Through genomic profiling of prostate cancer (PCa) across various metastatic sites, scientists identified an extremely low frequency of androgen receptor alterations in pulmonary metastasis without liver involvement PCa, high prevalence of DNA damage response pathway deficiency in hepatic metastasis PCa and high PTEN alteration rates in viscerally-metastatic PCa.
[Journal of Urology]
Gong Yiming, Fan Liancheng, Fei Xiaochen, Zhu Yinjie, Du Xinxing, He Yuman, Pan Jiahua, Dong Baijun, & Xue Wei. (n.d.). Targeted Next-Generation Sequencing Reveals Heterogenous Genomic Features in Viscerally-Metastatic Prostate Cancer. Journal of Urology, 0(0), 10.1097/JU.0000000000001731. https://doi.org/10.1097/JU.0000000000001731 Cite
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