Tag results:

PDGF

Endothelial Plasticity Drives Aberrant Vascularization and Impedes Cardiac Repair after Myocardial Infarction

[Nature Cardiovascular Research] Investigators characterized vascular aberrancies induced by myocardial infarction (MI) and proposed to target acquired endothelial cell changes to normalize vessels and promote cardiac repair after MI.

The Conditioned Medium from Mesenchymal Stromal Cells Pretreated with Proinflammatory Cytokines Promote Fibroblasts Migration and Activation

[PLoS One] Investigators embedded a scaffold material containing conditioned medium of MSCs (MSC-CM) pretreated with IFN-γ and TNF-α and reconfirmed that cell migration and activation were superior to that in the presence of MSC-CM in vivo.

Valproic Acid Decreases Vascular Smooth Muscle Cell Proliferation via Protein Phosphatase 2A-Mediated p70 S6 Kinase Inhibition

[Biochemical and Biophysical Research Communications] Scientists investigated the molecular mechanism by which valproic acid inhibited rat vascular smooth muscle cell proliferation.

A Vasculature Niche Orchestrates Stromal Cell Phenotype through PDGF Signaling: Importance in Human Fibrotic Disease

[Proceedings of the National Academy of Sciences of the United States of America] Researchers used Dupuytren’s disease, a localized fibrotic condition of the hand, as a model to profile the vasculature niche of human fibrosis at single-cell resolution.

Intramuscular Injection of Sotagliflozin Promotes Neovascularization in Diabetic Mice through Enhancing Skeletal Muscle Cells Paracrine Function

[Acta Pharmacologica Sinica] Researchers investigated whether sotagliflozin, an anti-hyperglycemia SGLT2 inhibitor, exerted therapeutic angiogenesis effects in diabetic HLI in vitro and in vivo.

Characterization of PDGF-BB:PDGFRβ Signaling Pathways in Human Brain Pericytes: Evidence of Disruption in Alzheimer’s Disease

[Communications Biology] The authors tested the effects of platelet-derived growth factor-BB (PDGF-BB) on primary human brain pericytes in vitro to define pathways related to blood-brain barrier function.

Popular