PDAC cells

[Journal of Cellular Biochemistry] Researchers examined the role of Bcl2-associated athanogene (BAG3) to activate human fibroblasts in releasing cytokines capable of supporting tumor progression.

[Cell Biology and Toxicology] Constitutive activation of NF-κB is frequently observed in pancreatic ductal adenocarcinoma (PDAC). Scientists found that YEATS2, a scaffolding protein of ATAC complex, was highly expressed in human PDAC.

[Experimental & Molecular Medicine] Correlations of KLF10 deficiency with rapid metastasis, elevated EMT, and glycolysis were demonstrated in resected pancreatic adenocarcinoma tissues, in vitro assays, and murine models.

[Cell Reports] Researchers used marker-independent stochastic clonal labeling, combined with quantitative modeling of tumor expansion, to uncover pancreatic ductal adenocarcinoma tissue growth dynamics.

[Oncogene] Researchers showed that the restoration of wild type (WT) KRAS expression in human pancreatic ductal adenocarcinoma (PDAC) cell lines with LOH at KRAS significantly attenuated the malignancy of PDAC cells both in vitro and in vivo, demonstrating a tumor-suppressive role of the WT KRAS allele.

[Pancreas] Adopting a 3D rotary cell culture system, researchers co-cultured several PDAC cell lines and MIN6 islet β cells.