PI3K

[Molecular Therapy Oncolytics] MicroRNAs (MiRNAs) that targeted ADP-ribosylation factor 6 (ARF6) were predicted and selected in high metastatic breast cancer cells treated with C–C motif chemokine ligand 18 (CCL18).

[Acta Pharmacologica Sinica] Scientists found that cinobufotalin (CB) decreased cisplatin (DDP) resistance, migration and invasion in lung adenocarcinoma and showed that CB induced ENKUR expression by suppressing PI3K/AKT signaling to downregulate c-Jun, a negative transcription factor of ENKUR.

[Fundamental & Clinical Pharmacology] The changes in gene expression profiles of multidrug resistant prostate cancer cells that were established in response to docetaxel were determined using microarray analysis.

[European Journal of Histochemistry] Researchers showed that the level of miR-19a was significantly higher in clinical CRC tissue samples than in paracancerous tissue samples, and significantly higher in CRC cells lines HT29, SW480, and CaCO2 than in the normal human colon mucosal epithelial cell line NCM460.

[BMC Cardiovascular Disorders] Investigators probed the therapeutic effects of MSC-derived exosomes on myocardial fibrosis after myocardial infarction and possible mechanisms.

[Scientific Reports] The authors investigated the relationship amongst PTEN deletion, L-asparaginase sensitivity and glucose metabolism in T cell acute lymphoblastic leukemia cells.