PI3K

[Cancer Research] BRAF inhibitor induced BRAF-CRAF heterodimerization and subsequent activation of ERK signaling in cancer-associated fibroblasts, leading to inactivation of the β-catenin destruction complex.

[Biomedicine & Pharmacotherapy] Decursin exhibited no cytotoxicity and significantly reduced intracellular tyrosinase activity and melanin content in B16F10 melanoma cells.

[Cancer & Metabolism] As cholesterol is a key substrate for de novo steroidogenesis in prostate cells, researchers hypothesized that castrate-resistant/advanced prostate cancer cell growth was influenced by the availability of extracellular, low-density lipoprotein (LDL)-derived, cholesterol, which was coupled to intracellular cholesteryl ester homeostasis.

[Oncogene] BEST4 is a member of the bestrophin protein family that plays a critical role in human intestinal epithelial cells. Scientists investigated the role and clinical significance of BEST4 in CRC.

[Virchows Archiv] The authors cover the evolution and latest updates of the CAP/ASCO guidelines relevant to these two important biomarkers in breast cancer.

[FEBS Journal] Investigators observed that the increase of Sox9 significantly promoted hepatocellular carcinoma cell growth and invasion in cell cultures, whereas knockdown of Sox9 showed the opposite effects, suggesting that Sox9 may regulate the proliferation and invasion of hepatoma cells in an autocrine manner.