PI3K

[Brain Research Bulletin] Probing the possible mechanisms of neuroprotection revealed that dental pulp stem cells (DPSCs)/DPSCs-conditioned media treatment upregulated an array of hosts’ endogenous neural survival factors expression.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers showed that the phosphatidylserine (PtdSer) lipid transport proteins, ORP5 and ORP8, which are essential for maintaining plasma membrane (PM) PtdSer levels and hence KRAS PM localization, were required for KRAS oncogenesis.

[Journal of Oncology] The authors investigated the role of miR-145-5p in prostate cancer (PCa) and its potential molecular mechanisms and confirmed that miR-145-5p inhibited the growth and metastasis of PCa cells by inhibiting the expression of proto-oncogene WIP1.

[Signal Transduction and Targeted Therapy] The authors suggest that cascading inhibitors of the PI3K/Akt signaling pathway, either alone or in combination with other therapies, are the most effective treatment strategy for cancer.

[Cancer Discovery] Lentiviral barcoding/single cell RNA-sequencing reveal that HER2+ breast cancer cells cycle stochastically through a "pre-drug-tolerant persister" state, characterized by a G0-like expression signature and enriched for diapause and/or senescence genes.

[Frontiers in Cell and Developmental Biology] Scientists found that halofuginone inhibited the proliferation, induced G0/G1 phase arrest, and promoted apoptosis in lung cancer cells in a dose-dependent manner.