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A Small-Molecule Cocktail Promotes Mammalian Cardiomyocyte Proliferation and Heart Regeneration

[Cell Stem Cell] Investigators reported a chemical cocktail of five small molecules that promoted adult cardiomyocyte proliferation and heart regeneration.

TMPRSS2-ERG Promotes the Initiation of Prostate Cancer by Suppressing Oncogene-Induced Senescence

[Cancer Gene Therapy] In primary prostate luminal epithelial cells, following inducible oncogenic Kras expression or Pten depletion, TMPRSS2-ERG suppressed oncogene-induced senescence, independent of TP53 induction and RB1 inhibition.

GH Action in Prostate Cancer Cells Promotes Proliferation Limits Apoptosis and Regulates Cancer-Related Gene Expression

[Endocrinology] The authors addressed the species specificity of growth hormone (GH)-GH receptor activity by investigating GH actions in prostate cancer cell lines derived from a mouse Pten deletion model.

Context Dependent Isoform Specific PI3K Inhibition Confers Drug Resistance in Hepatocellular Carcinoma Cells

[BMC Cancer] The bioactivities of inhibitors on PTEN adequate Huh7 and deficient Mahlavu cells were investigated with real time cell growth, cell cycle and cell migration assays.

Bioactivity and miRNome Profiling of Native Extracellular Vesicles in Human Induced Pluripotent Stem Cell-Cardiomyocyte Differentiation

[Advanced Science] Scientists isolated extracellular vesicles (EVs) from key stages of the human induced pluripotent stem cell-cardiomyocyte differentiation and maturation, with the aim of identifying a promising cell biofactory for EV production, and pinpointed the genetic signatures of bioactive EVs.

Extracellular Vesicles Enriched with an Endothelial Cell Pro-Survival microRNA Impacts Skin Tissue Regeneration

[Molecular Therapy-Nucleic Acids] Using a streptozotocin-induced diabetic wound healing mouse model, investigators showed that, compared with miR-scrambled-modulated small extracellular vesicles (sEVs), topical administration of miR-425-5p-modulated sEVs significantly enhanced wound healing, a process mediated by enhanced vascularization and skin re-epithelialization.