PTEN

[Scientific Reports] The authors investigated the relationship amongst PTEN deletion, L-asparaginase sensitivity and glucose metabolism in T cell acute lymphoblastic leukemia cells.

[Scientific Reports] Researchers investigated the anti-inflammatory and pro-angiogenic roles of human adipose MSC-derived exosomes, focusing on the underlying mechanisms.

[Cancer Prevention Research] The authors demonstrated that δ-tocotrienol effectively inhibited the development of prostate adenocarcinoma in Ptenp-/- mice, which involved inhibition of proliferation and angiogenesis and promotion of apoptosis.

[Molecular Biology Reports] Researchers assessed the suppressing effect of VGB4, a vascular endothelial growth factor (VEGF) antagonist peptide with the binding ability to both VEGF receptor1 and VEGF receptor2, on VEGF-induced proliferation and migration of the human lung adenocarcinoma cell line A549 and the human colon adenocarcinoma cell line HT29.

[Journal of Clinical Investigation] Investigators reported that SUMO-specific protease 7 sensed oxidative stress to maintain the CD8+ T cell metabolic state and antitumor functions.

[Molecular Cancer Research] Researchers found that combining p110β with RAC/PAK1 or tankyrase inhibitors significantly reduced the growth of murine and human CRPC organoids in vitro and in vivo.