PKM2

[Gut] Scientists elucidated the nature, regulation and functional relevance of PD-L1+ host cells in HCC.

[Molecular Therapy Oncolytics] Scientists explored the biological function of circSHKBP1 in NSCLC. CircSHKBP1 was found to be upregulated in NSCLC tissues and cell lines and was enriched in exosomes derived from NSCLC cells.

[Clinical Cancer Research] DNA-dependent kinase catalytic subunit (DNA-PK) regulation of metabolism was interrogated using pharmacological and genetic perturbation using in vitro cell models, in vivo xenografts, and ex vivo in patient-derived explants

[Molecular Therapy-Nucleic Acids] The authors explored the expression, role and mechanism of DNA damage regulated autophagy modulator 1 (DRAM1) in alcohol-related liver disease and revealed that ethanol-induced DRAM1 of hepatic cells could increase the pyruvate kinase M2 (PKM2)-enriched extracellular vesicles.

[Cell Reports] From a genome-wide functional screen, scientists identified pyruvate kinase M2 as a gamma-secretase activator that was highly expressed in the brains of both patients and murine models with Alzheimer’s disease.

[Oncogene] Scientists found that the 18fluoro-deoxyglucose positron emission tomography/computed tomography-based markers were positively associated with the expression of programmed cell death ligand 1, pyruvate kinase M2, both of which indicate poor prognosis in patients with pancreatic ductal adenocarcinoma.