NKX6-1 Mediates Cancer Stem-Like Properties and Regulates Sonic Hedgehog Signaling in Leiomyosarcoma

NKX6-1 enhanced in vitro tumor cell aggressiveness via upregulation of cell proliferation and anchorage-independent growth and promoted in vivo tumor growth.
[Journal of Biomedical Science]
Su, P.-H., Huang, R.-L., Lai, H.-C., Chen, L.-Y., Weng, Y.-C., Wang, C.-C., & Wu, C.-C. (2021). NKX6-1 mediates cancer stem-like properties and regulates sonic hedgehog signaling in leiomyosarcoma. Journal of Biomedical Science, 28(1), 32. https://doi.org/10.1186/s12929-021-00726-6 Cite
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Disease-Relevant Single Cell Photonic Signatures Identify S100β Stem Cells and their Myogenic Progeny in Vascular Lesions

Researchers evaluated single cell photonics as a discriminator of cell phenotype in vitro before the presence of vascular stem cells within vascular lesions.
[Stem Cell Reviews and Reports]
Molony, C., King, D., Di Luca, M., Kitching, M., Olayinka, A., Hakimjavadi, R., Julius, L. A. N., Fitzpatrick, E., Gusti, Y., Burtenshaw, D., Healy, K., Finlay, E. K., Kernan, D., Llobera, A., Liu, W., Morrow, D., Redmond, E. M., Ducrée, J., & Cahill, P. A. (2021). Disease-Relevant Single Cell Photonic Signatures Identify S100β Stem Cells and their Myogenic Progeny in Vascular Lesions. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-021-10125-x Cite
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Acetylation of KLF5 Maintains EMT and Tumorigenicity to Cause Chemoresistant Bone Metastasis in Prostate Cancer

Investigators report that bone-borne TGF-β induced the acetylation of transcription factor KLF5 in prostate cancer bone metastases, and acetylated KLF5 caused osteoclastogenesis and bone metastatic lesions by activating CXCR4, which led to IL-11 secretion, and stimulated SHH/IL-6 paracrine signaling.
[Nature Communications]
Zhang, B., Li, Y., Wu, Q., Xie, L., Barwick, B., Fu, C., Li, X., Wu, D., Xia, S., Chen, J., Qian, W. P., Yang, L., Osunkoya, A. O., Boise, L., Vertino, P. M., Zhao, Y., Li, M., Chen, H.-R., Kowalski, J., … Dong, J.-T. (2021). Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer. Nature Communications, 12(1), 1714. https://doi.org/10.1038/s41467-021-21976-w Cite
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Linking Metabolic Dysfunction with Cardiovascular Diseases: Brn-3b/POU4F2 Transcription Factor in Cardiometabolic Tissues in Health and Disease

Scientists explore the emerging evidence that supports novel and important roles for the POU4F2/Brn-3b transcription factor in controlling cellular genes that regulate cardiometabolic function.
[Cell Death & Disease]
Budhram-Mahadeo, V. S., Solomons, M. R., & Mahadeo-Heads, E. A. O. (2021). Linking metabolic dysfunction with cardiovascular diseases: Brn-3b/POU4F2 transcription factor in cardiometabolic tissues in health and disease. Cell Death & Disease, 12(3), 1–13. https://doi.org/10.1038/s41419-021-03551-9 Cite
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Exovesicular-Shh Confers Imatinib Resistance by Upregulating Bcl2 Expression in Chronic Myeloid Leukemia with Variant Chromosomes

The authors identified the molecular mechanism of Sonic hedgehog (Shh)-mediated mutation-independent Imatinib resistance that is most relevant for treating chronic myeloid leukemia-variants and non-compliant patients.
[Cell Death & Disease]
Anusha, Dalal, H., Subramanian, S., P, S. V., Gowda, D. A., H, K., Damodar, S., & Vyas, N. (2021). Exovesicular-Shh confers Imatinib resistance by upregulating Bcl2 expression in chronic myeloid leukemia with variant chromosomes. Cell Death & Disease, 12(3), 1–17. https://doi.org/10.1038/s41419-021-03542-w Cite
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3D Spheroid Models of Pediatric SHH Medulloblastoma Mimic Tumor Biology, Drug Response and Metastatic Dissemination

