Researchers showed that smooth muscle cell (SMC)-specific knockout of the Pdgfrb gene, which encodes platelet-derived growth factor receptor beta (PDGFRβ), in Apoe−/− mice fed a Western diet for 18 weeks resulted in brachiocephalic artery lesions nearly devoid of SMCs but with no changes in lesion size, remodelling or indices of stability, including the percentage of ACTA2+ fibrous cap cells.
[Nature Metabolism]
Newman, A. A. C., Serbulea, V., Baylis, R. A., Shankman, L. S., Bradley, X., Alencar, G. F., Owsiany, K., Deaton, R. A., Karnewar, S., Shamsuzzaman, S., Salamon, A., Reddy, M. S., Guo, L., Finn, A., Virmani, R., Cherepanova, O. A., & Owens, G. K. (2021). Multiple cell types contribute to the atherosclerotic lesion fibrous cap by PDGFRβ and bioenergetic mechanisms. Nature Metabolism, 3(2), 166–181. https://doi.org/10.1038/s42255-020-00338-8 Cite
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