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ROS production

Three-Dimensional Covalent Organic Frameworks with Cross-Linked Pores for Efficient Cancer Immunotherapy

[Nano Letters] Mechanism studies revealed that after linking these immunogenic cell death inert monomers into the covalent organic frameworks (COFs) backbone, the optical properties of these COFs could be systematically tuned to achieve excellent reactive oxygen species production performance.

SPRY4 Acts as an Indicator of Osteoarthritis Severity and Regulates Chondrocyte Hypertrophy and ECM Protease Expression

[NPJ Regenerative Medicine] Using SPRY4 gene delivery into healthy and degenerated chondrocytes, investigators elucidated the role of SPRY4 in preventing chondrocyte hypertrophy. In addition to using the human cartilage tissues with the destabilization of the model in Sprague-Dawley rats, the role of SPRY4 in cartilage tissues and chondrocytes was explored through their molecular and histological analysis.

Bioglass Promotes Wound Healing by Inhibiting Endothelial Cell Pyroptosis through Regulation of the Connexin 43/Reactive Oxygen Species (ROS) Signaling Pathway

[Laboratory Investigation] Researchers investigated the possible effect of bioactive glass (BG) on pyroptosis in wound healing both in vivo and in vitro and showed that BG could accelerate wound closure, granulation formation, collagen deposition, and angiogenesis.

Effect of Endothelial Progenitor Cell-Derived Extracellular Vesicles on Endothelial Cell Ferroptosis and Atherosclerotic Vascular Endothelial Injury

[Cell Death Discovery] Researchers focused on the role of endothelial progenitor cell-secreted extracellular vesicles in atherosclerosis.

All-Purpose Nanostrategy Based on Dose Deposition Enhancement, Cell Cycle Arrest, DNA Damage, and ROS Production as Prostate Cancer Radiosensitizer for Potential Clinical Translation

[Nanoscale] Scientists proposed an ‘all-purpose’ nanostrategy based on dose deposition enhancement, cell cycle arrest, and ROS production as prostate cancer radiosensitizer for potential clinical translation.

Mitochondrial Fragmentation Triggers Ineffective Hematopoiesis in Myelodysplastic Syndromes

[Cancer Discovery] Scientists demonstrated that overwhelming mitochondrial fragmentation in mutant hematopoietic stem cells and progenitors triggered ineffective hematopoiesis in myelodysplastic syndromes.

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