Min6 cells were induced by 5 mg/dl UA and the cell proliferation, apoptosis, and insulin release were evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, flow cytometry and glucose-stimulated insulin secretion, respectively.
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Researchers employed lineage-tracing to demonstrate the tumorigenicity potential of the Pten-, SOX9+ cells. They showed that these cells were capable of giving rise to mixed-lineage tumors that manifested features of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (CCA).
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Chen, J., Debebe, A., Zeng, N., Kopp, J., He, L., Sander, M., & Stiles, B. L. (2021). Transformation of SOX9+ cells by Pten deletion synergizes with steatotic liver injury to drive development of hepatocellular and cholangiocarcinoma. Scientific Reports, 11(1), 11823. https://doi.org/10.1038/s41598-021-90958-1 Cite
Investigators generated and analyzed knock-in mice expressing a mutant form of PTEN that could not be phosphorylated by ataxia telangiectasia mutated (ATM), which accelerated tumorigenesis in a model of HER2-positive breast cancer.
[Cell Death & Differentiation]
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Scientists clarified the role of KLHL38 in non-small cell lung cancer (NSCLC). KLHL38 expression was evaluated in tumor and adjacent normal tissues from 241 patients with NSCLC using immunohistochemistry and real-time PCR, and its association with clinicopathological parameters was analyzed.
[Cell Death & Disease]
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Investigators studied the effect of syndecan-1 siRNA depletion and hyaluronic acid treatment on hallmark processes of cancer in breast cancer cell lines of different levels of aggressiveness.
[International Journal of Molecular Sciences]
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Oral administration of an antibiotic mixture in prostate cancer (PCa)-bearing mice fed a high-fat diet containing a large proportion of lard drastically altered the composition of the gut microbiota including Rikenellaceae and Clostridiales, inhibited PCa cell proliferation, and reduced prostate Igf1 expression and circulating IGF-1 levels.
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Investigators studied the interaction between Notch receptors (Notch1-4) and PTEN, and demonstrated that Notch3 inhibited breast cancer proliferation and suppressed tumorigenesis by transactivating PTEN expression.
[Cell Death & Disease]
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Researchers measured a multidimensional migration phenotype for genetically defined human breast epithelial cell lines that ranged in their in vivo behavior from non-tumorigenic to aggressively metastatic.
Scientists provided evidence that the Activating Molecule in Beclin-1-Regulated Autophagy (Ambra1) contributed to melanoma development.
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Di Leo, L., Bodemeyer, V., Bosisio, F. M., Claps, G., Carretta, M., Rizza, S., Faienza, F., Frias, A., Khan, S., Bordi, M., Pacheco, M. P., Di Martino, J., Bravo-Cordero, J. J., Daniel, C. J., Sears, R. C., Donia, M., Madsen, D. H., Guldberg, P., Filomeni, G., … Cecconi, F. (2021). Loss of Ambra1 promotes melanoma growth and invasion. Nature Communications, 12(1), 2550. https://doi.org/10.1038/s41467-021-22772-2 Cite
Investigators elucidated the mechanism of sepsis-induced myocardial injury and examined the value of human umbilical cord mesenchymal stem cells (huMSCs) for protecting cardiac function in sepsis.
[Stem Cell Research & Therapy]
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Zhou, Q., Xie, M., Zhu, J., Yi, Q., Tan, B., Li, Y., Ye, L., Zhang, X., Zhang, Y., Tian, J., & Xu, H. (2021). PINK1 contained in huMSC-derived exosomes prevents cardiomyocyte mitochondrial calcium overload in sepsis via recovery of mitochondrial Ca2+ efflux. Stem Cell Research & Therapy, 12(1), 269. https://doi.org/10.1186/s13287-021-02325-6 Cite
Researchers investigated the effects of extracellular vehicles secreted by human umbilical cord mesenchymal stem cells on angiogenesis under high glucose conditions in vivo and in vitro and to explore the underlying mechanisms.
[Stem Cell Reviews and Reports]
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Wei, Q., Wang, Y., Ma, K., Li, Q., Li, B., Hu, W., Fu, X., & Zhang, C. (2021). Extracellular Vesicles from Human Umbilical Cord Mesenchymal Stem Cells Facilitate Diabetic Wound Healing Through MiR-17-5p-mediated Enhancement of Angiogenesis. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-021-10176-0 Cite