The Synovium Attenuates Cartilage Degeneration in Knee Osteoarthritis through Activation of the Smad2/3-Runx1 Cascade and Subsequent Upregulation of Chondrogenesis-Related miRNAs

The authors revealed that TGFβ1 could significantly upregulate miR-455 and miR-210 expression in synoviocytes. The upregulated miRNAs could be secreted into the extracellular environment and prevent cartilage degeneration.
[Molecular Therapy-Nucleic Acids]
Zhao, X., Meng, F., Hu, S., Yang, Z., Huang, H., Pang, R., Wen, X., Kang, Y., & Zhang, Z. (2020). The synovium attenuates cartilage degeneration in knee osteoarthritis through activation of the Smad2/3-Runx1 cascade and subsequent upregulation of chondrogenesis-related miRNAs. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.10.004 Cite
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

CHD7 and Runx1 Interaction Provides a Braking Mechanism for Hematopoietic Differentiation

Genetic disruption of the chromatin remodeler chromodomain-helicase-DNA-binding protein 7 (CHD7) expanded phenotypic hematopoietic stem and progenitor cells, erythroid, and myeloid lineages in zebrafish and mouse embryos.
[Proceedings of the National Academy of Sciences of the United States of America]
Hsu, J., Huang, H.-T., Lee, C.-T., Choudhuri, A., Wilson, N. K., Abraham, B. J., Moignard, V., Kucinski, I., Yu, S., Hyde, R. K., Tober, J., Cai, X., Li, Y., Guo, Y., Yang, S., Superdock, M., Trompouki, E., Calero-Nieto, F. J., Ghamari, A., … Zon, L. I. (2020). CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2003228117 Cite
Abstract
Bookmark

No account yet? Register

0
Share

LncRNA Hoxaas3 Promotes Lung Fibroblast Activation and Fibrosis by Targeting miR-450b-5p to Regulate Runx1

Researchers found long noncoding RNA (lncRNA) Hoxaas3 was up-regulated in the mice model of BLM-induced pulmonary fibrosis and TGF-β1-induced fibrogenesis in lung fibroblasts.
[Cell Death & Disease]
Full Article
Bookmark

No account yet? Register

0
Share

Malignant Transformation Involving CXXC4 Mutations Identified in a Leukemic Progression Model of Severe Congenital Neutropenia

To investigate how the combination of CSF3 therapy and CSF3R and RUNX1 mutations contributes to acute myeloid leukemia (AML) development, researchers make use of mouse models, severe congenital neutropenia (SCN)-derived iPSCs, and SCN and SCN-AML patient samples.
[Cell Reports Medicine]
Olofsen, P. A., Fatrai, S., Strien, P. M. H. van, Obenauer, J. C., Looper, H. W. J. de, Hoogenboezem, R. M., Erpelinck-Verschueren, C. A. J., Vermeulen, M. P. W. M., Roovers, O., Haferlach, T., Jansen, J. H., Ghazvini, M., Bindels, E. M. J., Schneider, R. K., Pater, E. M. de, & Touw, I. P. (2020). Malignant Transformation Involving CXXC4 Mutations Identified in a Leukemic Progression Model of Severe Congenital Neutropenia. Cell Reports Medicine, 1(5). https://doi.org/10.1016/j.xcrm.2020.100074 Cite
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production

The authors demonstrated that NLRP3 inflammasome-mediated interleukin-1-beta signaling drives hematopoietic stem and progenitor cell production in response to metabolic activity.
[Developmental Cell]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

Prognostic Impact of TP53 Mutation, Monosomal Karyotype, and Prior Myeloid Disorder in Nonremission Acute Myeloid Leukemia at allo-HSCT

Researchers analyzed prognostic gene mutations by targeted next-generation sequencing to identify predisposing factors for predicting overall survival at one month before transplantation. They enrolled 120 patients with nonremission acute myeloid leukemia who underwent first allogeneic hematopoietic stem cell transplantation (allo-HSCT) between 2005 and 2018.
[Bone Marrow Transplantation]
Abstract
Bookmark

No account yet? Register

0
Share

Evidence for a Role of RUNX1 as Recombinase Cofactor for TCRβ Rearrangements and Pathological Deletions in ETV6-RUNX1 ALL

Scientists employed a RUNX1 knock-out mouse model and demonstrate by deep TCRβ sequencing, immunostaining and chromatin immunoprecipitation that RUNX1 binds to the initiation site of TCRβ rearrangement and its homozygous inactivation induced severe structural changes of the rearranged TCRβ gene, whereas heterozygous inactivation had almost no impact.
[Scientific Reports]
Abstract
Bookmark

No account yet? Register

0
Share
Share