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RAS

NDRG1 Enhances the Sensitivity of Cetuximab by Modulating EGFR Trafficking in Colorectal Cancer

[Oncogene] Researchers found that NDRG1 enhanced the sensitivity of cetuximab in colorectal cancer cell lines by inhibiting the expression of epidermal growth factor receptor (EGFR); blocking EGFR phosphorylation and reducing the EGFR distribution in the cell membrane, cytoplasm and nucleus.

Telocytes Promote Hepatocellular Carcinoma by Activating the ERK Signaling Pathway and miR-942-3p/MMP9 Axis

[Cell Death Discovery] Primary telocytes (TCs) from liver para-cancer tissues were cultured in vitro. To verify the role of TCs in hepatocellular carcinoma, a metastatic cancer animal model was established using three types of liver cancer cell lines in vivo.

Tryptophan Improves Porcine Intestinal Epithelial Cell Restitution through the CaSR/Rac1/PLC-γ1 Signaling Pathway

[Food & Function] The authors investigated the effect of tryptophan on cell migration and its underlying mechanism in porcine intestine epithelial cells and showed that tryptophan could modulate IPEC-J2 cell proliferation and enhance cell migration.

Combined Inhibition of SHP2 and CXCR1/2 Promotes Anti-Tumor T Cell Response in NSCLC

[Cancer Discovery] The authors found that SHP2 inhibitor treatment depleted alveolar and M2-like macrophages, induced tumor-intrinsic CCL5/CXCL10 secretion and promoted B and T lymphocyte infiltration in Kras- and Egfr-mutant non-small cell lung cancer.

Integrative Oncogene-Dependency Mapping Identifies RIT1 Vulnerabilities and Synergies in Lung Cancer

[Nature Communications] Scientists investigated the oncogene-specific dependencies conferred by the lung cancer oncogene, RIT1. Genome-wide CRISPR screening in KRAS, EGFR, and RIT1-mutant isogenic lung cancer cells identifies shared and unique vulnerabilities of each oncogene..

RASSF9 Promotes NSCLC Cell Proliferation by Activating the MEK/ERK Axis

[Cell Death Discovery] Scientists examined the potential roles of RAS-associated domain family 9 in non-small cell lung cancer and the underlying mechanisms.

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