ActivinA Activates Notch1-Shh Signaling to Regulate Proliferation in C2C12 Skeletal Muscle Cells

Scientists determined the physiological functions of Activin A, Notch and Sonic Hedgehog signaling in the proliferation of mouse C2C12 myoblasts and to explore their interactions.
[Molecular and Cellular Endocrinology]
Ma, L., Li, C., Lian, S., Xu, B., Yuan, J., Lu, J., Yang, H., Guo, J., & Ji, H. (2021). ActivinA activates Notch1-Shh signaling to regulate proliferation in C2C12 skeletal muscle cells. Molecular and Cellular Endocrinology, 519, 111055. https://doi.org/10.1016/j.mce.2020.111055 Cite
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Epithelial WNT2b and Desert Hedgehog Are Necessary for Human Colonoid Regeneration after Bacterial Cytotoxin Injury

Using the enterohemorrhagic E. coli secreted cytotoxin, EspP to induce injury to human colonoids, researchers evaluated a simplified, epithelial regeneration model that lacks mesenchymal Wnts. They demonstrated that epithelial-produced WNT2B was upregulated following injury and essential for regeneration.
[iScience]
Epithelial WNT2B and Desert Hedgehog are necessary for human colonoid regeneration after bacterial cytotoxin injury: iScience. (n.d.). Retrieved September 29, 2020, from https://www.cell.com/iscience/fulltext/S2589-0042(20)30810-5 Cite
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Berberine Inhibits Colorectal Tumor Growth by Suppressing SHH Secretion

Berberine promotes the degradation of SHH mRNA in colorectal cancer cells, interrupting the paracrine Hedgehog signaling pathway activity thus suppresses the colorectal cancer growth.
[Acta Pharmacologica Sinica]
Berberine inhibits colorectal tumor growth by suppressing SHH secretion | Acta Pharmacologica Sinica. (n.d.). Retrieved September 21, 2020, from https://www.nature.com/articles/s41401-020-00514-2 Cite
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Engineered Biomimetic Nanoparticle for Dual Targeting of the Cancer Stem-Like Cell Population in Sonic Hedgehog Medulloblastoma

Investigators demonstrated the dual-targeted delivery and enhanced therapeutic effect of eHNP-A1-CD15-LDE225 via scavenger receptor class B type 1and CD15 on brain sonic hedgehog subtype of medulloblastoma cells in vitro, ex vivo, and in vivo.
[Proceedings of the National Academy of Sciences of the United States of America]
Kim, J., Dey, A., Malhotra, A., Liu, J., Ahn, S. I., Sei, Y. J., Kenney, A. M., MacDonald, T. J., & Kim, Y. (2020). Engineered biomimetic nanoparticle for dual targeting of the cancer stem-like cell population in sonic hedgehog medulloblastoma. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1911229117 Cite
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Overactivated Sonic Hedgehog Signaling Aggravates Intrauterine Adhesion via Inhibiting Autophagy in Endometrial Stromal Cells

Scientists report that impaired autophagy participated in sonic hedgehog signaling pathway-induced endometrial fibrosis.
[Cell Death & Disease]
Wei, C., Pan, Y., Zhang, Y., Dai, Y., Jiang, L., Shi, L., Yang, W., Xu, S., Zhang, Y., Xu, W., Zhang, Y., Lin, X., & Zhang, S. (2020). Overactivated sonic hedgehog signaling aggravates intrauterine adhesion via inhibiting autophagy in endometrial stromal cells. Cell Death & Disease, 11(9), 1–15. https://doi.org/10.1038/s41419-020-02956-2 Cite
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Wnt Activation as a Therapeutic Strategy in Medulloblastoma

