Targeting KDM6A Suppresses SREBP1c-Dependent Lipid Metabolism and Prostate Tumorigenesis

Scientists reported that specific homozygous deletion of KDM6A in the adult mouse prostate epithelium strongly inhibited tumor progression initiated by the homozygous loss of PTEN. Mechanistically, KDM6A promoted prostate tumorigenesis and lipid metabolism by binding to the SREBP1c promoter which resulted in increased SREBP1c transcription.
[Cancer Research]
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Parkinson’s Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2-Hydroxypropyl-β-Cyclodextrin Treatment

Investigators evaluated the difference between controls’ and phosphatase and tensin homolog-induced putative kinase 1 (PINK1) patients’ derived neurons in their transition from neuroepithelial stem cells to neurons, allowing them to identify potential pathways to target with repurposed compounds.
[Movement Disorders]
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Molecular Characterization of Biphenotypic Epithelioid and Plexiform Melanoma with Deep Penetrating Nevus (DPN)-Like Features

Scientists investigated a case of melanoma that displayed a dual phenotype: a DPN-like/plexiform portion in conjunction with a conventional epithelioid morphology.
[Pigment Cell & Melanoma Research]
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PTEN Regulates Proliferation and Osteogenesis of Dental Pulp Cells and Adipogenesis of Human Adipose-Derived Stem Cells

Genetic variant was identified with exome sequencing. The human dental pulp cells isolated from a patient with Cowden syndrome were investigated for their proliferation, osteogenesis, adipogenesis, and gene expression compared with controls.
[Oral Diseases]
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Extracellular PKM2 Facilitates Organ-Tissue Fibrosis Progression

The authors reported that myofibroblasts expressed and secreted PKM2. Extracellular PKM2 upregulated arginase-1 expression in myofibroblasts, therefore facilitating proline biosynthesis and subsequent collagen production.
[iScience]
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Circ_0004018 Suppresses Cell Proliferation and Migration in Hepatocellular Carcinoma via miR-1197/PTEN/PI3K/AKT Signaling Pathway

Researchers conducted quantitative reverse transcription PCR to find that circ_0004018 was down-regulated in hepatocellular carcinoma cells. Western blot analysis was performed to detect the protein levels of phosphatase and tensin homologue and related factors of PI3K/AKT signaling pathway.
[Cell Cycle]
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The Transcription Factor ZHX2 Alleviates Nonalcoholic Steatohepatitis by Transcriptional Activation of PTEN

Researchers identified a transcription factor Zinc Fingers and Homeoboxes 2 (ZHX2) in hepatocytes as a protective factor against steatohepatitis. Hepatocyte-specific ablation of ZHX2 exacerbated NASH-related phenotypes in mice, including lipid accumulation, enhanced inflammation, and hepatic fibrosis.
[Hepatology]
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Chemerin Regulates Normal Angiogenesis and Hypoxia-Driven Neovascularization

Chemerin did not affect vascular sprouting during the post-natal development of the network, but rather promoted endothelial cell apoptosis and vessel pruning.
[Angiogenesis]
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Modeling PTEN Overexpression-Induced Microcephaly in Human Brain Organoids

The authors generated a human brain organoid model of increased PTEN dosage. They showed that mild PTEN overexpression led to reduced neural precursor proliferation, premature neuronal differentiation, and the formation of significantly smaller brain organoids.
[Molecular Brain]
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Melatonin Restores Osteoporosis-Impaired Osteogenic Potential of Bone Marrow Mesenchymal Stem Cells and Alleviates Bone Loss through the HGF/PTEN/Wnt/β-Catenin Axis

Real-time qualitative PCR and Western blot analysis were conducted to determine expression of HGF, PTEN, and osteoblast differentiation-related genes in ovariectomy-induced osteoporosis mice and the isolated bone marrow MSCs.
[Therapeutic Advances in Chronic Disease]
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circMRPS35 Promotes Malignant Progression and Cisplatin Resistance in Hepatocellular Carcinoma

Scientists identified a functional RNA – hsa_circ_0000384 (circMRPS35) from public tumor databases using a set of computational analyses, and further identified that circMRPS35 was highly expressed in 35 pairs of hepatocellular carcinoma from patients.
[Molecular Therapy]
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