RUNX3

[British Journal of Cancer] The authors explore hepcidin in HCC, presenting the levels of tissue and serum hepcidin and explaining the mechanisms that contribute to hepcidin reduction in HCC.

[Science Immunology] Researchers investigated how changes to naive CD8+ T cell gene expression depended on the basic leucine zipper ATF-like transcription factor Batf, which was essential for the early phases of the process.

[Journal of Molecular Histology] Scientists investigated the role of Runt-related transcription factor 3 (RUNX3) in extracellular matrix remodelling and vascular smooth muscle cells function, and further explored the underlying mechanism.

[Oncogene] Scientists detected prominent RUNX3/Runx3 expression in human and mouse p53-deficient osteosarcoma and showed that p53 deficiency promoted osteosarcomagenesis in human and mouse by allowing Runx3 to induce oncogenic Myc expression.

[Journal of Immunology] Scientists examined the cellular and molecular elements that promote CD8-to-CD4 lineage conversion and the development of CI-Treg cells in mice.

[Cancer Immunology Research] Scientists showed that in humans, SLAMF6 has three splice isoforms involving its V-domain. Although the canonical receptor inhibited T-cell activation through SAP recruitment, the short isoform SLAMF6∆17-65 had a strong agonistic effect. T