RUNX1

[Haematologica] Researchers performed cytogenetic, single nucleotide polymorphism array and next generation sequencing analyses on samples from 210 patients aged above 60 years from the UKALL14 and UKALL60+ clinical trials.

[Blood Cancer Journal] To obtain a comprehensive picture of composite genetic driver events and clonal dynamics in subtypes of pediatric acute lymphoblastic leukemia, scientists analyzed tumor-normal whole genome sequencing and expression data from 361 newly diagnosed patients.

[Scientific Reports] Researchers proposed that cardiomyocyte-driven paracrine signaling, which likely involves Notch1, directs subsequent trans-differentiation of endo- and epicardial cells.

[Blood Advances] The authors employed HSCs, multipotent progenitor cells, common myeloid progenitor cells, megakaryocyte-erythroid progenitor cells, and erythroblasts from human cord blood as an erythroid differentiation model to explore the coordinated regulatory functions of lncRNAs and chromatin accessibility by integrating RNA-Seq and ATAC-Seq data.

[Blood] Researchers showed that transcriptional downregulation of PU.1 was an active process involving an alternative promoter in intron 3 that was induced by RUNX transcription factors driving noncoding antisense transcription.

[Leukemia] Investigators reported that FZR1 was downregulated in severe aplastic anemia HSCs compared with healthy control and was associated with decreased quiescence of HSCs.