Tag results:
Oct4
Cancer Stem Cell News
MicroRNA-148a/152 Cluster Restrains Tumor Stem Cell Phenotype of Colon Cancer via Modulating CCT6A
[Anti-Cancer Drugs] Colon cancer stem cells were selected and high/low expression of miR-148a/152 plasmids were synthesized to intervene CD44+/CD133+ colon cancer stem cells to investigate the function of miR-148a/152 in invasion, migration, proliferation, colony formation and apoptosis of cells.
ESC & iPSC News
The Aryl Hydrocarbon Receptor Promotes Differentiation during Mouse Preimplantational Embryo Development
[Stem Cell Reports] Scientists showed that AhR regulated pluripotency factors and maintained the metabolic activity required for proper embryo differentiation. AhR-lacking embryos showed a pluripotent phenotype characterized by a delayed expression of trophectoderm differentiation markers.
ESC & iPSC News
Identification of New Transcription Factors that Can Promote Pluripotent Reprogramming
[Stem Cell Reviews and Reports] The chromatin accessibility and transcriptional level of human ESCs and human urine cells were compared by Assay for Transposase-Accessible Chromatin with high-throughput sequencing and RNA sequencing RNA-seq to identify potential reprogramming factors.
ESC & iPSC News
OCT4 Cooperates with Distinct ATP-Dependent Chromatin Remodelers in Naïve and Primed Pluripotent States in Human
[Nature Communications] Researchers mapped the OCT4 interactomes in naïve and primed human ESCs (hESCs), revealing extensive connections to mammalian ATP-dependent nucleosome remodeling complexes. In naïve hESCs, OCT4 was associated with both BRG1 and BRM, the two paralog ATPases of the BAF complex.
ESC & iPSC News
Chromatin lncRNA Platr10 Controls Stem Cell Pluripotency by Coordinating an Intrachromosomal Regulatory Network
[Genome Biology] Scientists used a novel chromatin RNA in situ reverse transcription sequencing approach to profile long noncoding RNAs in the Oct4 promoter.
Prostate Cell News
Reduced DAPK1 Expression Promotes Stem Cell-Like Characteristics of Prostate Cancer Cells by Activating ZEB1 via Hippo/YAP Signaling Pathway
[Stem Cells and Development] Compared with tumor-adjacent normal tissues, death-associated protein kinase 1 (DAPK1) expression was reduced in prostate cancer cell lines with respect to that in normal prostate cells.