By using primary patient-derived medulloblastoma (MB) brain tumor-initiating cell lines, investigators characterized differences in the tumor-initiating capacity of Wnt, group three, and group four MB.
[Nature Communications]
Manoranjan, B., Venugopal, C., Bakhshinyan, D., Adile, A. A., Richards, L., Kameda-Smith, M. M., Whitley, O., Dvorkin-Gheva, A., Subapanditha, M., Savage, N., Tatari, N., McKenna, D., Bassey-Archibong, B., Winegarden, N., Hallett, R., Provias, J. P., Yarascavitch, B., Ajani, O., Fleming, A., … Singh, S. K. (2020). Wnt activation as a therapeutic strategy in medulloblastoma. Nature Communications, 11(1), 4323. https://doi.org/10.1038/s41467-020-17953-4 Cite
AbstractPress Release
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Bidirectional Wnt Signaling between Endoderm and Mesoderm Confers Tracheal Identity in Mouse and Human Cells

Investigators showed that canonical Wnt signaling in mesoderm was critical to confer trachea mesenchymal identity in human and mouse.
[Nature Communications]
Kishimoto, K., Furukawa, K. T., Luz-Madrigal, A., Yamaoka, A., Matsuoka, C., Habu, M., Alev, C., Zorn, A. M., & Morimoto, M. (2020). Bidirectional Wnt signaling between endoderm and mesoderm confers tracheal identity in mouse and human cells. Nature Communications, 11(1), 4159. https://doi.org/10.1038/s41467-020-17969-w Cite
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High-Throughput 3D Screening for Differentiation of hPSC-Derived Cell Therapy Candidates

Researchers demonstrated a high-throughput 3D culture platform used to systematically screen 1200 culture conditions with varying doses, durations, dynamics, and combinations of signaling cues to derive oligodendrocyte progenitor cells and midbrain dopaminergic neurons from human PSCs.
[Science Advances]
Muckom, R., Bao, X., Tran, E., Chen, E., Murugappan, A., Dordick, J. S., Clark, D. S., & Schaffer, D. V. (2020). High-throughput 3D screening for differentiation of hPSC-derived cell therapy candidates. Science Advances, 6(32), eaaz1457. https://doi.org/10.1126/sciadv.aaz1457 Cite
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Broccoli Extract Increases Drug-Mediated Cytotoxicity towards Cancer Stem Cells of Head and Neck Squamous Cell Carcinoma

Researchers investigated whether sulforaphane could enhance the chemotherapeutic effects of cisplatin and 5-fluorouracil against head and neck squamous cell carcinomas–cancer stem cells, and its mechanisms of action.
[British Journal of Cancer]
Elkashty, O. A., & Tran, S. D. (2020). Broccoli extract increases drug-mediated cytotoxicity towards cancer stem cells of head and neck squamous cell carcinoma. British Journal of Cancer, 1–9. https://doi.org/10.1038/s41416-020-1025-1 Cite
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Acute Alcohol Intoxication Impairs SHH‐Gli1 Signaling and Activation of Primitive Hematopoietic Precursor Cells in the Early Stage of Host Response to Bacteremia

Investigators determined the effect of alcohol exposure on sonic hedgehog signaling in the regulation of hematopoietic stem cell activation during bacteremia.
[Alcoholism-Clinical and Experimental Research]
Shi, X., Simms, K. J., & Zhang, P. (n.d.). Acute Alcohol Intoxication Impairs SHH-Gli1 Signaling and Activation of Primitive Hematopoietic Precursor Cells in the Early Stage of Host Response to Bacteremia. Alcoholism: Clinical and Experimental Research, n/a(n/a). https://doi.org/10.1111/acer.14429 Cite
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Modeling SHH-Driven Medulloblastoma with Patient iPS Cell-Derived Neural Stem Cells

Investigators describe a medulloblastoma model using induced pluripotent stem cell-derived human neuroepithelial stem cells generated from a Gorlin syndrome patient carrying a germline mutation in the sonic hedgehog receptor PTCH1.
[Proceedings of the National Academy of Sciences of the United States of America]
Susanto, E., Navarro, A. M., Zhou, L., Sundström, A., Bree, N. van, Stantic, M., Moslem, M., Tailor, J., Rietdijk, J., Zubillaga, V., Hübner, J.-M., Weishaupt, H., Wolfsberger, J., Alafuzoff, I., Nordgren, A., Magnaldo, T., Siesjö, P., Johnsen, J. I., Kool, M., … Wilhelm, M. (2020). Modeling SHH-driven medulloblastoma with patient iPS cell-derived neural stem cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1920521117 Cite
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