The T-Box Transcription Factor Eomesodermin Governs Haemogenic Competence of Yolk Sac Mesodermal Progenitors

Investigators demonstrated using an ESC model that transient expression of the T-box transcription factor Eomesodermin governs haemogenic competency of extra-embryonic mesoderm.
[Nature Cell Biology]
Harland, L. T. G., Simon, C. S., Senft, A. D., Costello, I., Greder, L., Imaz-Rosshandler, I., Göttgens, B., Marioni, J. C., Bikoff, E. K., Porcher, C., de Bruijn, M. F. T. R., & Robertson, E. J. (2021). The T-box transcription factor Eomesodermin governs haemogenic competence of yolk sac mesodermal progenitors. Nature Cell Biology, 23(1), 61–74. https://doi.org/10.1038/s41556-020-00611-8 Cite
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The T-Box Transcription Factor Eomesodermin Governs Hemogenic Competence of Yolk Sac Mesodermal Progenitors

Investigators demonstrated using an embryonic stem cell model that transient expression of the T-box transcription factor Eomesodermin governed hemogenic competency of extra-embryonic mesoderm.
[Nature Cell Biology]
Harland, L. T. G., Simon, C. S., Senft, A. D., Costello, I., Greder, L., Imaz-Rosshandler, I., Göttgens, B., Marioni, J. C., Bikoff, E. K., Porcher, C., de Bruijn, M. F. T. R., & Robertson, E. J. (2021). The T-box transcription factor Eomesodermin governs haemogenic competence of yolk sac mesodermal progenitors. Nature Cell Biology, 23(1), 61–74. https://doi.org/10.1038/s41556-020-00611-8 Cite
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Different Mutant RUNX1 Oncoproteins Program Alternate Hematopoietic Differentiation Trajectories

Scientists showed that each class of mutant RUNX1 deregulated endogenous RUNX1 function by a different mechanism, leading to specific alterations in developmentally controlled transcription factor binding and chromatin programming.
[Life Science Alliance]
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Advances in Germline Predisposition to Acute Leukemias and Myeloid Neoplasms

The authors highlight the different genetic pathways impacted by germline mutations that can ultimately lead to the development of familial and sporadic hematological malignancies, including acute lymphoblastic leukemia, acute myeloid leukemia and myelodysplastic syndrome.
[Nature Reviews Cancer]
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SON Inhibits Megakaryocytic Differentiation via Repressing RUNX1 and the Megakaryocytic Gene Expression Program in Acute Megakaryoblastic Leukemia

Scientists report that SON, a chromosome 21-encoded DNA- and RNA-binding protein, inhibits megakaryocytic differentiation by suppressing RUNX1 and the megakaryocytic gene expression program.
[Cancer Gene Therapy]
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The Synovium Attenuates Cartilage Degeneration in Knee Osteoarthritis through Activation of the Smad2/3-Runx1 Cascade and Subsequent Upregulation of Chondrogenesis-Related miRNAs

The authors revealed that TGFβ1 could significantly upregulate miR-455 and miR-210 expression in synoviocytes. The upregulated miRNAs could be secreted into the extracellular environment and prevent cartilage degeneration.
[Molecular Therapy-Nucleic Acids]
Zhao, X., Meng, F., Hu, S., Yang, Z., Huang, H., Pang, R., Wen, X., Kang, Y., & Zhang, Z. (2020). The synovium attenuates cartilage degeneration in knee osteoarthritis through activation of the Smad2/3-Runx1 cascade and subsequent upregulation of chondrogenesis-related miRNAs. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.10.004 Cite
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CHD7 and Runx1 Interaction Provides a Braking Mechanism for Hematopoietic Differentiation

Genetic disruption of the chromatin remodeler chromodomain-helicase-DNA-binding protein 7 (CHD7) expanded phenotypic hematopoietic stem and progenitor cells, erythroid, and myeloid lineages in zebrafish and mouse embryos.
[Proceedings of the National Academy of Sciences of the United States of America]
Hsu, J., Huang, H.-T., Lee, C.-T., Choudhuri, A., Wilson, N. K., Abraham, B. J., Moignard, V., Kucinski, I., Yu, S., Hyde, R. K., Tober, J., Cai, X., Li, Y., Guo, Y., Yang, S., Superdock, M., Trompouki, E., Calero-Nieto, F. J., Ghamari, A., … Zon, L. I. (2020). CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2003228117 Cite
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LncRNA Hoxaas3 Promotes Lung Fibroblast Activation and Fibrosis by Targeting miR-450b-5p to Regulate Runx1

Researchers found long noncoding RNA (lncRNA) Hoxaas3 was up-regulated in the mice model of BLM-induced pulmonary fibrosis and TGF-β1-induced fibrogenesis in lung fibroblasts.
[Cell Death & Disease]
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Malignant Transformation Involving CXXC4 Mutations Identified in a Leukemic Progression Model of Severe Congenital Neutropenia

To investigate how the combination of CSF3 therapy and CSF3R and RUNX1 mutations contributes to acute myeloid leukemia (AML) development, researchers make use of mouse models, severe congenital neutropenia (SCN)-derived iPSCs, and SCN and SCN-AML patient samples.
[Cell Reports Medicine]
Olofsen, P. A., Fatrai, S., Strien, P. M. H. van, Obenauer, J. C., Looper, H. W. J. de, Hoogenboezem, R. M., Erpelinck-Verschueren, C. A. J., Vermeulen, M. P. W. M., Roovers, O., Haferlach, T., Jansen, J. H., Ghazvini, M., Bindels, E. M. J., Schneider, R. K., Pater, E. M. de, & Touw, I. P. (2020). Malignant Transformation Involving CXXC4 Mutations Identified in a Leukemic Progression Model of Severe Congenital Neutropenia. Cell Reports Medicine, 1(5). https://doi.org/10.1016/j.xcrm.2020.100074 Cite
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Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production

The authors demonstrated that NLRP3 inflammasome-mediated interleukin-1-beta signaling drives hematopoietic stem and progenitor cell production in response to metabolic activity.
[Developmental Cell]
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Prognostic Impact of TP53 Mutation, Monosomal Karyotype, and Prior Myeloid Disorder in Nonremission Acute Myeloid Leukemia at allo-HSCT

Researchers analyzed prognostic gene mutations by targeted next-generation sequencing to identify predisposing factors for predicting overall survival at one month before transplantation. They enrolled 120 patients with nonremission acute myeloid leukemia who underwent first allogeneic hematopoietic stem cell transplantation (allo-HSCT) between 2005 and 2018.
[Bone Marrow Transplantation]
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