RUNX1

[Scientific Reports] Scientists profiled 17,810 non-parenchymal cells derived from six healthy human livers, which enabled the identification of potential intercellular signaling axes and master regulators responsible for the activation of hepatic stellate cells during fibrogenesis.

[Cell Reports] Scientists highlighted RUNX1 and CEBPA transcription factor swapping as a feature of leukemia cell differentiation and revealed that FOXC1 prevented this by stabilizing enhancer binding of a RUNX1/HDAC1/TLE3 transcription repressor complex to oncogenic effect.

[Cancer Discovery] Scientists demonstrated that overwhelming mitochondrial fragmentation in mutant hematopoietic stem cells and progenitors triggered ineffective hematopoiesis in myelodysplastic syndromes.

[Blood] The authors examined the consequences of conditional inactivation of Lsd1 in adult red blood cells using a new Gata1creERT2 BAC transgene. The analogous phenotype was observed in human hematopoietic stem and progenitor cells, coincident with induction of myeloid transcription factors.

[Nature Communications] Researchers showed that systemic sclerosis skin dermal myofibroblasts arose in two steps from an SFRP2hi/DPP4-expressing progenitor fibroblast population.

[Stem Cell Reports] Single-cell RNA sequencing across ezh1 genotypes revealed a dropout of ezh1+/− cells among arterial endothelium associated with positive regulation of gene transcription.