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Pck2

Elevated ATGL in Colon Cancer Cells and Cancer Stem Cells Promotes Metabolic and Tumorigenic Reprogramming Reinforced by Obesity

[Oncogenesis] Elevated ATGL levels in human colon cancer cells relative to non-transformed were augmented by an obesity mediator, oleic acid.

Mutant p53 Attenuates Oxidative Phosphorylation and Facilitates Cancer Stemness through Downregulating microRNA-200c-PCK2 Axis in Basal-Like Breast Cancer

[Molecular Cancer Research] The authors demonstrated that CRISPR-mediated knockout of miR-200c induced metabolic features similar to the metabolic rewiring caused by p53 hot-spot mutations, and that impairing this metabolic reprogramming interfered with miR-200c deficiency-induced stemness and transformation.

The Phosphoenolpyruvate Carboxykinase (PEPCK) Inhibitor, 3-Mercaptopicolinic Acid (3-MPA), Induces Myogenic Differentiation in C2C12 Cells

[Scientific Reports] The authors investigated the effect of 3-mercaptopicolinic acid, a phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, on C2C12 muscle cells. They report that Pck2 mRNA was 50–5000-fold higher than Pck1 during C2C12 myogenesis, indicating Pck2 is the predominant PEPCK isoform.

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