Loss of PTEN Expression Is Associated with PI3K Pathway-Dependent Metabolic Reprogramming in Hepatocellular Carcinoma

Researchers discovered that loss of PTEN allowed the tumor metabolic program, a major advance in understanding the carcinogenesis of hepatocellular carcinoma.
[Cell Communication and Signaling]
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E2F7−EZH2 Axis Regulates PTEN/AKT/mTOR Signaling and Glioblastoma Progression

Functional studies showed that E2F7 promoted cell proliferation, cell-cycle progression, cell metastasis and tumorigenicity abilities in vitro and in vivo.
[British Journal of Cancer]
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Single-Cell Transcriptomics Identifies a Distinct Luminal Progenitor Cell Type in Distal Prostate Invagination Tips

Researchers characterized 35,129 cells from mouse prostates, and identified a unique luminal cell typemarked by Tacstd2, Ck4 and Psca expression.
[Nature Genetics]
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Quercetin–Resveratrol Combination for Prostate Cancer Management in TRAMP Mice

Scientists determined the effects of grape antioxidants quercetin and/or resveratrol against prostate cancer in the transgenic adenocarcinoma of mouse prostate (TRAMP)-model in prevention and intervention settings.
[Cancers]
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Oncogenic Smurf1 Promotes PTEN Wild-Type Glioblastoma Growth by Mediating PTEN Ubiquitylation

Smurf1 promotes cell growth and colony formation by accelerating cell cycle and aberrant signaling pathways. In addition, the authors showed that Smurf1 ubiquitylates and degrades phosphatase and tensin homolog.
[Oncogene]
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Long Non-Coding RNA MIR22HG Promotes Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells via PTEN/AKT Pathway

Researchers showed MIR22HG, which has been demonstrated to be involved in the progression of several cancer types, played an important role in regulating bone marrow mesenchymal stem cell osteogenesis.
[Cell Death & Disease]
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PTEN Suppresses Epithelial–Mesenchymal Transition and Cancer Stem Cell Activity by Downregulating Abi1

The authors reconstituted PTEN-deficient breast cancer cells with wild-type and mutant PTEN, demonstrating that restoration of PTEN expression converted cancer cells with mesenchymal traits to an epithelial phenotype and inhibited cancer stem cell activity.
[Scientific Reports]
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Emerging Role of FBXO22 in Carcinogenesis

Scientists summarize the regulatory factors and downstream targets of F-box protein 22 (FBXO22) in cancers, discuss its functions in tumorigenesis, and further highlight the alteration of FBXO22 expression in a variety of human malignancies.
[Cell Death Discovery]
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Emerging Role of FBXO22 in Carcinogenesis

Scientists summarize the regulatory factors and downstream targets of FBXO22 in cancers, discuss its functions in tumorigenesis, and further highlight the alteration of FBXO22 expression in a variety of human malignancies.
[Cell Death Discovery]
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Chromatin Remodeler Znhit1 Preserves Hematopoietic Stem Cell Quiescence by Determining the Accessibility of Distal Enhancers

Investigators found that loss of zinc finger HIT-type containing 1 (Znhit1) led to exhaustion of stem cell pool and impairment of hematopoietic function.
[Leukemia]
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Hydrazinocurcumin and 5-Fluorouracil Enhance Apoptosis and Restrain Tumorigenicity of HepG2 Cells via Disrupting the PTEN-Mediated PI3K/Akt Signaling Pathway

Scientists investigated the role and mechanism of hydrazinocurcumin (HZC) in regulating HepG2 cell apoptosis and tumorigenicity, and its synergistic effects with 5-fluorouracil (5-Fu). HepG2 cells were treated with HZC and/or 5-Fu to analyze the possible synergistic effects on cell proliferation, apoptosis and cell cycle distribution in vitro using EdU staining.
[Biomedicine & PharmacoTherapy]
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