PI3K

[Journal of Natural Products] An in-house library of 2576 plant extracts was screened on two melanoma cell lines with different oncogenic mutations leading to pathological ERK/AKT activity.

[Cell Death Discovery] Researchers demonstrated that circular RNA PRKCI (circPRKCI), derived from the PRKCI gene, was elevated in breast cancer tissues and cell lines, especially in TNBC.

[Cell Death & Disease] The authors reported that hypoxia-inducible factor 1α (HIF-1α) was upregulated after ATP treatment and mediated the ATP-driven chemoresistance process.

[Cell Death & Disease] Researchers reported that expression of mucin 15 (MUC15) was downregulated in liver tumor-initiating cells, chemoresistance, and recurrent HCC samples.

[Phytotherapy Research] Investigators explored the function of lucidone in tumor cytotoxicity and chemosensitivity through the suppression of receptor for advanced glycation end products-initiated signaling in pancreatic ductal adenocarcinoma cells.

[Oncogenesis] Researchers integrated human studies, genetic mouse modeling, and cellular systems to characterize the regulation and function of glycine N-Methyltransferase in prostate cancer.