Tag Archives: PTEN

Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Alleviate Lung Injury in Rat Model of Bronchopulmonary Dysplasia by Affecting Cell Survival and Angiogenesis

Researchers found that human umbilical cord MSCs-derived small extracellular vesicles were successfully absorbed by lung tissue after intratracheal administration, and remained in the lungs for at least 72 hours.
[Stem Cells and Development]
You, J., Zhou, O., Liu, J., Zou, W., Zhang, L., Tian, D., Dai, J., Luo, Z., Liu, E., Fu, Z., & Zou, L. (2020). Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Alleviate Lung Injury in Rat Model of Bronchopulmonary Dysplasia by Affecting Cell Survival and Angiogenesis. Stem Cells and Development. https://doi.org/10.1089/scd.2020.0156 Cite
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SET8 Suppression Mediates High Glucose-Induced Vascular Endothelial Inflammation via the Upregulation of PTEN

The authors’ in vitro study indicated that high glucose increased monocyte/endothelial adhesion, endothelial adhesion molecule expression and p65 phosphorylation in human umbilical vein endothelial cells.
[Experimental and Molecular Medicine]
Shen, X., Chen, X., Wang, J., Liu, J., Wang, Z., Hua, Q., Wu, Q., Su, Y., He, H., Hu, Y., Meng, Z., Xiong, W., & Zhu, M. (2020). SET8 suppression mediates high glucose-induced vascular endothelial inflammation via the upregulation of PTEN. Experimental & Molecular Medicine, 1–15. https://doi.org/10.1038/s12276-020-00509-3 Cite
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Estrogen Receptor β Regulates AKT Activity through Up-Regulation of INPP4B and Inhibits Migration of Prostate Cancer Cell Line PC-3

Investigators found that in prostate cancer (PCa), samples from men treated with androgen deprivation therapy, ERβ, and inositol-polyphosphate 4-phosphatase type II (INPP4B) expression were maintained in some samples. To investigate the role of ERβ1 in regulation of INPPB, they engineered the highly metastatic PCa cell line, PC3, to express ERβ1.
[Proceedings of the National Academy of Sciences of the United States of America]
Chaurasiya, S., Wu, W., Strom, A. M., Warner, M., & Gustafsson, J.-Å. (2020). Estrogen receptor β regulates AKT activity through up-regulation of INPP4B and inhibits migration of prostate cancer cell line PC-3. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2007160117 Cite
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Patient-Derived Organoids and Orthotopic Xenografts of Primary and Recurrent Gliomas Represent Relevant Patient Avatars for Precision Oncology

Investigators report the establishment a large cohort of unique organoids and patient-derived orthotopic xenografts (PDOX) of various glioma subtypes, including gliomas with mutations in IDH1, and paired longitudinal PDOX from primary and recurrent tumors of the same patient.
[Acta Neuropathologica]
Golebiewska, A., Hau, A.-C., Oudin, A., Stieber, D., Yabo, Y. A., Baus, V., Barthelemy, V., Klein, E., Bougnaud, S., Keunen, O., Wantz, M., Michelucci, A., Neirinckx, V., Muller, A., Kaoma, T., Nazarov, P. V., Azuaje, F., De Falco, A., Flies, B., … Niclou, S. P. (2020). Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology. Acta Neuropathologica. https://doi.org/10.1007/s00401-020-02226-7 Cite
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Exploiting Chromosomal Instability of PTEN-Deficient Triple-Negative Breast Cancer Cell Lines for the Sensitization against PARP1 Inhibition in a Replication-Dependent Manner

