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ROS production

Interaction of SARS-CoV-2 with Cardiomyocytes: Insight into the Underlying Molecular Mechanisms of Cardiac Injury and Pharmacotherapy

[Biomedicine & Pharmacotherapy] The authors provide an overview of the pathways involved with cardiomyocyte in COVID-19 subjects to help promoting pharmacotherapies that can protect against SARS-CoV-2-induced cardiac injuries.

Berberine Alleviates Liver Fibrosis through Inducing Ferrous Redox to Activate ROS-Mediated Hepatic Stellate Cells Ferroptosis

[Cell Death Discovery] Researchers investigated the molecular mechanisms underlying the effect of berberine against liver fibrogenesis in thioacetamide and carbon tetrachloride induced mouse liver fibrosis.

Berberine Increases the Expression of Cytokines and Proteins Linked to Apoptosis in Human Melanoma Cells

[Molecular Biology Reports] Researchers reported that berberine has important antiproliferative effects and may be alone or in adjunct therapy a promising candidate for melanoma treatment, a cancer with great incidence and high lethality.

Bi-Phasic Effect of Gelatin in Myogenesis and Skeletal Muscle Regeneration

[Disease Models & Mechanisms] Researchers elaborate on a bi-phasic effect of gelatin in skeletal muscle regeneration, mediated by hormetic effects of reactive oxygen species.

Valproic Acid Disables the Nrf2 Anti-Oxidant Response in Acute Myeloid Leukemia Cells Enhancing Reactive Oxygen Species-Mediated Killing

[British Journal of Cancer] The authors demonstrated that addition of a commonly used anti-epileptic, valproic acid to low dose bezafibrate and medroxyprogesterone acetate (BaP) enhanced killing of acute myeloid leukemia (AML) cell lines/primary AML cells to levels similar to high dose BaP.

CPT2 Downregulation Triggers Stemness and Oxaliplatin Resistance in Colorectal Cancer via Activating the ROS/Wnt/β-Catenin-Induced Glycolytic Metabolism

[Experimental Cell Research] Researchers analyzed carnitine palmitoyltransferase 2 (CPT2) expression in colorectal cancer (CRC) tissues and cells. CPT2 was overexpressed in CRC cell lines, and its effects and molecular mechanism on the proliferation, glycolysis, stemness, and oxaliplatin sensitivity were investigated.

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