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PDGF

GSDMB Is Increased in IBD and Regulates Epithelial Restitution/Repair Independent of Pyroptosis

[Cell] The authors reported increased gasdermin B (GSDMB) in inflammatory bowel disease, with single-cell analysis identifying epithelial specificity to inflamed colonocytes/crypt top colonocytes.

Regeneration of Collagen Fibrils at the Papillary Dermis by Reconstructing Basement Membrane at the Dermal–Epidermal Junction

[Scientific Reports] Researchers suggested that reconstructing the basement membrane promoted secretion of platelet-derived growth factor consisting of two B subunits by epidermal keratinocytes, leading to increased collagen expression at the papillary dermis.

PDGF-D−PDGFRβ Signaling Enhances IL-15–Mediated Human Natural Killer Cell Survival

[Proceedings of the National Academy of Sciences of the United States of America] Scientists reported an additional but previously unknown role of PDGF-D, whereby it mediated interleukin-15–induced human NK cell survival but not effector functions via its binding to PDGFRβ but independent of its binding to NKp44.

LDHA Mediated Degradation of Extracellular Matrix Is a Potential Target for the Treatment of Aortic Dissection

[Pharmacological Research] Researchers found that the level of lactate dehydrogenase A (LDHA) was significantly elevated in aortic dissection patients and the mouse model established by BAPN combined with Ang II.

Imatinib Mesylate Inhibits Androgen-Independent PC-3 Cell Viability, Proliferation, Migration, and Tumor Growth by Targeting Platelet-Derived Growth Factor Receptor-α

[Life Sciences] The authors examined the role of platelet-derived growth factor receptors (PDGFRs) in androgen-independent PC-3 cells and found that PDGFRα was upregulated in androgen-independent PC-3 cells compared with normal prostate epithelial cells.

3D Spheroids of Human Placenta-Derived Mesenchymal Stem Cells Attenuate Spinal Cord Injury in Mice

[Cell Death & Disease] The authors found that 3D human placenta-derived MSCs demonstrated a significant increase in secretion of anti-inflammatory factors and trophic factors like VEGF, PDGF, FGF via QPCR and Bio-Plex assays.

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