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Oct4

MicroRNA-148a/152 Cluster Restrains Tumor Stem Cell Phenotype of Colon Cancer via Modulating CCT6A

[Anti-Cancer Drugs] Colon cancer stem cells were selected and high/low expression of miR-148a/152 plasmids were synthesized to intervene CD44+/CD133+ colon cancer stem cells to investigate the function of miR-148a/152 in invasion, migration, proliferation, colony formation and apoptosis of cells.

The Aryl Hydrocarbon Receptor Promotes Differentiation during Mouse Preimplantational Embryo Development

[Stem Cell Reports] Scientists showed that AhR regulated pluripotency factors and maintained the metabolic activity required for proper embryo differentiation. AhR-lacking embryos showed a pluripotent phenotype characterized by a delayed expression of trophectoderm differentiation markers.

Identification of New Transcription Factors that Can Promote Pluripotent Reprogramming

[Stem Cell Reviews and Reports] The chromatin accessibility and transcriptional level of human ESCs and human urine cells were compared by Assay for Transposase-Accessible Chromatin with high-throughput sequencing and RNA sequencing RNA-seq to identify potential reprogramming factors.

OCT4 Cooperates with Distinct ATP-Dependent Chromatin Remodelers in Naïve and Primed Pluripotent States in Human

[Nature Communications] Researchers mapped the OCT4 interactomes in naïve and primed human ESCs (hESCs), revealing extensive connections to mammalian ATP-dependent nucleosome remodeling complexes. In naïve hESCs, OCT4 was associated with both BRG1 and BRM, the two paralog ATPases of the BAF complex.

Chromatin lncRNA Platr10 Controls Stem Cell Pluripotency by Coordinating an Intrachromosomal Regulatory Network

[Genome Biology] Scientists used a novel chromatin RNA in situ reverse transcription sequencing approach to profile long noncoding RNAs in the Oct4 promoter.

Reduced DAPK1 Expression Promotes Stem Cell-Like Characteristics of Prostate Cancer Cells by Activating ZEB1 via Hippo/YAP Signaling Pathway

[Stem Cells and Development] Compared with tumor-adjacent normal tissues, death-associated protein kinase 1 (DAPK1) expression was reduced in prostate cancer cell lines with respect to that in normal prostate cells.

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