Cleavage of Proteoglycans, Plasma Proteins and the Platelet-Derived Growth Factor Receptor in the Hemorrhagic Process Induced by Snake Venom Metalloproteinases

The authors outlined the multifactorial character of snake venom metalloproteinases (SVMP)-induced tissue damage, including the transient activation of tissue proteinases, and underscore for the first time that endothelial glycocalyx proteoglycans and PDGFR are targets of SVMPs in the disruption of microvasculature integrity and generation of hemorrhage.
[Scientific Reports]
Asega, A. F., Menezes, M. C., Trevisan-Silva, D., Cajado-Carvalho, D., Bertholim, L., Oliveira, A. K., Zelanis, A., & Serrano, S. M. T. (2020). Cleavage of proteoglycans, plasma proteins and the platelet-derived growth factor receptor in the hemorrhagic process induced by snake venom metalloproteinases. Scientific Reports, 10(1), 12912. https://doi.org/10.1038/s41598-020-69396-y Cite
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Roseotoxin B Alleviates Cholestatic Liver Fibrosis through Inhibiting PDGF-B/PDGFR-β Pathway in Hepatic Stellate Cells

Roseotoxin B was shown to possess an improving effect on cholestatic liver fibrosis in bile duct–ligated mice, as proved by histochemical and immunohistochemical staining, hepatic biochemical parameters, and TUNEL apoptotic cell detection in tissue sections.
[Cell Death & Disease]
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