmigration. Nature Cancer, 1–18. https://doi.org/10.1038/s43018-021-00194-9 Cite
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Mechanistic and Therapeutic Distinctions between Cardiosphere-Derived Cell and Mesenchymal Stem Cell Extracellular Vesicle Non-Coding RNA

Investigators compared extracellular vesicles derived from multiple human mesenchymal stem cell and cardiosphere-derived cell donors using diverse in vitro and in vivo assays.
[Scientific Reports]
Walravens, A.-S., Smolgovsky, S., Li, L., Kelly, L., Antes, T., Peck, K., Quon, T., Ibrahim, A., Marbán, E., Berman, B., Marbán, L., R.-Borlado, L., & de Couto, G. (2021). Mechanistic and therapeutic distinctions between cardiosphere-derived cell and mesenchymal stem cell extracellular vesicle non-coding RNA. Scientific Reports, 11(1), 8666. https://doi.org/10.1038/s41598-021-87939-9 Cite
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Islet Neogenesis Associated Protein (INGAP) Protects Pancreatic β Cells from IL-1β and IFNγ-Induced Apoptosis

Researchers determined whether recombinant Islet NeoGenesis Associated Protein (rINGAP) and its active core, a pentadecapeptide INGAP104–118, protected β cells against cytokine-induced death.
[Cell Death Discovery]
Nano, E., Petropavlovskaia, M., & Rosenberg, L. (2021). Islet neogenesis associated protein (INGAP) protects pancreatic β cells from IL-1β and IFNγ-induced apoptosis. Cell Death Discovery, 7(1), 1–15. https://doi.org/10.1038/s41420-021-00441-z Cite
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LECT2 as a Hepatokine Links Liver Steatosis to Inflammation via Activating Tissue Macrophages in NASH

Hepatic expression of leukocyte cell-derived chemotaxin 2 (LECT2) was upregulated in association with the inflammatory signature in human liver tissues. The elevation of LECT2 shifted liver residual macrophage to the M1-like phenotype, and contributed to the development of liver inflammation.
[Scientific Reports]
Takata, N., Ishii, K., Takayama, H., Nagashimada, M., Kamoshita, K., Tanaka, T., Kikuchi, A., Takeshita, Y., Matsumoto, Y., Ota, T., Yamamoto, Y., Yamagoe, S., Seki, A., Sakai, Y., Kaneko, S., & Takamura, T. (2021). LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH. Scientific Reports, 11(1), 555. https://doi.org/10.1038/s41598-020-80689-0 Cite
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Nitric Oxide-Targeted Therapy Inhibits Stemness and Increases the Efficacy of Tamoxifen in Estrogen Receptor-Positive Breast Cancer Cells

Researchers explored whether targeting nitric oxide in estrogen positive breast cancer cells impacts cancer stem cell subpopulation and sensitivity to hormonal therapy with tamoxifen.
[Laboratory Investigation]
López-Sánchez, L. M., Mena, R., Guil-Luna, S., Mantrana, A., Peñarando, J., Toledano-Fonseca, M., Conde, F., De la Haba-Rodríguez, J. R., Aranda, E., & Rodríguez-Ariza, A. (2020). Nitric oxide-targeted therapy inhibits stemness and increases the efficacy of tamoxifen in estrogen receptor-positive breast cancer cells. Laboratory Investigation, 1–12. https://doi.org/10.1038/s41374-020-00507-z Cite
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Xeno-Free Condition Enhances Therapeutic Functions of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells against Experimental Colitis by Upregulated Indoleamine 2,3-Dioxygenase Activity

Researcchers extensively compared the physiological functions of human Wharton’s jelly-derived mesenchymal stem cells in a xeno-free medium and a medium containing 10% fetal bovine serum.
[Journal of Clinical Medicine]

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IL-17F Induces Inflammation, Dysfunction and Cell Death in Mouse Islets

IL-17F possessed similar pathogenic activities to IL-17A in mouse β-cell lines and islets and was likely to be a type 17 associated pathogenic factor in type 1 diabetes.
[Scientific Reports]
Catterall, T., Fynch, S., Kay, T. W. H., Thomas, H. E., & Sutherland, A. P. R. (2020). IL-17F induces inflammation, dysfunction and cell death in mouse islets. Scientific Reports, 10(1), 13077. https://doi.org/10.1038/s41598-020-69805-2 Cite
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