PI3K

[Cell Death & Disease] Researchers showed that conditional knockout of the demethylase Alkbh5 in bone marrow MSCs strengthened bone mass in mice.

[Nature] Scientists applied an oncogene-associated, multicolor reporter mouse model to the small intestine to show that oncogene-expressing mutant crypts altered the cellular organization of neighbouring wild-type crypts, thereby driving accelerated clonal drift.

[Molecular Therapy-Nucleic Acids] The upregulated gonadotropin-releasing hormone (GnRH) expression in GT1-7 GnRH neuronal cells induced by the 5-HT receptor 1A (HTR1A) antagonist WAY-100635 maleate was observed in vitro.

[Molecular Oncology] By probing a number of kinases downstream of integrin-β1, scientists determined that PI3K inhibition with either a tool compounds or a compound in clinical trials robustly sensitizes quiescent breast tumor cells seeded in organotypic bone marrow cultures to chemotherapy.

[EMBO Molecular Medicine] Researchers searched for a gene signature that discriminate localised pancreatic ductal adenocarcinoma (PDAC) from confirmed metastatic PDAC and devised a preclinical protocol using circulating cell-free DNA (cfDNA) as an early biomarker of micro-metastatic disease to validate the identification of key signalling events.

[Cell Stem Cell] Photobiomodulation therapy was found to drive quiescent hair follicle stem cell activation and alleviate hair follicle atrophy.