Tag results:
PDGF
Intestinal Cell News
GSDMB Is Increased in IBD and Regulates Epithelial Restitution/Repair Independent of Pyroptosis
[Cell] The authors reported increased gasdermin B (GSDMB) in inflammatory bowel disease, with single-cell analysis identifying epithelial specificity to inflamed colonocytes/crypt top colonocytes.
Dermal Cell News
Regeneration of Collagen Fibrils at the Papillary Dermis by Reconstructing Basement Membrane at the Dermal–Epidermal Junction
[Scientific Reports] Researchers suggested that reconstructing the basement membrane promoted secretion of platelet-derived growth factor consisting of two B subunits by epidermal keratinocytes, leading to increased collagen expression at the papillary dermis.
Human Immunology News
PDGF-D−PDGFRβ Signaling Enhances IL-15–Mediated Human Natural Killer Cell Survival
[Proceedings of the National Academy of Sciences of the United States of America] Scientists reported an additional but previously unknown role of PDGF-D, whereby it mediated interleukin-15–induced human NK cell survival but not effector functions via its binding to PDGFRβ but independent of its binding to NKp44.
Extracellular Matrix News
LDHA Mediated Degradation of Extracellular Matrix Is a Potential Target for the Treatment of Aortic Dissection
[Pharmacological Research] Researchers found that the level of lactate dehydrogenase A (LDHA) was significantly elevated in aortic dissection patients and the mouse model established by BAPN combined with Ang II.
Prostate Cell News
Imatinib Mesylate Inhibits Androgen-Independent PC-3 Cell Viability, Proliferation, Migration, and Tumor Growth by Targeting Platelet-Derived Growth Factor Receptor-α
[Life Sciences] The authors examined the role of platelet-derived growth factor receptors (PDGFRs) in androgen-independent PC-3 cells and found that PDGFRα was upregulated in androgen-independent PC-3 cells compared with normal prostate epithelial cells.
Mesenchymal Cell News
3D Spheroids of Human Placenta-Derived Mesenchymal Stem Cells Attenuate Spinal Cord Injury in Mice
[Cell Death & Disease] The authors found that 3D human placenta-derived MSCs demonstrated a significant increase in secretion of anti-inflammatory factors and trophic factors like VEGF, PDGF, FGF via QPCR and Bio-Plex assays.