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SHH

A Noncanonical Hedgehog Signaling Exerts a Tumor-Promoting Effect on Pancreatic Cancer Cells via Induction of Osteopontin Expression

[Cancer Biotherapy and Radiopharmaceuticals] Researchers analyzed the correlation between Sonic Hedgehog or Gli1 and osteopontin expression in human pancreatic ductal adenocarcinoma. They also evaluated the proliferation, apoptosis, migration, and invasion of Gli1-knockdown BxPC-3 cells.

Human Stem Cell-Derived Thymic Epithelial Cells Enhance Human T Cell Development in a Xenogeneic Thymus

[Journal of Allergy and Clinical Immunology] Scientists generated human thymic epithelial progenitors from human embryonic stem cells and to assess their thymopoietic function in vivo.

Mice Lacking DYRK2 Exhibit Congenital Malformations with Lung Hypoplasia and Altered Foxf1 Expression Gradient

[Communications Biology] Researchers showed that Dyrk2-deficient mice display congenital malformations in multiple organs. Transcriptome analysis revealed molecular pathology of Dyrk2-deficient mice, particularly with respect to Foxf1 reduction.

Integrated Computational Analyses Reveal Novel Insights into the Stromal Microenvironment of SHH-Subtype Medulloblastoma

[Scientific Reports] The authors elucidated the role of the stromal microenvironment in SHH-subgroup medulloblastoma and identified novel treatment possibilities for this challenging disease.

Introducing Dorsoventral Patterning in Adult Regenerating Lizard Tails with Gene-Edited Embryonic Neural Stem Cells

[Nature Communications] Neural-stem cells were isolated from parthenogenetic lizard embryos, rendered unresponsive to Hedgehog signaling via CRISPR/Cas9 gene knockout of smoothened, and implanted back into clonally-identical adults to regulate tail regeneration.

GLI3 Is Stabilized by SPOP Mutations and Promotes Castration Resistance via Functional Cooperation with Androgen Receptor in Prostate Cancer

[Molecular Cancer Research] The authors showed that GLI3, a key SHH pathway effector, was transcriptionally upregulated during androgen deprivation and posttranslationally stabilized in prostate cancer cells by mutation of speckle-type POZ protein.

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