To explore what signaling pathways may be involved, investigators employed heterologous synapse formation assays in which a synaptic adhesion molecule expressed in a nonneuronal cell induced pre- or postsynaptic specializations in cocultured neurons.
[Proceedings of the National Academy of Sciences of the United States of America]
Jiang, X., Sando, R., & Südhof, T. C. (2021). Multiple signaling pathways are essential for synapse formation induced by synaptic adhesion molecules. Proceedings of the National Academy of Sciences, 118(3). https://doi.org/10.1073/pnas.2000173118 Cite
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