PI3K

[Bioscience Reports] Researchers recently investigated the antitumour effect of digoxin, a well-established drug for treating heart failure, against nonsmall cell lung cancer A549 and H1299 cells.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists identified the cell-surface–expressed A-disintegrin-and-metalloproteinase 10 as an essential regulator of conventional dendritic cell (cDC)1 and cDC2 homeostasis in the splenic marginal zone.

[Acta Pharmacologica Sinica] Scientists investigated whether asiatic acid exerted cardioprotective effects against myocardial infarction by activating glycophagy and mitophagy to improve the energy balance. In vitro cardioprotective effects were examined in neonatal mouse cardiomyocytes subjected to oxygen-glucose deprivation for 12 hours.

[Scientific Reports] Through in vitro experiments, scientists found that genistein reduced IL-17A and TNF-α induced MAPK, NF-κB, and PI3K activation in normal human epidermal keratinocytes.

[Nature Communications] Comparison of Tripartite motif containing protein 24 (TRIM24) in mouse mammary epithelia (Trim24COE) metaplastic carcinosarcoma morphology, TRIM24 protein levels and a derived Trim24COE gene signature revealed strong correlation with human metaplastic breast cancers (MpBC) tumors and MpBC patient-derived xenograft models.

[Bioengineered] Researchers found RECQL4 was upregulated in colon adenocarcinoma (COAD), especially in Oxaliplatin-resistant COAD tissues and cells.