Core-Binding Factor Leukemia Hijacks the T-cell–Prone PU.1 Antisense Promoter

Researchers showed that transcriptional downregulation of PU.1 was an active process involving an alternative promoter in intron 3 that was induced by RUNX transcription factors driving noncoding antisense transcription.
[Blood]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Regulatory Association of Long Noncoding RNAs and Chromatin Accessibility Facilitates Erythroid Differentiation

The authors employed HSCs, multipotent progenitor cells, common myeloid progenitor cells, megakaryocyte-erythroid progenitor cells, and erythroblasts from human cord blood as an erythroid differentiation model to explore the coordinated regulatory functions of lncRNAs and chromatin accessibility by integrating RNA-Seq and ATAC-Seq data.
[Blood Advances]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
AbstractFull Article
Bookmark

No account yet? Register

Share

Insufficiency of FZR1 Disturbs HSC Quiescence by Inhibiting Ubiquitin-Dependent Degradation of RUNX1 in Aplastic Anemia

Investigators reported that FZR1 was downregulated in severe aplastic anemia HSCs compared with healthy control and was associated with decreased quiescence of HSCs.
[Leukemia]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Single-Cell and Bulk Transcriptomics of the Liver Reveals Potential Targets of NASH with Fibrosis

Scientists profiled 17,810 non-parenchymal cells derived from six healthy human livers, which enabled the identification of potential intercellular signaling axes and master regulators responsible for the activation of hepatic stellate cells during fibrogenesis.
[Scientific Reports]
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Enhancer Recruitment of Transcription Repressors RUNX1 and TLE3 by Mis-Expressed FOXC1 Blocks Differentiation in Acute Myeloid Leukemia

Scientists highlighted RUNX1 and CEBPA transcription factor swapping as a feature of leukemia cell differentiation and revealed that FOXC1 prevented this by stabilizing enhancer binding of a RUNX1/HDAC1/TLE3 transcription repressor complex to oncogenic effect.
[Cell Reports]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

Share

Mitochondrial Fragmentation Triggers Ineffective Hematopoiesis in Myelodysplastic Syndromes

Scientists demonstrated that overwhelming mitochondrial fragmentation in mutant hematopoietic stem cells and progenitors triggered ineffective hematopoiesis in myelodysplastic syndromes.
[Cancer Discovery]
[zotpress userid=’7992332′ items=’XMRTAWRF’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

An Erythroid to Myeloid Cell Fate Conversion Is Elicited by LSD1 Inactivation

The authors examined the consequences of conditional inactivation of Lsd1 in adult red blood cells using a new Gata1creERT2 BAC transgene. The analogous phenotype was observed in human hematopoietic stem and progenitor cells, coincident with induction of myeloid transcription factors.
[Blood]
[zotpress userid=’7992332′ items=’R5HVQCQR’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Myofibroblast Transcriptome Indicates SFRP2hi Fibroblast Progenitors in Systemic Sclerosis Skin

Researchers showed that systemic sclerosis skin dermal myofibroblasts arose in two steps from an SFRP2hi/DPP4-expressing progenitor fibroblast population.
[Nature Communications]
[zotpress userid=” items=’3CA7KMBN’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Sequential Regulation of Hemogenic Fate and Hematopoietic Stem and Progenitor Cell Formation from Arterial Endothelium by Ezh1/2

Single-cell RNA sequencing across ezh1 genotypes revealed a dropout of ezh1+/− cells among arterial endothelium associated with positive regulation of gene transcription.
[Stem Cell Reports]
[zotpress userid=’6445218′ items=’XHEAA4ME’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Allogeneic Stem Cell Transplantation for AML Patients with RUNX1 Mutation in First Complete Remission: A Study on Behalf of the Acute Leukemia Working Party of the EBMT

Researchers performed a retrospective, registry-based analysis to elucidate the prognostic value of runt-related transcription factor 1 (RUNX1) mutation after allogeneic stem cell transplantation for AML patients.
[Bone Marrow Transplantation]
[zotpress userid=” items=’LPWA3NN2′ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Towards Prevention of Childhood ALL by Early-Life Immune Training

A first genetic hit led to the expansion of pre-leukemic B-cell clones, which were detectable in healthy newborn cord blood. These pre-leukemic clones gave rise to clinically overt leukemia in only about 0.2% of carriers.
[Blood]
[zotpress userid=” items=’AP7ULL5H’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share
Share