MYH9 Is Crucial for Stem Cell-Like Properties in Non-Small Cell Lung Cancer by Activating mTOR Signaling

The authors found that the stemness characteristics of lung cancer cells were significantly enhanced by the overexpression of non-muscle myosin heavy chain 9 (MYH9), and the knockout of MYH9 had the opposite effects.
[Cell Death Discovery]
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Generation of a Transgenic Mouse Embryonic Stem Cell Line Expressing Dnmt1Y495C Mutation Associated with HSAN1E Disorder

Researchers employed non-homologous recombination and generated a mouse ESC line carrying a transgene expressing DNMT1 Y495C mutation in the wild-type background as a model for studying the abnormal neurogenesis due to this mutation.
[Stem Cell Research]
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Atypical Cyclin P Regulates Cancer Cell Stemness through Activation of the WNT Pathway

Cell line-derived spheroids, ex vivo intestinal organoid cultures and induced-pluripotent stem cells were used to investigate the role of atypical cyclin P in stemness.
[Cellular Oncology]
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Loss of Resf1 Reduces the Efficiency of Embryonic Stem Cell Self-Renewal and Germline Entry

The authors used Resf1 knockout cell lines to determine the requirements of RESF1 for ESC self-renewal and for in vitro specification of ESCs into primordial germ cell-like cells
[Life Science Alliance]
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Effects of 2,2′,4,4′-Tetrabromodiphenyl Ether on the Development of Mouse Embryonic Stem Cells

To explore the developmental toxicity of 2,2′,4,4′-Tetrabromodiphenyl ether (BDE47), mouse ESCs, which are ideal models for testing the developmental toxicity of environmental contaminants in vitro, were exposed to BDE47 for 24 h or 48 h in this study.
[Reproductive Toxicology]
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HN1L Promotes Stem Cell-Like Properties by Regulating TGF-β Signaling Pathway through Targeting FOXP2 in Prostate Cancer

CD133+ cells were sorted from prostate cancer cells using magnetic fluorescence cell sorting technology and were considered as cancer stem cells.
[Cell Biology International]
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The Combined Action of Esrrb and Nr5a2 Is Essential for Murine Naïve Pluripotency

Researchers reported that the conjunct activity of two orphan nuclear receptors, Esrrb and Nr5a2, paralleled the importance of that of Oct4 and Sox2 in naïve mouse ESCs. By occupying a large common set of regulatory elements, these two factors controlled the binding of Oct4, Sox2 and Nanog to DNA.
[Development]
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MicroRNA-148a/152 Cluster Restrains Tumor Stem Cell Phenotype of Colon Cancer via Modulating CCT6A

Colon cancer stem cells were selected and high/low expression of miR-148a/152 plasmids were synthesized to intervene CD44+/CD133+ colon cancer stem cells to investigate the function of miR-148a/152 in invasion, migration, proliferation, colony formation and apoptosis of cells.
[Anti-Cancer Drugs]
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The Aryl Hydrocarbon Receptor Promotes Differentiation during Mouse Preimplantational Embryo Development

Scientists showed that AhR regulated pluripotency factors and maintained the metabolic activity required for proper embryo differentiation. AhR-lacking embryos showed a pluripotent phenotype characterized by a delayed expression of trophectoderm differentiation markers.
[Stem Cell Reports]
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Identification of New Transcription Factors that Can Promote Pluripotent Reprogramming

The chromatin accessibility and transcriptional level of human ESCs and human urine cells were compared by Assay for Transposase-Accessible Chromatin with high-throughput sequencing and RNA sequencing RNA-seq to identify potential reprogramming factors.
[Stem Cell Reviews and Reports]
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OCT4 Cooperates with Distinct ATP-Dependent Chromatin Remodelers in Naïve and Primed Pluripotent States in Human

Researchers mapped the OCT4 interactomes in naïve and primed human ESCs (hESCs), revealing extensive connections to mammalian ATP-dependent nucleosome remodeling complexes. In naïve hESCs, OCT4 was associated with both BRG1 and BRM, the two paralog ATPases of the BAF complex.
[Nature Communications]
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