LECT2 as a Hepatokine Links Liver Steatosis to Inflammation via Activating Tissue Macrophages in NASH

Hepatic expression of leukocyte cell-derived chemotaxin 2 (LECT2) was upregulated in association with the inflammatory signature in human liver tissues. The elevation of LECT2 shifted liver residual macrophage to the M1-like phenotype, and contributed to the development of liver inflammation.
[Scientific Reports]
Takata, N., Ishii, K., Takayama, H., Nagashimada, M., Kamoshita, K., Tanaka, T., Kikuchi, A., Takeshita, Y., Matsumoto, Y., Ota, T., Yamamoto, Y., Yamagoe, S., Seki, A., Sakai, Y., Kaneko, S., & Takamura, T. (2021). LECT2 as a hepatokine links liver steatosis to inflammation via activating tissue macrophages in NASH. Scientific Reports, 11(1), 555. https://doi.org/10.1038/s41598-020-80689-0 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Nitric Oxide-Targeted Therapy Inhibits Stemness and Increases the Efficacy of Tamoxifen in Estrogen Receptor-Positive Breast Cancer Cells

Researchers explored whether targeting nitric oxide in estrogen positive breast cancer cells impacts cancer stem cell subpopulation and sensitivity to hormonal therapy with tamoxifen.
[Laboratory Investigation]
López-Sánchez, L. M., Mena, R., Guil-Luna, S., Mantrana, A., Peñarando, J., Toledano-Fonseca, M., Conde, F., De la Haba-Rodríguez, J. R., Aranda, E., & Rodríguez-Ariza, A. (2020). Nitric oxide-targeted therapy inhibits stemness and increases the efficacy of tamoxifen in estrogen receptor-positive breast cancer cells. Laboratory Investigation, 1–12. https://doi.org/10.1038/s41374-020-00507-z Cite
Abstract
Bookmark

No account yet? Register

0
Share

Xeno-Free Condition Enhances Therapeutic Functions of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells against Experimental Colitis by Upregulated Indoleamine 2,3-Dioxygenase Activity

Researcchers extensively compared the physiological functions of human Wharton’s jelly-derived mesenchymal stem cells in a xeno-free medium and a medium containing 10% fetal bovine serum.
[Journal of Clinical Medicine]
Kang, J. Y., Oh, M.-K., Joo, H., Park, H. S., Chae, D.-H., Kim, J., Lee, H.-R., Oh, I.-H., & Yu, K.-R. (2020). Xeno-Free Condition Enhances Therapeutic Functions of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells against Experimental Colitis by Upregulated Indoleamine 2,3-Dioxygenase Activity. Journal of Clinical Medicine, 9(9), 2913. https://doi.org/10.3390/jcm9092913 Cite
Full Article
Bookmark

No account yet? Register

0
Share

IL-17F Induces Inflammation, Dysfunction and Cell Death in Mouse Islets

IL-17F possessed similar pathogenic activities to IL-17A in mouse β-cell lines and islets and was likely to be a type 17 associated pathogenic factor in type 1 diabetes.
[Scientific Reports]
Catterall, T., Fynch, S., Kay, T. W. H., Thomas, H. E., & Sutherland, A. P. R. (2020). IL-17F induces inflammation, dysfunction and cell death in mouse islets. Scientific Reports, 10(1), 13077. https://doi.org/10.1038/s41598-020-69805-2 Cite
Full Article
Bookmark

No account yet? Register

0
Share
Share