Tag results:
PI3K
Pancreatic Cell News
IGF-1 Ameliorates Streptozotocin-Induced Pancreatic β Cell Dysfunction and Apoptosis via Activating IRS1/PI3K/Akt/FOXO1 Pathway
[Inflammation Research] Scientists demonstrated the protective role of Insulin-like growth factor 1 (IGF-1) against pancreatic β cell dysfunction and to probe into the underlying mechanisms.
Hepatic Cell News
Context Dependent Isoform Specific PI3K Inhibition Confers Drug Resistance in Hepatocellular Carcinoma Cells
[BMC Cancer] The bioactivities of inhibitors on PTEN adequate Huh7 and deficient Mahlavu cells were investigated with real time cell growth, cell cycle and cell migration assays.
Prostate Cell News
The Marine Factor 3,5-Dihydroxy-4-Methoxybenzyl Alcohol Suppresses Growth, Migration and Invasion and Stimulates Death of Metastatic Human Prostate Cancer Cells: Targeting Diverse Signaling Processes
[Anti-Cancer Drugs] Scientists investigated whether the novel factor 3,5-dihydroxy-4-methoxybenzyl alcohol, suppressed the activity of metastatic human prostate cancer PC-3 or DU-145 cells.
Intestinal Cell News
MiR-323a Regulates ErbB3/EGFR and Blocks Gefitinib Resistance Acquisition in Colorectal Cancer
[Cell Death & Disease] Scientists detected the receptor tyrosine kinase activity in gefitinib-resistant colorectal cancer cells, pan-erb-b2 receptor tyrosine kinase 3 (ErbB3)/EGFR was significantly activated and provided a potential multi-ErbB treatment target.
Pulmonary Cell News
The Glucocorticoid Receptor Associates with RAS Complexes to Inhibit Cell Proliferation and Tumor Growth
[Science Signaling] The authors found that glucocorticoid receptor was present in cytoplasmic KRAS-containing complexes and inhibited the activation of wild-type and oncogenic KRAS in mouse embryonic fibroblasts and human lung cancer A549 cells.
Muscle Cell News
Bioactivity and miRNome Profiling of Native Extracellular Vesicles in Human Induced Pluripotent Stem Cell-Cardiomyocyte Differentiation
[Advanced Science] Scientists isolated extracellular vesicles (EVs) from key stages of the human induced pluripotent stem cell-cardiomyocyte differentiation and maturation, with the aim of identifying a promising cell biofactory for EV production, and pinpointed the genetic signatures of bioactive EVs.