All-Trans Retinoic Acid Prevented Vein Grafts Stenosis by Inhibiting Rb-E2F Mediated Cell Cycle Progression and KLF5-RARα Interaction in Human Vein Smooth Muscle Cells

All-trans retinoic acid (ATRA) could repress the PDGF-bb-induced excessive proliferation and migration of human umbilical vein smooth muscle cells, which was mediated by Rb-E2F dependent cell cycle inhibition.
[Cardiovascular Drugs and Therapy]
Yu, Y., Wang, Y., Fei, X., Song, Z., Xie, F., Yang, F., Liu, X., Xu, Z., & Wang, G. (2020). All-Trans Retinoic Acid Prevented Vein Grafts Stenosis by Inhibiting Rb-E2F Mediated Cell Cycle Progression and KLF5-RARα Interaction in Human Vein Smooth Muscle Cells. Cardiovascular Drugs and Therapy. https://doi.org/10.1007/s10557-020-07089-4 Cite
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Dermal Fibroblasts Have Different Extracellular Matrix Profiles Induced by TGF-β, PDGF and IL-6 in a Model for Skin Fibrosis

Researchers investigated the expression of extracellular matrix by dermal fibroblast mimicking fibrotic skin diseases as systemic sclerosis using clinically validated biomarkers.
[Scientific Reports]
Juhl, P., Bondesen, S., Hawkins, C. L., Karsdal, M. A., Bay-Jensen, A.-C., Davies, M. J., & Siebuhr, A. S. (2020). Dermal fibroblasts have different extracellular matrix profiles induced by TGF-β, PDGF and IL-6 in a model for skin fibrosis. Scientific Reports, 10(1), 17300. https://doi.org/10.1038/s41598-020-74179-6 Cite
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SHP2 Is a Multifunctional Therapeutic Target in Drug Resistant Metastatic Breast Cancer

Scientists used inducible genetic depletion and two distinct pharmacological inhibitors to investigate the therapeutic potential of targeting SH2 containing protein tyrosine phosphatase-2 (SHP2) in metastatic breast cancer.
[Oncogene]
Chen, H., Libring, S., Ruddraraju, K. V., Miao, J., Solorio, L., Zhang, Z.-Y., & Wendt, M. K. (2020). SHP2 is a multifunctional therapeutic target in drug resistant metastatic breast cancer. Oncogene, 1–15. https://doi.org/10.1038/s41388-020-01488-5 Cite
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Human Amniotic Fluid Stem Cells Attenuate Cholangiocyte Apoptosis in a Bile Duct Injury Model of Liver Ductal Organoids

Researchers investigated whether human amniotic fluid stem cells have the potential to attenuate cholangiocyte apoptosis and injury induced fibrogenic response in an ex vivo bile duct injury model of liver ductal organoids.
[Journal of Pediatric Surgery]
Chusilp, S., Lee, C., Li, B., Lee, D., Yamoto, M., Ganji, N., Vejchapipat, P., & Pierro, A. (2020). Human Amniotic Fluid Stem Cells Attenuate Cholangiocyte Apoptosis in a Bile Duct Injury Model of Liver Ductal Organoids. Journal of Pediatric Surgery. https://doi.org/10.1016/j.jpedsurg.2020.09.043 Cite
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HbF Levels in Sickle Cell Disease Are Associated with Proportion of Circulating Hematopoietic Stem and Progenitor Cells and CC-Chemokines

Researchers report that the proportions of Lin-CD34+38 hematopoietic multipotent cells and of Lin-CD34+CD38+ hematopoietic progenitors cells are highly variable between individuals but stable over long periods of time, in both healthy individuals and sickle cell disease patients.
[Cells]
Minniti, C. P., Tolu, S. S., Wang, K., Yan, Z., Robert, K., Zhang, S., Crouch, A. S., Uehlinger, J., Manwani, D., & Bouhassira, E. E. (2020). HbF Levels in Sickle Cell Disease Are Associated with Proportion of Circulating Hematopoietic Stem and Progenitor Cells and CC-Chemokines. Cells, 9(10), 2199. https://doi.org/10.3390/cells9102199 Cite
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Multiplexed Analysis of Neural Cytokine Signaling by a Novel Neural Cell–Cell Interaction Microchip

The authors generated a neural cell-cell interaction microchip as an in vitro platform to simultaneously track an informed panel of cytokines and co-evaluate cell morphology and biomarker expression coupled to a sandwich ELISA platform.
[Lab on a Chip]
Abdullah, M. A. A., Amini, N., Yang, L., Paluh, J. L., & Wang, J. (2020). Multiplexed analysis of neural cytokine signaling by a novel neural cell–cell interaction microchip. Lab on a Chip. https://doi.org/10.1039/D0LC00401D Cite
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Transplantation of Human Amnion Epithelial Cells Improves Endometrial Regeneration in Rat Model of Intrauterine Adhesions

Investigators found that PKH26-labeled human amniotic epithelial cells mainly distributed in the basal layer of endometrium after transplantation.
[Stem Cells and Development]
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Cleavage of Proteoglycans, Plasma Proteins and the Platelet-Derived Growth Factor Receptor in the Hemorrhagic Process Induced by Snake Venom Metalloproteinases

The authors outlined the multifactorial character of snake venom metalloproteinases (SVMP)-induced tissue damage, including the transient activation of tissue proteinases, and underscored for the first time that endothelial glycocalyx proteoglycans and PDGFR were targets of SVMPs in the disruption of microvasculature integrity and generation of hemorrhage.
[Scientific Reports]
Asega, A. F., Menezes, M. C., Trevisan-Silva, D., Cajado-Carvalho, D., Bertholim, L., Oliveira, A. K., Zelanis, A., & Serrano, S. M. T. (2020). Cleavage of proteoglycans, plasma proteins and the platelet-derived growth factor receptor in the hemorrhagic process induced by snake venom metalloproteinases. Scientific Reports, 10(1), 12912. https://doi.org/10.1038/s41598-020-69396-y Cite
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Roseotoxin B Alleviates Cholestatic Liver Fibrosis through Inhibiting PDGF-B/PDGFR-β Pathway in Hepatic Stellate Cells

Roseotoxin B was shown to possess an improving effect on cholestatic liver fibrosis in bile duct–ligated mice, as proved by histochemical and immunohistochemical staining, hepatic biochemical parameters, and TUNEL apoptotic cell detection in tissue sections.
[Cell Death & Disease]
Wang, X., Gao, Y., Li, Y., Huang, Y., Zhu, Y., Lv, W., Wang, R., Gou, L., Cheng, C., Feng, Z., Xie, J., Tian, J., & Yao, R. (2020). Roseotoxin B alleviates cholestatic liver fibrosis through inhibiting PDGF-B/PDGFR-β pathway in hepatic stellate cells. Cell Death & Disease, 11(6), 1–13. https://doi.org/10.1038/s41419-020-2575-0 Cite
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