PI3K

[npj Precision Oncology] Researchers provided in-depth investigation of copy number alteration heterogeneity in phenotypically characterized circulating tumor cells at resistance to Anaplastic Lymphoma Kinase (ALK)-tyrosine kinase inhibitors in ALK-positive non-small cell lung cancer.

[npj Precision Oncology] Researchers identified increased fibroblast growth factor receptor 1 (FGFR1) expression and Akt activation across erlotinib, gefitinib, and osimertinib EGFR-tyrosine kinase inhibitor (TKI)-resistant cell line models.

[ACS Biomaterials Science & Engineering] Hydrogel prepared with alginate and the pancreatic extracellular matrix was assessed for the beneficial outcomes on encapsulated insulin-producing cells.

[RNA Biology] Researchers discovered that ZBED3 antisense RNA 1 (ZBED3-AS1) was overexpressed in melanoma cells compared with human epidermal melanocytes.

[Scientific Reports] Researchers found that Stathmin (STMN1) was overexpressed in lung cancer tissues and associated with worse survival rates of lung cancer patients.

[Journal of Cell Science] Human umbilical vein endothelial cells (HUVECs) elongated, activated TAGLN promoter and increased TAGLN transcripts in angiogenesis model. Genetic disruption of TAGLN augmented angiogenic behaviors of HUVECs, as did the disruption of TAGLN2 and TAGLN3 genes.