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PTEN

Human Umbilical Cord Mesenchymal Stem Cells-Derived Extracellular Vesicles Facilitate the Repair of Spinal Cord Injury via the miR-29b-3p/PTEN/Akt/mTOR Axis

[Cell Death Discovery] Investigators explored the repair effect of human umbilical cord MSCs-derived extracellular vesicles on spinal cord injury.

The Requirement for Pyruvate Dehydrogenase in Leukemogenesis Depends on Cell Lineage

[Cell Metabolism] Investigators compared glucose metabolism in hematopoiesis and leukemia. Thymus T cell progenitors were glucose avid and oxidized more glucose in the tricarboxylic acid cycle through pyruvate dehydrogenase as compared with other hematopoietic cells.

Adaptor SH3BGRL Promotes Breast Cancer Metastasis through PFN1 Degradation by Translational STUB1 Upregulation

[Oncogene] The authors reported that a small adaptor protein, SH3BGRL, was upregulated in the majority of breast cancer patients, especially elevated in those with metastatic relapse, indicating it as a marker for the poor prognosis of breast cancer.

Glioblastoma Therapy: Rationale for a Mesenchymal Stem Cell-based Vehicle to Carry Recombinant Viruses

[Stem Cell Reviews and Reports] Scientists summarize findings to advocate the reactivation of tumor suppressors p53 and PTEN in glioblastoma treatment and use MSCs as a “Trojan horse” to carry oncolytic viral cargo to disseminated tumor beds.

Pax5 Regulates B Cell Immunity by Promoting PI3K Signaling via PTEN Down-Regulation

[Science Immunology] Scientists demonstrated that the loss of Pax5 by conditional mutagenesis in peripheral B lymphocytes led to the strong reduction of B-1a, marginal zone and germinal center B cells as well as plasma cells.

Targeting mTOR Signaling Overcomes Acquired Resistance to Combined BRAF and MEK Inhibition in BRAF-Mutant Melanoma

[Oncogene] In vitro experiments showed that a subset of combination therapy melanoma cells was sensitive to mTORC1 inhibition.

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