Oncogenic Smurf1 Promotes PTEN Wild-Type Glioblastoma Growth by Mediating PTEN Ubiquitylation

Smurf1 promotes cell growth and colony formation by accelerating cell cycle and aberrant signaling pathways. In addition, the authors showed that Smurf1 ubiquitylates and degrades phosphatase and tensin homolog.
[Oncogene]
Abstract
Bookmark

No account yet? Register

0
Share

Progesterone Receptor Membrane Component 1 Promotes the Growth of Breast Cancers by Altering the Phosphoproteome and Augmenting EGFR/PI3K/AKT Signalling

Investigators demonstrated that progesterone receptor membrane component 1 played a prominent role in regulating the growth of cancer cells by altering the PI3K/AKT/mTOR and EGFR signalling mechanisms in both ER-positive and TNBC cells.
[British Journal of Cancer]
Abstract
Bookmark

No account yet? Register

0
Share

Osteogenic Cocktail Induces Calcifications in Human Breast Cancer Cell Line via Placental Alkaline Phosphatase Expression

The authors found that breast cancer cells acquired alkaline phosphatase enzyme activity via placental alkaline phosphatase expression and suggested that breast calcification formation was closely associated with the PI3K-Akt signaling pathway.
[Scientific Reports]
Full Article
Bookmark

No account yet? Register

0
Share

Activating PIK3CA Mutation Promotes Adipogenesis of Adipose-Derived Stem Cells in Macrodactyly via Up-Regulation of E2F1

PIK3CA (H1047R) Activating Mutation and Enhanced Activity of PI3K/AKT Pathway were Detected in Macrodactylous Adipose-Derived Stem Cells (Mac-ADSCs).
[Cell Death & Disease]
Full Article
Bookmark

No account yet? Register

0
Share

Anlotinib Suppresses Tumor Progression via Blocking the VEGFR2/PI3K/Akt Cascade in Intrahepatic Cholangiocarcinoma

Using in vitro experiments, investigators found that anlotinib had significant effects on proliferation inhibition, migration and invasion restraint, and cell-cycle arrestment in intrahepatic cholangiocarcinoma.
[Cell Death & Disease]
Song, F., Hu, B., Cheng, J.-W., Sun, Y.-F., Zhou, K.-Q., Wang, P.-X., Guo, W., Zhou, J., Fan, J., Chen, Z., & Yang, X.-R. (2020). Anlotinib suppresses tumor progression via blocking the VEGFR2/PI3K/AKT cascade in intrahepatic cholangiocarcinoma. Cell Death & Disease, 11(7), 1–14. https://doi.org/10.1038/s41419-020-02749-7 Cite
Full Article
Bookmark

No account yet? Register

0
Share

SOX2 and p53 Expression Control Converges in PI3K/AKT Signaling with Versatile Implications for Stemness and Cancer

The authors summarize the latest advances in the understanding of PI3K/AKT/SOX2-driven stemness and its intertwined relations to p53-signaling in DNA damage response under conditions of pluripotency, reprogramming, and transformation.
[International Journal of Molecular Sciences]
Full Article
Bookmark

No account yet? Register

0
Share

PRDM15 Is a Key Regulator of Metabolism Critical to Sustain B-Cell Lymphomagenesis

Investigators demonstrated that while PRDM15 was largely dispensable for mouse adult somatic cell homeostasis in vivo, it played a critical role in B-cell lymphomagenesis.
[Nature Communications]
Mzoughi, S., Fong, J. Y., Papadopoli, D., Koh, C. M., Hulea, L., Pigini, P., … Guccione, E. (2020). PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis. Nature Communications, 11(1), 3520. https://doi.org/10.1038/s41467-020-17064-0 Cite
Full Article
Bookmark

No account yet? Register

0
Share

A Novel 4-Aminoquinazoline Derivative, DHW-208, Suppresses the Growth of Human Breast Cancer Cells by Targeting the PI3K/AKT/mTOR Pathway

Researchers report for the first time that DHW-208 suppressed the growth of human breast cancer cells by inhibiting the PI3K/AKT/mTOR-signaling pathway both in vivo and in vitro.
[Cell Death & Disease]
Full Article
Bookmark

No account yet? Register

0
Share

YES1 Amplification Confers Trastuzumab–Emtansine (T-DM1) Resistance in HER2-Positive Cancer

The authors revealed that YES1 amplification conferred resistance to HER2-targeted drugs.
[British Journal of Cancer]
Abstract
Bookmark

No account yet? Register

0
Share

GABA Stimulates β-Cell Proliferation through the mTORC1/p70S6K Pathway, an Effect Amplified by Ly49, a Novel GABAA-R Positive Allosteric Modulator

Researchers demonstrated that GABA stimulates β‐cell proliferation via the PI3K/mTORC1/p70S6K pathway in both mouse and human islets.
[Diabetes Obesity & Metabolism]
Untereiner, A., Xu, J., Bhattacharjee, A., Cabrera, O., Hu, C., Dai, F. F., & Wheeler, M. B. (2020). GABA stimulates β-cell proliferation through the mTORC1/p70S6K pathway, an effect amplified by Ly49, a novel GABAA-R positive allosteric modulator. Diabetes, Obesity and Metabolism, n/a(n/a). https://doi.org/10.1111/dom.14118 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Signaling Inhibitors Accelerate the Conversion of Mouse iPS Cells into Cancer Stem Cells in the Tumor Microenvironment

Inhibition of Erk1/2, tyrosine kinase, and/or GSK-3β was implied to be involved in the enhancement of the PI3K-AKT signaling pathway in the undifferentiated cells, resulting in the sustained stemness, and subsequent conversion of mouse iPSCs into cancer stem cells in the tumor microenvironment.
[Scientific Reports]
Du, J., Xu, Y., Sasada, S., Oo, A. K. K., Hassan, G., Mahmud, H., Khayrani, A. C., Alam, M. J., Kumon, K., Uesaki, R., Afify, S. M., Mansour, H. M., Nair, N., Zahra, M. H., Seno, A., Okada, N., Chen, L., Yan, T., & Seno, M. (2020). Signaling Inhibitors Accelerate the Conversion of mouse iPS Cells into Cancer Stem Cells in the Tumor Microenvironment. Scientific Reports, 10(1), 9955. https://doi.org/10.1038/s41598-020-66471-2 Cite
Full Article
Bookmark

No account yet? Register

0
Share
Share