PI3K

[Molecular Cancer Research] Scientists address the mechanistic progress on how PRK-like endoplasmic reticulum kinase (PERK) acts as a multifunctional molecule to commit 17β-estradiol to inducing apoptosis in endocrine-resistant breast cancer.

[Scientific Reports] Investigators used peripheral blood and bone marrow samples from patients with acute myeloid leukemia (AML) to analyze the impact of CD157-directed antibodies in AML survival and in response to cytarabine ex vivo.

[Cell Communication and Signaling] A dystrophin-deficient myoblast cell line established from the skeletal muscle of a dystrophic mouse was used as a model. The dfd13 and C2C12 myoblasts were cultured in low mitogen conditions for ten days to induce differentiation.

[Cell Death & Disease] Investigators confirmed that BEZ235 could suppress the proliferation, invasion and colony conformation abilities of intrahepatic cholangiocarcinoma (ICC) cells in vitro but could not effectively inhibit ICC progression in vivo.

[Cell Death Discovery] CircRNA microarray analysis was used to assess the plasma from hepatocellular carcinoma (HCC) patients and healthy controls and to identify circRNAs involved in HCC tumorigenesis.

[Cell Reports] Scientists reported that low FBXO31 mRNA levels were associated with high pre-operative prostate-specific antigen levels and Gleason grade in human prostate cancer.