ROS production

[Stem Cell Reports] The authors used Duchenne muscular dystrophy-patient-specific human iPSCs to model cardiomyopathic features and unravel novel pathologic insights.

[Nanotoxicology] In this in vitro study scientists assessed the cytotoxic effects of nickel oxide nanoparticles (NiONPs) on human pulmonary artery endothelial cells.

[ACS Applied Materials & interfaces] To overcome the tumor hypoxia and thermal resistance existing in phototherapy, researchers constructed a self-synergistic nanoplatform for tumors by incorporating brusatol, a nuclear factor erythroid 2-related factor (Nrf2) inhibitor, into the silica nanonetwork.

[Cellular & Molecular Immunology] Scientists reported that dedicator of cytokinesis 2 (DOCK2) promoted indispensable antifungal innate immune signaling and proinflammatory gene expression in macrophages.

[PLoS Pathogens] Investigators assessed the influence of COVID-19 plasma hypercytokinemia on the functional responses of myeloid immune cells upon bacterial challenges from acute-phase COVID-19 patients and their corresponding recovery (rec)-phase.

[Environmental Toxicology] Vemurafenib-resistant A375.S2 cells were established, and the functional mechanism of the epidermal growth factor receptor (EGFR), serine–threonine kinase, and the extracellular signal-regulated kinase signaling induced by curcumin was investigated in A375.S2/VR cells in vitro.