The authors revealed that TGFβ1 could significantly upregulate miR-455 and miR-210 expression in synoviocytes. The upregulated miRNAs could be secreted into the extracellular environment and prevent cartilage degeneration.
[Molecular Therapy-Nucleic Acids]
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Zhao, X., Meng, F., Hu, S., Yang, Z., Huang, H., Pang, R., Wen, X., Kang, Y., & Zhang, Z. (2020). The synovium attenuates cartilage degeneration in knee osteoarthritis through activation of the Smad2/3-Runx1 cascade and subsequent upregulation of chondrogenesis-related miRNAs. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.10.004 Cite