Targeted Next-Generation Sequencing Reveals Heterogenous Genomic Features in Viscerally-Metastatic Prostate Cancer

Through genomic profiling of prostate cancer (PCa) across various metastatic sites, scientists identified an extremely low frequency of androgen receptor alterations in pulmonary metastasis without liver involvement PCa, high prevalence of DNA damage response pathway deficiency in hepatic metastasis PCa and high PTEN alteration rates in viscerally-metastatic PCa.
[Journal of Urology]
Gong Yiming, Fan Liancheng, Fei Xiaochen, Zhu Yinjie, Du Xinxing, He Yuman, Pan Jiahua, Dong Baijun, & Xue Wei. (n.d.). Targeted Next-Generation Sequencing Reveals Heterogenous Genomic Features in Viscerally-Metastatic Prostate Cancer. Journal of Urology, 0(0), 10.1097/JU.0000000000001731. https://doi.org/10.1097/JU.0000000000001731 Cite
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Mutation-Specific Non-Canonical Pathway of PTEN as a Distinct Therapeutic Target for Glioblastoma

Researchers established a library of cancer cell lines that overexpressed mutant proteins using the U87MG and patient-derived cell models lacking functional PTEN.
[Cell Death & Disease]
Choi, S. W., Lee, Y., Shin, K., Koo, H., Kim, D., Sa, J. K., Cho, H. J., Shin, H., Lee, S. J., Kim, H., Chung, S., Shin, J., Lee, C., & Nam, D.-H. (2021). Mutation-specific non-canonical pathway of PTEN as a distinct therapeutic target for glioblastoma. Cell Death & Disease, 12(4), 1–15. https://doi.org/10.1038/s41419-021-03657-0 Cite
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Silencing PTEN in the Fallopian Tube Promotes Enrichment of Cancer Stem Cell-Like Function through Loss of PAX2

Loss of PTEN in fallopian tube epithelium led to the enrichment of CSC markers such as LGR5, WNT4, ALDH1, CD44.
[Cell Death & Disease]
Russo, A., Colina, J. A., Moy, J., Baligod, S., Czarnecki, A. A., Varughese, P., Lantvit, D. D., Dean, M. J., & Burdette, J. E. (2021). Silencing PTEN in the fallopian tube promotes enrichment of cancer stem cell-like function through loss of PAX2. Cell Death & Disease, 12(4), 1–14. https://doi.org/10.1038/s41419-021-03663-2 Cite
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PRDX1 Activates Autophagy via the PTEN-AKT Signaling Pathway to Protect against Cisplatin-Induced Spiral Ganglion Neuron Damage

Macroautophagy/autophagy plays a critical role in spiral ganglion neurons (SGNs) development, but the effect of autophagy on cisplatin-induced SGN injury is unclear. Scientists found that autophagic flux was activated in SGNs after cisplatin damage.
[Autophagy]
Liu, W., Xu, L., Wang, X., Zhang, D., Sun, G., Wang, M., Wang, M., Han, Y., Chai, R., & Wang, H. (2021). PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage. Autophagy, 0(ja), null. https://doi.org/10.1080/15548627.2021.1905466 Cite
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CREG1 Improves the Capacity of the Skeletal Muscle Response to Exercise Endurance via Modulation of Mitophagy

Scientists suggested that CREG1 deficiency accelerated the induction of mitophagy in the skeletal muscle. Mechanistically, gain-and loss-of-function mutations of Creg1 altered mitochondrial morphology and function, impairing mitophagy in C2C12 cells.
[Autophagy]
Song, H., Tian, X., Liu, D., Liu, M., Liu, Y., Liu, J., Mei, Z., Yan, C., & Han, Y. (2021). CREG1 improves the capacity of the skeletal muscle response to exercise endurance via modulation of mitophagy. Autophagy, 0(ja), null. https://doi.org/10.1080/15548627.2021.1904488 Cite
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Inhibition of miR‐188‐5p Alleviates Hepatic Fibrosis by Significantly Reducing the Activation and Proliferation of HSCs through PTEN/PI3K/AKT Pathway

Mimicking the miR‐188‐5p resulted in the up‐regulation of hepatic stellate cell (HSC) activation and proliferation by directly targeting the phosphatase and tensin homolog (PTEN). Inhibition of miR‐188‐5p reduced the activation and proliferation markers of HSCs through PTEN/AKT pathway.
[Journal of Cellular and Molecular Medicine]
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NOTCH and EZH2 Collaborate to Repress PTEN Expression in Breast Cancer

When comparing breast tumors to adjacent normal ducts, PTEN expression was decreased and the PRC2-associated methyltransferase EZH2 was increased.
[Communications Biology]
Pappas, K., Martin, T. C., Wolfe, A. L., Nguyen, C. B., Su, T., Jin, J., Hibshoosh, H., & Parsons, R. (2021). NOTCH and EZH2 collaborate to repress PTEN expression in breast cancer. Communications Biology, 4(1), 1–13. https://doi.org/10.1038/s42003-021-01825-8 Cite
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In Vivo CRISPR Inactivation of Fos Promotes Prostate Cancer Progression by Altering the Associated AP-1 Subunit Jun

Whereas both JUN and FOS have been implicated in prostate cancer, the authors provided evidence that FOS acts as a tumor suppressor during prostate cancer progression and invasion.
[Oncogene]
Riedel, M., Berthelsen, M. F., Cai, H., Haldrup, J., Borre, M., Paludan, S. R., Hager, H., Vendelbo, M. H., Wagner, E. F., Bakiri, L., & Thomsen, M. K. (2021). In vivo CRISPR inactivation of Fos promotes prostate cancer progression by altering the associated AP-1 subunit Jun. Oncogene, 1–11. https://doi.org/10.1038/s41388-021-01724-6 Cite
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Hepatic HuR Protects against the Pathogenesis of Non-alcoholic Fatty Liver Disease by Targeting Pten

Researchers investigated the level of human antigen R in the liver of mice fed a normal chow diet and a high-fat diet.
[Cell Death & Disease]
Tian, M., Wang, J., Liu, S., Li, X., Li, J., Yang, J., Zhang, C., & Zhang, W. (2021). Hepatic HuR protects against the pathogenesis of non-alcoholic fatty liver disease by targeting PTEN. Cell Death & Disease, 12(3), 1–12. https://doi.org/10.1038/s41419-021-03514-0 Cite
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LINC01089 Functions as a ceRNA for miR-152-3p to Inhibit Non‐Small Lung Cancer Progression through Regulating PTEN

Down-regulation of LINC01089 promoted the progression of NSCLC through regulating miR-152-3p/PTEN axis.
[Cancer Cell International]
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Mechanisms of Stearoyl CoA Desaturase Inhibitor Sensitivity and Acquired Resistance in Cancer

Researchers report the unexpected finding that median expression of stearoyl CoA desaturase is low in glioblastoma relative to normal brain due to hypermethylation and unintentional monoallelic co-deletion with phosphatase and tensin homolog in a subset of patients.
[Science Advances]
Oatman, N., Dasgupta, N., Arora, P., Choi, K., Gawali, M. V., Gupta, N., Parameswaran, S., Salomone, J., Reisz, J. A., Lawler, S., Furnari, F., Brennan, C., Wu, J., Sallans, L., Gudelsky, G., Desai, P., Gebelein, B., Weirauch, M. T., D’Alessandro, A., … Dasgupta, B. (2021). Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer. Science Advances, 7(7), eabd7459. https://doi.org/10.1126/sciadv.abd7459 Cite
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