Tag Archives: PTEN

Abnormal Expression of microRNA-296-3p in Type 2 Diabetes Patients and its Role in Pancreatic β-Cells Function by Targeting Tensin Homolog Deleted on Chromosome Ten

Min6 cells were induced by 5 mg/dl UA and the cell proliferation, apoptosis, and insulin release were evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, flow cytometry and glucose-stimulated insulin secretion, respectively.
[Biochemical Genetics]
Cheng, M., Guo, Y., Zhong, W., Chen, X., & Guo, G. (2021). Abnormal Expression of microRNA-296-3p in Type 2 Diabetes Patients and its Role in Pancreatic β-Cells Function by Targeting Tensin Homolog Deleted on Chromosome Ten. Biochemical Genetics. https://doi.org/10.1007/s10528-021-10083-6 Cite
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Transformation of SOX9+ Cells by Pten Deletion Synergizes with Steatotic Liver Injury to Drive Development of Hepatocellular and Cholangiocarcinoma

Researchers employed lineage-tracing to demonstrate the tumorigenicity potential of the Pten-, SOX9+ cells. They showed that these cells were capable of giving rise to mixed-lineage tumors that manifested features of both hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (CCA).
[Scientific Reports]
Chen, J., Debebe, A., Zeng, N., Kopp, J., He, L., Sander, M., & Stiles, B. L. (2021). Transformation of SOX9+ cells by Pten deletion synergizes with steatotic liver injury to drive development of hepatocellular and cholangiocarcinoma. Scientific Reports, 11(1), 11823. https://doi.org/10.1038/s41598-021-90958-1 Cite
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The PTEN and ATM Axis Controls the G1/S Cell Cycle Checkpoint and Tumorigenesis in HER2-Positive Breast Cancer

Investigators generated and analyzed knock-in mice expressing a mutant form of PTEN that could not be phosphorylated by ataxia telangiectasia mutated (ATM), which accelerated tumorigenesis in a model of HER2-positive breast cancer.
[Cell Death & Differentiation]
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KLHL38 Involvement in Non-Small Cell Lung Cancer Progression via Activation of the Akt Signaling Pathway

Scientists clarified the role of KLHL38 in non-small cell lung cancer (NSCLC). KLHL38 expression was evaluated in tumor and adjacent normal tissues from 241 patients with NSCLC using immunohistochemistry and real-time PCR, and its association with clinicopathological parameters was analyzed.
[Cell Death & Disease]
Xu, Y., Wang, C., Jiang, X., Zhang, Y., Su, H., Jiang, J., Ren, H., & Qiu, X. (2021). KLHL38 involvement in non-small cell lung cancer progression via activation of the Akt signaling pathway. Cell Death & Disease, 12(6), 1–14. https://doi.org/10.1038/s41419-021-03835-0 Cite
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Syndecan-1 Depletion Has a Differential Impact on Hyaluronic Acid Metabolism and Tumor Cell Behavior in Luminal and Triple-Negative Breast Cancer Cells

Investigators studied the effect of syndecan-1 siRNA depletion and hyaluronic acid treatment on hallmark processes of cancer in breast cancer cell lines of different levels of aggressiveness.
[International Journal of Molecular Sciences]
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Gut Microbiota-Derived Short-Chain Fatty Acids Promote Prostate Cancer Growth via IGF-1 Signaling

Oral administration of an antibiotic mixture in prostate cancer (PCa)-bearing mice fed a high-fat diet containing a large proportion of lard drastically altered the composition of the gut microbiota including Rikenellaceae and Clostridiales, inhibited PCa cell proliferation, and reduced prostate Igf1 expression and circulating IGF-1 levels.
[Cancer Research]
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Notch3 Inhibits Cell Proliferation and Tumorigenesis and Predicts Better Prognosis in Breast Cancer through Transactivating PTEN

Investigators studied the interaction between Notch receptors (Notch1-4) and PTEN, and demonstrated that Notch3 inhibited breast cancer proliferation and suppressed tumorigenesis by transactivating PTEN expression.
[Cell Death & Disease]
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Distinct Roles of Tumor Associated Mutations in Collective Cell Migration

Researchers measured a multidimensional migration phenotype for genetically defined human breast epithelial cell lines that ranged in their in vivo behavior from non-tumorigenic to aggressively metastatic.
[Scientific Reports]
Lee, R. M., Vitolo, M. I., Losert, W., & Martin, S. S. (2021). Distinct roles of tumor associated mutations in collective cell migration. Scientific Reports, 11(1), 10291. https://doi.org/10.1038/s41598-021-89130-6 Cite
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Loss of Ambra1 Promotes Melanoma Growth and Invasion

Scientists provided evidence that the Activating Molecule in Beclin-1-Regulated Autophagy (Ambra1) contributed to melanoma development.
[Nature Communications]
Di Leo, L., Bodemeyer, V., Bosisio, F. M., Claps, G., Carretta, M., Rizza, S., Faienza, F., Frias, A., Khan, S., Bordi, M., Pacheco, M. P., Di Martino, J., Bravo-Cordero, J. J., Daniel, C. J., Sears, R. C., Donia, M., Madsen, D. H., Guldberg, P., Filomeni, G., … Cecconi, F. (2021). Loss of Ambra1 promotes melanoma growth and invasion. Nature Communications, 12(1), 2550. https://doi.org/10.1038/s41467-021-22772-2 Cite
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PINK1 contained in huMSC-derived exosomes prevents cardiomyocyte mitochondrial calcium overload in sepsis via recovery of mitochondrial Ca2+ efflux

Investigators elucidated the mechanism of sepsis-induced myocardial injury and examined the value of human umbilical cord mesenchymal stem cells (huMSCs) for protecting cardiac function in sepsis.
[Stem Cell Research & Therapy]
Zhou, Q., Xie, M., Zhu, J., Yi, Q., Tan, B., Li, Y., Ye, L., Zhang, X., Zhang, Y., Tian, J., & Xu, H. (2021). PINK1 contained in huMSC-derived exosomes prevents cardiomyocyte mitochondrial calcium overload in sepsis via recovery of mitochondrial Ca2+ efflux. Stem Cell Research & Therapy, 12(1), 269. https://doi.org/10.1186/s13287-021-02325-6 Cite
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Extracellular Vesicles from Human Umbilical Cord Mesenchymal Stem Cells Facilitate Diabetic Wound Healing through MiR-17-5p-mediated Enhancement of Angiogenesis

Researchers investigated the effects of extracellular vehicles secreted by human umbilical cord mesenchymal stem cells on angiogenesis under high glucose conditions in vivo and in vitro and to explore the underlying mechanisms.
[Stem Cell Reviews and Reports]
Wei, Q., Wang, Y., Ma, K., Li, Q., Li, B., Hu, W., Fu, X., & Zhang, C. (2021). Extracellular Vesicles from Human Umbilical Cord Mesenchymal Stem Cells Facilitate Diabetic Wound Healing Through MiR-17-5p-mediated Enhancement of Angiogenesis. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-021-10176-0 Cite
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