ROS production

[Proceedings of the National Academy of Sciences of the United States of America] Scientists generated reactive oxygen species (ROS)-sensitive fluorescent sensors targeted to different subnuclear compartments in neonatal rat ventricular cardiomyocytes, which allowed them to determine the spatial localization of ROS in cardiomyocyte nuclei upon manipulation of mitochondrial respiration.

[Toxicology in Vitro] Investigators evaluated the effects of electronic cigarette (EC) refill fluids and EC exhaled aerosol residue on cultured human keratinocytes and MatTek EpiDerm™, a 3D air liquid interface human skin model.

[Signal Transduction and Targeted Therapy] Investigators identified that SARS-CoV-2 ORF3a and host hypoxia-inducible factor-1α (HIF-1α) play key roles in the virus infection and pro-inflammatory responses.

[Oncogene] Researchers explored the inhibitory role of ITLN1 in the tumor-permissive microenvironment that existed during the first occurrence and subsequent development of colorectal carcinoma.

[Cancer Discovery] Scientists demonstrated that an oncogenic mutant form of NPM1 (NPM1c) impaired mitochondrial function. NPM1c also hampered formation of PML nuclear bodies, which are regulators of mitochondrial fitness and key senescence effectors.

[Cell Biology International] Human umbilical cord MSCs-derived exosomal miR-100-5p inhibited cyclic strain-induced reactive oxygen species production and apoptosis in primary articular chondrocytes.