Mice Lacking DYRK2 Exhibit Congenital Malformations with Lung Hypoplasia and Altered Foxf1 Expression Gradient

Researchers showed that Dyrk2-deficient mice display congenital malformations in multiple organs. Transcriptome analysis revealed molecular pathology of Dyrk2-deficient mice, particularly with respect to Foxf1 reduction.
[Communications Biology]
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Integrated Computational Analyses Reveal Novel Insights into the Stromal Microenvironment of SHH-Subtype Medulloblastoma

The authors elucidated the role of the stromal microenvironment in SHH-subgroup medulloblastoma and identified novel treatment possibilities for this challenging disease.
[Scientific Reports]
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Introducing Dorsoventral Patterning in Adult Regenerating Lizard Tails with Gene-Edited Embryonic Neural Stem Cells

Neural-stem cells were isolated from parthenogenetic lizard embryos, rendered unresponsive to Hedgehog signaling via CRISPR/Cas9 gene knockout of smoothened, and implanted back into clonally-identical adults to regulate tail regeneration.
[Nature Communications]
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GLI3 Is Stabilized by SPOP Mutations and Promotes Castration Resistance via Functional Cooperation with Androgen Receptor in Prostate Cancer

The authors showed that GLI3, a key SHH pathway effector, was transcriptionally upregulated during androgen deprivation and posttranslationally stabilized in prostate cancer cells by mutation of speckle-type POZ protein.
[Molecular Cancer Research]
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Lung Cancer Stem Cells and Their Clinical Implications

Mouse models of lung cancer have shown that lung CSCs reside in niches that are essential for the maintenance of stemness, plasticity, enable antitumor immune evasion, and provide metastatic potential.
[Cold Spring Harbor Perspectives in Medicine]
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Stromal Androgen and Hedgehog Signaling Regulates Stem Cell Niches in Pubertal Prostate Development

Researchers demonstrated that selective deletion of stromal androgen-receptor expression in prepubescent Shh responsive Gli1-expressing cells significantly impeded pubertal prostate epithelial growth and development.
[Development]
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A Systematic Summary of Survival and Death Signalling during the Life of Hair Follicle Stem Cells

Scientists highlight the potential mechanisms underlying the therapeutic targets involved in pathways associated with the treatment of hair loss and other disorders of skin and hair, including alopecia, skin cancer, skin inflammation, and skin wound healing.
[Stem Cell Research & Therapy]
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SHH-N Non-Canonically Sustains Androgen Receptor Activity in Androgen-Independent Prostate Cancer Cells

Researchers investigated the role of Hedgehog-GLI signaling in sustaining androgen-independent growth of prostate cancer cells.
[Scientific Reports]
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Medulloblastoma Uses GABA Transaminase to Survive in the Cerebrospinal Fluid Microenvironment and Promote Leptomeningeal Dissemination

Scientists found primary medulloblastoma tumors globally displayed decreased expression of GABA transaminase, the protein responsible for GABA metabolism, compared with normal cerebellum.
[Cell Reports]
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Bidirectional Crosstalk between MAOA and AR Promotes Hormone-Dependent and Castration-Resistant Prostate Cancer

The authors reported that monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades monoamine neurotransmitters and dietary amines, reciprocally interacted with androgen receptor (AR) in prostate cancer.
[Cancer Research]
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Establishment of Liver Tumor Cell Lines from Atherogenic and High Fat Diet Fed Hepatitis C Virus Transgenic Mice

Scientists established liver tumor cell lines from hepatitis C virus transgenic mice fed an atherogenic high-fat diet.
[Scientific Reports]
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