RUNX3 Is Up-Regulated in Abdominal Aortic Aneurysm and Regulates the Function of Vascular Smooth Muscle Cells by Regulating TGF-β1

Scientists investigated the role of Runt-related transcription factor 3 (RUNX3) in extracellular matrix remodelling and vascular smooth muscle cells function, and further explored the underlying mechanism.
[Journal of Molecular Histology]
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Runx3 Is Required for Oncogenic Myc Upregulation in p53-Deficient Osteosarcoma

Scientists detected prominent RUNX3/Runx3 expression in human and mouse p53-deficient osteosarcoma and showed that p53 deficiency promoted osteosarcomagenesis in human and mouse by allowing Runx3 to induce oncogenic Myc expression.
[Oncogene]
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Lymph Node Stromal Cell–Intrinsic MHC Class II Expression Promotes MHC Class I–Restricted CD8 T Cell Lineage Conversion to Regulatory CD4 T Cells

Scientists examined the cellular and molecular elements that promote CD8-to-CD4 lineage conversion and the development of CI-Treg cells in mice.
[Journal of Immunology]
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Alternative Splicing of the Inhibitory Immune Checkpoint Receptor SLAMF6 Generates a Dominant Positive Form, Boosting T Cell Effector Functions

Scientists showed that in humans, SLAMF6 has three splice isoforms involving its V-domain. Although the canonical receptor inhibited T-cell activation through SAP recruitment, the short isoform SLAMF6∆17-65 had a strong agonistic effect. T
[Cancer Immunology Research]
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In Vivo CD8+ T Cell CRISPR Screening Reveals Control by Fli1 in Infection and Cancer

Scientists developed an in vivo T cell CRISPR screening platform and identified a key mechanism restraining T EFF biology through the ETS family TF, Fli1.
[Cell]
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Master Regulators and Cofactors of Human Neuronal Cell Fate Specification Identified by CRISPR Gene Activation Screens

Using multiplexed gene regulation with orthogonal CRISPR systems, researchers demonstrated improved neuronal differentiation with concurrent activation and repression of target genes, underscoring the power of CRISPR-based gene regulation for programming complex cellular phenotypes.
[Cell Reports]
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Transgenerational Inheritance of Impaired Larval T Cell Development in Zebrafish

Investigators describe a viable hypomorphic allele of dnmt1 in zebrafish that caused widespread demethylation of CpG dinucleotides in sperm and somatic tissues.
[Nature Communications]
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