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PBMCs

Activated but Functionally Impaired Memory Tregs Are Expanded in Slow Progressors to Type 1 Diabetes

[Diabetologia] Researchers profiled CD4+ regulatory T cells in a small but well-characterized cohort of extreme slow progressors with a median age 43, followed up for 18–32 years.

Comprehensive Investigations Revealed Consistent Pathophysiological Alterations after Vaccination with COVID-19 Vaccines

[Cell Discovery] Scientists reported, besides generation of neutralizing antibodies, consistent alterations in hemoglobin A1c, serum sodium and potassium levels, coagulation profiles, and renal functions in healthy volunteers after vaccination with an inactivated SARS-CoV-2 vaccine.

Nanobody-Based CTLA4 Inhibitors for Immune Checkpoint Blockade Therapy of Canine Cancer Patients

[Scientific Reports] The authors developed, characterized and assessed whether chimeric heavy chain only antibodies against CTLA4 were viable therapeutic candidates for the treatment of canine cancers.

Oestrogen Deprivation Induces Chemokine Production and Immune Cell Recruitment in In Vitro and In Vivo Models of Oestrogen Receptor-Positive Breast Cancer

[Breast Cancer Research] Scientists investigated the effect of oestrogen deprivation on the expression of chemokines and immune infiltration in vitro and in an ER+ immunocompetent mouse model.

Endometrial Mesenchymal Stem/Stromal Cells: The Enigma to Code Messages for Generation of Functionally Active Regulatory T Cells

[Stem Cell Research & Therapy] The effect of MSCs on proliferation of anti-CD3/CD28-stimulated T CD4+ cells and generation of Tregs with or without pre-treatment with mitomycin C, IFN-γ and IL-1β was evaluated by flow cytometry.

Intrauterine Administration of Peripheral Blood Mononuclear Cells (PBMCs) Improves Embryo Implantation in Mice by Regulating Local Treg/Th17 Cell Balance

[Journal of Reproduction and Development] Investigators determined the effect of intrauterine administration of mouse PBMCs prior to embryo implantation on endometrial receptivity and embryo implantation, and examined the underlying mechanism of Treg/Th17 cell balance following intrauterine administration of PBMCs.

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