PI3K

[Stem Cell Reviews and Reports] Researchers revealed that treatment with the human umbilical cord mesenchymal stromal cells significantly increased the proportion of activated primordial follicles in mouse ovaries both in vitro and in vivo.

[Molecular Cancer therapeutics] Scientists investigated the response of PTEN wild-type prostate cancer cell lines to the dual PI3K/mTOR inhibitor DS-7423 alone or in combination with HER2 inhibitors or mGluR1 inhibitors.

[Molecular Cancer Research] Investigators found that the acidic tumor microenvironment contributed to lipid accumulation in liver cancer by activating the PI3K/AKT signaling pathway and promoting SCD1-PPARα binding.

[Scientific Reports] To find additional hematologic entities with ectopic expression of BCL2 family members, investigators performed expression screening of cell lines applying the LL-100 panel.

[Cellular and Molecular Life Sciences] The authors review the clinical significance of mesenchymal circulating tumor cells (CTCs) in breast cancer together with statistical analysis of previously published data, in which they assess the suitability of a number of methods/markers used for isolation of CTCs with different epithelial-mesenchymal transition phenotypes.

[Cell Death & Disease] Researchers investigated the molecular mechanism underlying galectin-1-mediated chemoresistance in hepatocellular carcinoma cells, particularly the involvement of P-glycoprotein in this effect.