Scientists recognized the tumor suppressor gene Phosphatase and Tensin homolog (PTEN) as a potential gene causing CIN in TNBC and showed that TNBC with low expression levels of PTEN can be sensitized for the treatment with poly-(ADP-ribose)-polymerase 1 (PARP1) inhibitors, independent of Breast Cancer (BRCA) mutations or a BRCA-like phenotype.
[Cancers]
Rieckhoff, J., Meyer, F., Classen, S., Zielinski, A., Riepen, B., Wikman, H., Petersen, C., Rothkamm, K., Borgmann, K., & Parplys, A. C. (2020). Exploiting Chromosomal Instability of PTEN-Deficient Triple-Negative Breast Cancer Cell Lines for the Sensitization against PARP1 Inhibition in a Replication-Dependent Manner. Cancers, 12(10), 2809. https://doi.org/10.3390/cancers12102809 Cite
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Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas

Researchers showed that PTEN-deficient glioblastomas largely depended on p110α for proliferation and p110β for migration.
[Cell Reports]
Xie, S., Ni, J., McFaline-Figueroa, J. R., Wang, Y., Bronson, R. T., Ligon, K. L., Wen, P. Y., Roberts, T. M., & Zhao, J. J. (2020). Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas. Cell Reports, 32(13). https://doi.org/10.1016/j.celrep.2020.108196 Cite
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Role of Androgen Receptor Splice Variant-7 (AR-V7) in Prostate Cancer Resistance to 2nd-Generation Androgen Receptor Signaling Inhibitors

The role of truncated androgen receptor splice variant-7 (AR-V7) in prostate cancer biology is an unresolved question.The correlation between resistance to AR signaling inhibitors and genetic chances and expression of full length AR vs. AR-V7 were evaluated in a series of independent patient-derived xenografts.
[Oncogene]
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Introduction of hsa-MiR-512-3p as a New Regulator of HER2 Signaling Pathway in Breast Cancer

Researchers found that miR-512-3p acted as a cell-type-specific tumor suppressor, through targeting HER2, HER3, PIK3R2, and AKT1 transcripts.
[Breast Cancer Research and Treatment]
Mohamadzade, Z., Mahjoubi, F., & Soltani, B. M. (2020). Introduction of hsa-miR-512-3p as a new regulator of HER2 signaling pathway in breast cancer. Breast Cancer Research and Treatment. https://doi.org/10.1007/s10549-020-05937-3 Cite
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LncRNA BCYRN1 Inhibits Glioma Tumorigenesis by Competitively Binding with miR-619-5p to Regulate CUEDC2 Expression and the PTEN/AKT/p21 Pathway

Three fresh tumor tissues from glioma patients and three normal brain tissues from craniocerebral trauma patients were prepared for high-throughput RNA sequencing.
[Oncogene]
Mu, M., Niu, W., Zhang, X., Hu, S., & Niu, C. (2020). LncRNA BCYRN1 inhibits glioma tumorigenesis by competitively binding with miR-619-5p to regulate CUEDC2 expression and the PTEN/AKT/p21 pathway. Oncogene, 1–14. https://doi.org/10.1038/s41388-020-01466-x Cite
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PTEN Status Determines Chemosensitivity to Proteasome Inhibition in Cholangiocarcinoma

Scientists determined that phosphate and tensin homology deleted on chromosome ten (PTEN) deficiency promoted protein synthesis and proteasome subunit expression and proteolytic activity, creating a dependency on the proteasome for cancer cell growth and survival.
[Science Translational Medicine]
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IMP3 Accelerates the Progression of Prostate Cancer through Inhibiting PTEN Expression in a SMURF1-Dependent Way

Insulin-like growth factor 2 messenger RNA binding protein 3 expression level was significantly increased in prostate cancer tissues and cell lines as compared with the paracancerous normal tissues and cells.
[Journal of Experimental & Clinical Cancer Research]
Zhang, X., Wang, D., Liu, B., Jin, X., Wang, X., Pan, J., Tu, W., & Shao, Y. (2020). IMP3 accelerates the progression of prostate cancer through inhibiting PTEN expression in a SMURF1-dependent way. Journal of Experimental & Clinical Cancer Research, 39(1), 190. https://doi.org/10.1186/s13046-020-01657-0 Cite
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