Tag results:
PDAC cells
Pancreatic Cell News
Isoforms of the Orphan Nuclear Receptor COUP-TFII Differentially Modulate Pancreatic Cancer Progression
[International Journal of Oncology] It was demonstrated that COUP‑TFII_V2 naturally occured in PDAC cells and in primary samples, where its expression was consistent with shorter overall survival and peripheral invasion.
Pancreatic Cell News
The Human AP-Endonuclease 1 (APE1) Is a DNA G-quadruplex Structure Binding Protein and Regulates KRAS Expression in Pancreatic Ductal Adenocarcinoma Cells
[Nucleic Acids Research] The authors showed that APE1 (apurinic/apyrimidinic endonuclease 1), a multifunctional DNA repair enzyme, is a G4-binding protein, and loss of APE1 abrogated the formation of stable G4 structures in cells.
Pancreatic Cell News
UHMK1 Is a Novel Marker for Personalized Prediction of Pancreatic Cancer Prognosis
[Frontiers in Oncology] UHMK1 expression was enhanced in PDAC, and high UHMK1 expression correlated with tumor stage, and lower overall survival.
Pancreatic Cell News
Pseudogene AK4P1 Promotes Pancreatic Ductal Adenocarcinoma Progression through Relieving miR-375-Mediated YAP1 Degradation
[Aging] Scientists characterized a novel pseudogene-miRNA-mRNA network associated with PDAC progression using bioinformatics analysis. After screening by dreamBase and GEPIA, 12 up-regulated and 7 down-regulated differentially expressed pseudogenes were identified.
Pancreatic Cell News
Lucidone Inhibits Autophagy and MDR1 via HMGB1/RAGE/PI3K/Akt Signaling Pathway in Pancreatic Cancer Cells
[Phytotherapy Research] Investigators explored the function of lucidone in tumor cytotoxicity and chemosensitivity through the suppression of receptor for advanced glycation end products-initiated signaling in pancreatic ductal adenocarcinoma cells.
Cancer Stem Cell News
The Significance of ErbB2/3 in the Conversion of Induced Pluripotent Stem Cells into Cancer Stem Cells
[Scientific Reports] Scientists established a novel method to generate CSCs from iPSCs under a cancerous microenvironment mimicked by the conditioned medium of cancer-derived cells.