Therapeutic Efficacy of FASN Inhibition in Preclinical Models of HCC

The therapeutic efficacy and the molecular pathways targeted by TVB3664, either alone or with tyrosine kinase inhibitors or the checkpoint inhibitor anti-PD-L1 antibody, were assessed in human HCC cell lines and multiple oncogene-driven HCC mouse models.
[Hepatology]
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HER2 Mediates PSMA/mGluR1-Driven Resistance to the DS-7423 Dual PI3K/mTOR Inhibitor in PTEN Wild-Type Prostate Cancer Models

Scientists investigated the response of PTEN wild-type prostate cancer cell lines to the dual PI3K/mTOR inhibitor DS-7423 alone or in combination with HER2 inhibitors or mGluR1 inhibitors.
[Molecular Cancer therapeutics]
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Extracellular Vesicles from Adipose-Derived Stem Cells Promote Microglia M2 Polarization and Neurological Recovery in a Mouse Model of Transient Middle Cerebral Artery Occlusion

The authors explored the contribution of miRNAs in adipose-derived stem cell-extracellular vesicles to the treatment of cerebral ischemia.
[Current Stem Cell Research & Therapy]
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Disruption of Hematopoiesis Attenuates the Osteogenic Differentiation Capacity of Bone Marrow Stromal Cells

The authors investigated the effect of hematopoietic cells on MSCs using various methods, including flow cytometry, adipogenic and osteogenic differentiation analysis, quantitative PCR, western bloting, and microCT analysis.
[Stem Cell Research & Therapy]
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Traf3 Inactivation Promotes the Development of Intrahepatic Cholangiocarcinoma via NIK-Mediated Hepatocyte Transdifferentiation

The authors performed a Sleeping Beauty transposon-based in vivo insertional mutagenesis screen in liver-specific Pten-deficient mice and identified tumor necrosis factor receptor-related factor 3 (Traf3) as the most significantly mutated gene in murine intrahepatic cholangiocarcinoma in a loss-of-function manner.
[Hepatology]
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Overcoming Resistance to Immune Checkpoint Therapy in PTEN-Null Prostate Cancer by Intermittent Anti-PI3Kα/β/δ Treatment

Scientists found that intermittent but not daily dosing of a PI3Kα/β/δ inhibitor, BAY1082439, on Pten-null prostate cancer models could overcome immune checkpoint therapy resistance and unleash CD8+ T cell-dependent anti-tumor immunity in vivo.
[Nature Communications]
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MAPK4 Promotes Triple Negative Breast Cancer Growth and Reduces Tumor Sensitivity to PI3K Blockade

Researchers demonstrated that a large subset of TNBC expressed significant levels of MAPK4, and this expression was critical for driving AKT activation independent of PI3K and promoting TNBC cell and xenograft growth.
[Nature Communications]
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Accumulation of APP-CTF Induces Mitophagy Dysfunction in the iNSCs Model of Alzheimer’s Disease

Scientists demonstrated the effects of amyloid precursor protein-derived C-terminal fragments (APP-CTFs)-related pathology using induced neural stem cells (iNSCs) from Alzheimer’s disease patient-derived fibroblasts.
[Cell Death Discovery]
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Placental Mammals Acquired Functional Sequences in NRK for Regulating the CK2-PTEN-AKT Pathway and Placental Cell Proliferation

Scientists showed the molecular evolution of NCK-interacting kinase-related kinase, which confered its function for inhibiting placental cell proliferation.
[Molecular Biology and Evolution]
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Hydroxysafflor Yellow a Inhibits the Proliferation, Migration, and Invasion of Colorectal Cancer Cells through the PPARγ/PTEN/Akt Signaling Pathway

Researchers clarified the role of hydroxysafflor yellow A in inhibiting colorectal cancer in vitro and the underlying mechanisms.
[Bioengineered]
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Smurf1 Silencing Restores PTEN Expression That Ameliorates Progression of Human Glioblastoma and Sensitizes Tumor Cells to mTORC1/C2 Inhibitor Torin1

Researchers investigated Smurf1 expression in various glioblastoma (GB) cell lines and patient tissues and found Smurf1 loss elevated PTEN levels that interrupted the epidermal growth factor receptor pathway activity.
[iScience]
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