SHH-N Non-Canonically Sustains Androgen Receptor Activity in Androgen-Independent Prostate Cancer Cells

Researchers investigated the role of Hedgehog-GLI signaling in sustaining androgen-independent growth of prostate cancer cells.
[Scientific Reports]
Full Article
Bookmark

No account yet? Register

Share

Medulloblastoma Uses GABA Transaminase to Survive in the Cerebrospinal Fluid Microenvironment and Promote Leptomeningeal Dissemination

Scientists found primary medulloblastoma tumors globally displayed decreased expression of GABA transaminase, the protein responsible for GABA metabolism, compared with normal cerebellum.
[Cell Reports]
Martirosian, V., Deshpande, K., Zhou, H., Shen, K., Smith, K., Northcott, P., Lin, M., Stepanosyan, V., Das, D., Remsik, J., Isakov, D., Boire, A., Feyter, H. D., Hurth, K., Li, S., Wiemels, J., Nakamura, B., Shao, L., Danilov, C., … Neman, J. (2021). Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination. Cell Reports, 35(13). https://doi.org/10.1016/j.celrep.2021.109302 Cite
Abstract
Bookmark

No account yet? Register

Share

Bidirectional Crosstalk between MAOA and AR Promotes Hormone-Dependent and Castration-Resistant Prostate Cancer

The authors reported that monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades monoamine neurotransmitters and dietary amines, reciprocally interacted with androgen receptor (AR) in prostate cancer.
[Cancer Research]
Abstract
Bookmark

No account yet? Register

Share

Establishment of Liver Tumor Cell Lines from Atherogenic and High Fat Diet Fed Hepatitis C Virus Transgenic Mice

Scientists established liver tumor cell lines from hepatitis C virus transgenic mice fed an atherogenic high-fat diet.
[Scientific Reports]
Shirasaki, T., Murai, K., Honda, M., Okada, H., Innami, Y., Yamada, A., Shimakami, T., Kawaguchi, K., Yamashita, T., Sakai, Y., & Kaneko, S. (2021). Establishment of liver tumor cell lines from atherogenic and high fat diet fed hepatitis C virus transgenic mice. Scientific Reports, 11(1), 13021. https://doi.org/10.1038/s41598-021-92128-9 Cite
Full Article
Bookmark

No account yet? Register

Share

A Self-Amplifying Loop of YAP and SHH Drives Formation and Expansion of Heterotopic Ossification

In mouse models of progressive osseous heteroplasia, a disease caused by null mutations in GNAS, researchers found that Gnas−/− mesenchymal cells secreted Sonic hedgehog (SHH), which induced osteoblast differentiation of the surrounding wild-type cells.
[Science Translational Medicine]
Abstract
Bookmark

No account yet? Register

Share

ETV4 Promotes Breast Cancer Cell Stemness by Activating Glycolysis and CXCR4-Mediated Sonic Hedgehog Signaling

Regulation of cancer cell metabolism rewiring and stemness is not completely understood. Scientists reported that ETV4 is a key transcription factor in regulating glycolytic gene expression.
[Cell Death Discovery]
Full Article
Bookmark

No account yet? Register

Share

A Potential Role for Somatostatin Signaling in Regulating Retinal Neurogenesis

By analyzing retinal explants treated with selective ligands that target these receptors, we found that Sstr2-dependent somatostatin signaling induces a modest, dose-dependent inhibition of photoreceptor generation, while correspondingly increasing the relative fraction of primary progenitor cells.
[Scientific Reports]
Weir, K., Kim, D. W., & Blackshaw, S. (2021). A potential role for somatostatin signaling in regulating retinal neurogenesis. Scientific Reports, 11(1), 10962. https://doi.org/10.1038/s41598-021-90554-3 Cite
Full Article
Bookmark

No account yet? Register

Share

NKX6-1 Mediates Cancer Stem-Like Properties and Regulates Sonic Hedgehog Signaling in Leiomyosarcoma

NKX6-1 enhanced in vitro tumor cell aggressiveness via upregulation of cell proliferation and anchorage-independent growth and promoted in vivo tumor growth.
[Journal of Biomedical Science]
Su, P.-H., Huang, R.-L., Lai, H.-C., Chen, L.-Y., Weng, Y.-C., Wang, C.-C., & Wu, C.-C. (2021). NKX6-1 mediates cancer stem-like properties and regulates sonic hedgehog signaling in leiomyosarcoma. Journal of Biomedical Science, 28(1), 32. https://doi.org/10.1186/s12929-021-00726-6 Cite
Full Article
Bookmark

No account yet? Register

Share

Disease-Relevant Single Cell Photonic Signatures Identify S100β Stem Cells and their Myogenic Progeny in Vascular Lesions

Researchers evaluated single cell photonics as a discriminator of cell phenotype in vitro before the presence of vascular stem cells within vascular lesions.
[Stem Cell Reviews and Reports]
Molony, C., King, D., Di Luca, M., Kitching, M., Olayinka, A., Hakimjavadi, R., Julius, L. A. N., Fitzpatrick, E., Gusti, Y., Burtenshaw, D., Healy, K., Finlay, E. K., Kernan, D., Llobera, A., Liu, W., Morrow, D., Redmond, E. M., Ducrée, J., & Cahill, P. A. (2021). Disease-Relevant Single Cell Photonic Signatures Identify S100β Stem Cells and their Myogenic Progeny in Vascular Lesions. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-021-10125-x Cite
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

Share

Acetylation of KLF5 Maintains EMT and Tumorigenicity to Cause Chemoresistant Bone Metastasis in Prostate Cancer

Investigators report that bone-borne TGF-β induced the acetylation of transcription factor KLF5 in prostate cancer bone metastases, and acetylated KLF5 caused osteoclastogenesis and bone metastatic lesions by activating CXCR4, which led to IL-11 secretion, and stimulated SHH/IL-6 paracrine signaling.
[Nature Communications]
Zhang, B., Li, Y., Wu, Q., Xie, L., Barwick, B., Fu, C., Li, X., Wu, D., Xia, S., Chen, J., Qian, W. P., Yang, L., Osunkoya, A. O., Boise, L., Vertino, P. M., Zhao, Y., Li, M., Chen, H.-R., Kowalski, J., … Dong, J.-T. (2021). Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer. Nature Communications, 12(1), 1714. https://doi.org/10.1038/s41467-021-21976-w Cite
Full Article
Bookmark

No account yet? Register

Share

Linking Metabolic Dysfunction with Cardiovascular Diseases: Brn-3b/POU4F2 Transcription Factor in Cardiometabolic Tissues in Health and Disease

Scientists explore the emerging evidence that supports novel and important roles for the POU4F2/Brn-3b transcription factor in controlling cellular genes that regulate cardiometabolic function.
[Cell Death & Disease]
Budhram-Mahadeo, V. S., Solomons, M. R., & Mahadeo-Heads, E. A. O. (2021). Linking metabolic dysfunction with cardiovascular diseases: Brn-3b/POU4F2 transcription factor in cardiometabolic tissues in health and disease. Cell Death & Disease, 12(3), 1–13. https://doi.org/10.1038/s41419-021-03551-9 Cite
Full Article
Bookmark

No account yet? Register

Share
Share