When grown under the same stem cell enriching conditions, SHH subgroup medulloblastoma cell lines established tight, highly reproducible 3D spheroids that could be maintained for weeks in culture and formed pathophysiological oxygen gradients.
[Scientific Reports]
Roper, S. J., Linke, F., Scotting, P. J., & Coyle, B. (2021). 3D spheroid models of paediatric SHH medulloblastoma mimic tumour biology, drug response and metastatic dissemination. Scientific Reports, 11(1), 4259. https://doi.org/10.1038/s41598-021-83809-6 Cite
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Upregulation of LINC01426 Promotes the Progression and Stemness in Lung Adenocarcinoma by Enhancing the Level of SHH Protein to Activate the Hedgehog Pathway

Functionally, silencing of LINC01426 obviously suppressed the proliferation, migration, epithelial–mesenchymal transition, and stemness of lung adenocarcinoma cells.
[Cell Death & Disease]
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Targeting the Sonic Hedgehog Pathway to Suppress the Expression of the Cancer Stem Cell (CSC)—Related Transcription Factors and CSC-Driven Thyroid Tumor Growth

Scientists report that inhibition of the sonic hedgehog pathway by Gli1 siRNA or by cyclopamine and GANT61 reduced BMI1 and SOX2 expression in SW1736 and KAT-18 cells, two anaplastic thyroid cancer cell lines.
[Cancers]
Lu, Y., Zhu, Y., Deng, S., Chen, Y., Li, W., Sun, J., & Xu, X. (2021). Targeting the Sonic Hedgehog Pathway to Suppress the Expression of the Cancer Stem Cell (CSC)—Related Transcription Factors and CSC-Driven Thyroid Tumor Growth. Cancers, 13(3), 418. https://doi.org/10.3390/cancers13030418 Cite
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Optogenetic Manipulation of Cellular Communication Using Engineered Myosin Motors

Researchers presented a versatile optogenetic toolbox of artificial multi-headed myosin motors that could move bidirectionally within long cellular extensions and allowed for the selective transport of GFP-tagged cargo with light.
[Nature Cell Biology]
Zhang, Z., Denans, N., Liu, Y., Zhulyn, O., Rosenblatt, H. D., Wernig, M., & Barna, M. (2021). Optogenetic manipulation of cellular communication using engineered myosin motors. Nature Cell Biology, 1–11. https://doi.org/10.1038/s41556-020-00625-2 Cite
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Oligodendrocyte Precursor Cell Specification Is Regulated by Bidirectional Neural Progenitor–Endothelial Cell Crosstalk

Researchers identified bidirectional crosstalk between the neural and the vascular compartment of the developing CNS required for oligodendrocyte precursor cell specification.
[Nature Neuroscience]
Paredes, I., Vieira, J. R., Shah, B., Ramunno, C. F., Dyckow, J., Adler, H., Richter, M., Schermann, G., Giannakouri, E., Schirmer, L., Augustin, H. G., & Ruiz de Almodóvar, C. (2021). Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor–endothelial cell crosstalk. Nature Neuroscience, 1–11. https://doi.org/10.1038/s41593-020-00788-z Cite
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Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic Cancer

Scientists investigated how Hedgehog pathway inhibition reprogramed the pancreatic ductal adenocarcinoma microenvironment.
[Clinical Cancer Research]
Steele, N. G., Biffi, G., Kemp, S. B., Zhang, Y., Drouillard, D., Syu, L.-J., Hao, Y., Oni, T. E., Brosnan, E., Elyada, E., Doshi, A., Hansma, C., Espinoza, C., Abbas, A., The, S., Irizarry-Negron, V. M., Halbrook, C. J., Franks, N., Hoffman, M., … Magliano, M. P. di. (2021). Inhibition of Hedgehog signaling alters fibroblast composition in pancreatic cancer. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-3715 Cite
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