3D Spheroid Models of Pediatric SHH Medulloblastoma Mimic Tumor Biology, Drug Response and Metastatic Dissemination

When grown under the same stem cell enriching conditions, SHH subgroup medulloblastoma cell lines established tight, highly reproducible 3D spheroids that could be maintained for weeks in culture and formed pathophysiological oxygen gradients.
[Scientific Reports]
Roper, S. J., Linke, F., Scotting, P. J., & Coyle, B. (2021). 3D spheroid models of paediatric SHH medulloblastoma mimic tumour biology, drug response and metastatic dissemination. Scientific Reports, 11(1), 4259. https://doi.org/10.1038/s41598-021-83809-6 Cite
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Upregulation of LINC01426 Promotes the Progression and Stemness in Lung Adenocarcinoma by Enhancing the Level of SHH Protein to Activate the Hedgehog Pathway

Functionally, silencing of LINC01426 obviously suppressed the proliferation, migration, epithelial–mesenchymal transition, and stemness of lung adenocarcinoma cells.
[Cell Death & Disease]
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Targeting the Sonic Hedgehog Pathway to Suppress the Expression of the Cancer Stem Cell (CSC)—Related Transcription Factors and CSC-Driven Thyroid Tumor Growth

Scientists report that inhibition of the sonic hedgehog pathway by Gli1 siRNA or by cyclopamine and GANT61 reduced BMI1 and SOX2 expression in SW1736 and KAT-18 cells, two anaplastic thyroid cancer cell lines.
[Cancers]
Lu, Y., Zhu, Y., Deng, S., Chen, Y., Li, W., Sun, J., & Xu, X. (2021). Targeting the Sonic Hedgehog Pathway to Suppress the Expression of the Cancer Stem Cell (CSC)—Related Transcription Factors and CSC-Driven Thyroid Tumor Growth. Cancers, 13(3), 418. https://doi.org/10.3390/cancers13030418 Cite
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Optogenetic Manipulation of Cellular Communication Using Engineered Myosin Motors

Researchers presented a versatile optogenetic toolbox of artificial multi-headed myosin motors that could move bidirectionally within long cellular extensions and allowed for the selective transport of GFP-tagged cargo with light.
[Nature Cell Biology]
Zhang, Z., Denans, N., Liu, Y., Zhulyn, O., Rosenblatt, H. D., Wernig, M., & Barna, M. (2021). Optogenetic manipulation of cellular communication using engineered myosin motors. Nature Cell Biology, 1–11. https://doi.org/10.1038/s41556-020-00625-2 Cite
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Oligodendrocyte Precursor Cell Specification Is Regulated by Bidirectional Neural Progenitor–Endothelial Cell Crosstalk

Researchers identified bidirectional crosstalk between the neural and the vascular compartment of the developing CNS required for oligodendrocyte precursor cell specification.
[Nature Neuroscience]
Paredes, I., Vieira, J. R., Shah, B., Ramunno, C. F., Dyckow, J., Adler, H., Richter, M., Schermann, G., Giannakouri, E., Schirmer, L., Augustin, H. G., & Ruiz de Almodóvar, C. (2021). Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor–endothelial cell crosstalk. Nature Neuroscience, 1–11. https://doi.org/10.1038/s41593-020-00788-z Cite
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Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic Cancer

Scientists investigated how Hedgehog pathway inhibition reprogramed the pancreatic ductal adenocarcinoma microenvironment.
[Clinical Cancer Research]
Steele, N. G., Biffi, G., Kemp, S. B., Zhang, Y., Drouillard, D., Syu, L.-J., Hao, Y., Oni, T. E., Brosnan, E., Elyada, E., Doshi, A., Hansma, C., Espinoza, C., Abbas, A., The, S., Irizarry-Negron, V. M., Halbrook, C. J., Franks, N., Hoffman, M., … Magliano, M. P. di. (2021). Inhibition of Hedgehog signaling alters fibroblast composition in pancreatic cancer. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-3715 Cite
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Alveolar Epithelial Cell‐Derived Sonic Hedgehog Promotes Pulmonary Fibrosis through OPN‐Dependent Alternative Macrophage Activation

Scientists investigated the interaction between macrophages and fibrosis‐associated alveolar epithelial cells using a bleomycin‐induced mouse pulmonary fibrosis model and a co‐culture system.
[FEBS Journal]
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Downregulation of miR-506-3p Facilitates EGFR-TKI Resistance through Induction of Sonic Hedgehog Signaling in Non-Small-Cell Lung Cancer Cell Lines

Scientists report that miR-506-3p expression was markedly reduced in erlotinib-resistant (ER) cells. They identified Sonic Hedgehog as a novel target of miR-506-3p, aberrantly activated in ER cells.
[International Journal of Molecular Sciences]
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Antiapoptotic Bcl-2 Family Proteins BCL-XL and MCL-1 Integrate Neural Progenitor Survival and Proliferation during Postnatal Cerebellar Neurogenesis

To define the mechanisms linking proliferation and apoptotic threshold, researchers examined the effect of conditionally deleting Bcl2l1, the gene that codes the antiapoptotic protein BCL-xL, in cerebellar granule neuron progenitors, and of co-deleting Bcl2l1 homologs, antiapoptotic Mcl-1, or pro-apoptotic Bax.
[Cell Death & Differentiation]
Veleta, K. A., Cleveland, A. H., Babcock, B. R., He, Y.-W., Hwang, D., Sokolsky-Papkov, M., & Gershon, T. R. (2020). Antiapoptotic Bcl-2 family proteins BCL-xL and MCL-1 integrate neural progenitor survival and proliferation during postnatal cerebellar neurogenesis. Cell Death & Differentiation, 1–14. https://doi.org/10.1038/s41418-020-00687-7 Cite
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GATA6 Regulates Aging of Human Mesenchymal Stem/Stromal Cells

Investigators reprogrammed human synovial fluid‐derived MSCs into induced pluripotent stem cells (iPSCs) using six reprogramming factors and reverted the iPSCs back to MSCs, as an approach to cell rejuvenation.
[Stem Cells]
Jiao, H., Walczak, B. E., Lee, M.-S., Lemieux, M. E., & Li, W.-J. (n.d.). GATA6 regulates aging of human mesenchymal stem/stromal cells. STEM CELLS, n/a(n/a). https://doi.org/https://doi.org/10.1002/stem.3297 Cite
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Thyroid Hormone-Induced Expression of Foxl1 in Subepithelial Fibroblasts Correlates with Adult Stem Cell Development during Xenopus Intestinal Remodeling

Foxl1 expression was transiently upregulated only in connective tissue cells during the early period of metamorphic climax and was the highest just beneath the proliferating stem/progenitor cells.
[Scientific Reports]
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