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PDAC cells

Isoforms of the Orphan Nuclear Receptor COUP-TFII Differentially Modulate Pancreatic Cancer Progression

[International Journal of Oncology] It was demonstrated that COUP‑TFII_V2 naturally occured in PDAC cells and in primary samples, where its expression was consistent with shorter overall survival and peripheral invasion.

The Human AP-Endonuclease 1 (APE1) Is a DNA G-quadruplex Structure Binding Protein and Regulates KRAS Expression in Pancreatic Ductal Adenocarcinoma Cells

[Nucleic Acids Research] The authors showed that APE1 (apurinic/apyrimidinic endonuclease 1), a multifunctional DNA repair enzyme, is a G4-binding protein, and loss of APE1 abrogated the formation of stable G4 structures in cells.

UHMK1 Is a Novel Marker for Personalized Prediction of Pancreatic Cancer Prognosis

[Frontiers in Oncology] UHMK1 expression was enhanced in PDAC, and high UHMK1 expression correlated with tumor stage, and lower overall survival.

Pseudogene AK4P1 Promotes Pancreatic Ductal Adenocarcinoma Progression through Relieving miR-375-Mediated YAP1 Degradation

[Aging] Scientists characterized a novel pseudogene-miRNA-mRNA network associated with PDAC progression using bioinformatics analysis. After screening by dreamBase and GEPIA, 12 up-regulated and 7 down-regulated differentially expressed pseudogenes were identified.

Lucidone Inhibits Autophagy and MDR1 via HMGB1/RAGE/PI3K/Akt Signaling Pathway in Pancreatic Cancer Cells

[Phytotherapy Research] Investigators explored the function of lucidone in tumor cytotoxicity and chemosensitivity through the suppression of receptor for advanced glycation end products-initiated signaling in pancreatic ductal adenocarcinoma cells.

The Significance of ErbB2/3 in the Conversion of Induced Pluripotent Stem Cells into Cancer Stem Cells

[Scientific Reports] Scientists established a novel method to generate CSCs from iPSCs under a cancerous microenvironment mimicked by the conditioned medium of cancer-derived cells.

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