When grown under the same stem cell enriching conditions, SHH subgroup medulloblastoma cell lines established tight, highly reproducible 3D spheroids that could be maintained for weeks in culture and formed pathophysiological oxygen gradients.
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Functionally, silencing of LINC01426 obviously suppressed the proliferation, migration, epithelial–mesenchymal transition, and stemness of lung adenocarcinoma cells.
[Cell Death & Disease]
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Scientists report that inhibition of the sonic hedgehog pathway by Gli1 siRNA or by cyclopamine and GANT61 reduced BMI1 and SOX2 expression in SW1736 and KAT-18 cells, two anaplastic thyroid cancer cell lines.
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Researchers presented a versatile optogenetic toolbox of artificial multi-headed myosin motors that could move bidirectionally within long cellular extensions and allowed for the selective transport of GFP-tagged cargo with light.
[Nature Cell Biology]
Researchers identified bidirectional crosstalk between the neural and the vascular compartment of the developing CNS required for oligodendrocyte precursor cell specification.
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Paredes, I., Vieira, J. R., Shah, B., Ramunno, C. F., Dyckow, J., Adler, H., Richter, M., Schermann, G., Giannakouri, E., Schirmer, L., Augustin, H. G., & Ruiz de Almodóvar, C. (2021). Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor–endothelial cell crosstalk. Nature Neuroscience, 1–11. https://doi.org/10.1038/s41593-020-00788-z Cite
Scientists investigated how Hedgehog pathway inhibition reprogramed the pancreatic ductal adenocarcinoma microenvironment.
[Clinical Cancer Research]
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Steele, N. G., Biffi, G., Kemp, S. B., Zhang, Y., Drouillard, D., Syu, L.-J., Hao, Y., Oni, T. E., Brosnan, E., Elyada, E., Doshi, A., Hansma, C., Espinoza, C., Abbas, A., The, S., Irizarry-Negron, V. M., Halbrook, C. J., Franks, N., Hoffman, M., … Magliano, M. P. di. (2021). Inhibition of Hedgehog signaling alters fibroblast composition in pancreatic cancer. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-3715 Cite
Scientists investigated the interaction between macrophages and fibrosis‐associated alveolar epithelial cells using a bleomycin‐induced mouse pulmonary fibrosis model and a co‐culture system.
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Scientists report that miR-506-3p expression was markedly reduced in erlotinib-resistant (ER) cells. They identified Sonic Hedgehog as a novel target of miR-506-3p, aberrantly activated in ER cells.
[International Journal of Molecular Sciences]
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To define the mechanisms linking proliferation and apoptotic threshold, researchers examined the effect of conditionally deleting Bcl2l1, the gene that codes the antiapoptotic protein BCL-xL, in cerebellar granule neuron progenitors, and of co-deleting Bcl2l1 homologs, antiapoptotic Mcl-1, or pro-apoptotic Bax.
[Cell Death & Differentiation]
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Veleta, K. A., Cleveland, A. H., Babcock, B. R., He, Y.-W., Hwang, D., Sokolsky-Papkov, M., & Gershon, T. R. (2020). Antiapoptotic Bcl-2 family proteins BCL-xL and MCL-1 integrate neural progenitor survival and proliferation during postnatal cerebellar neurogenesis. Cell Death & Differentiation, 1–14. https://doi.org/10.1038/s41418-020-00687-7 Cite
Investigators reprogrammed human synovial fluid‐derived MSCs into induced pluripotent stem cells (iPSCs) using six reprogramming factors and reverted the iPSCs back to MSCs, as an approach to cell rejuvenation.
Foxl1 expression was transiently upregulated only in connective tissue cells during the early period of metamorphic climax and was the highest just beneath the proliferating stem/progenitor cells.
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